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42 results for "Compounds for Induced Pluripotent Stem Cells Small Molecules and Peptides" in Products

Compounds for Induced Pluripotent Stem Cells: Small Molecules and Peptides

Reprogramming of cells refers to the regression of a specialized cell to a simpler state, resulting in cells with stem-like properties, or the direct transformation of one specialized cell type into another, which is also known as transdifferentiation. The process of cells regressing to a stem cell-like state occurs naturally, mostly for repair and regeneration in aged or damaged tissues, being also known as dedifferentiation. Reprogramming can be artificially induced using a combination of ...

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Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Purity: ≥99% (HPLC)
dopaminergic neurons derived from hiPSCs using SB 431542
(2)

SB 431542 synthesized to cGMP guidelines

Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Purity: ≥99%
SB 431542 synthesized to cGMP guidelines

Highly selective GSK-3 inhibitor; acts as Wnt activator

Alternate Names: CHIR99021,CT99021
Chemical Name: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Purity: ≥98%
Cardiomyocyte derived from human induced pluripotent stem cells (hiPSCs) using CHIR 99021.
(2)

CHIR 99021 synthesized to cGMP guidelines

Chemical Name: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Purity: ≥99%
CHIR 99021 synthesized to cGMP guidelines
(2)

Selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Purity: ≥98% (HPLC)
Adult Stem Cell-derived Liver Organoids
(6)

EZH2 histone methyltransferase inhibitor

Alternate Names: DZNep,NSC 617989,HY-12186
Chemical Name: (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride
Purity: ≥98% (HPLC)
EZH2 histone methyltransferase inhibitor

Adenylyl cyclase activator

Alternate Names: Coleonol,Colforsin
Chemical Name: (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
Purity: ≥98% (HPLC)
Adult Stem Cell-derived Liver Organoids
(2)

Potent tankyrase inhibitor

Alternate Names: XAV939 Wnt Signaling Inhibitor
Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Purity: ≥98% (HPLC)
Potent tankyrase inhibitor

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Chemical Name: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
Purity: ≥99% (HPLC)
Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Potent inhibitor of Wnt/β-catenin signaling

Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Purity: ≥98% (HPLC)
Potent inhibitor of Wnt/β-catenin signaling

Induces definitive endoderm formation in mouse and human ESCs

Chemical Name: 1-[2-[(2-Carboxyphenyl)methylene]hydrazide]heptanoic acid
Purity: ≥98% (HPLC)
Induces definitive endoderm formation in mouse and human ESCs

Enhances the generation of iPSCs; increases reprogramming efficiency

Alternate Names: L-Ascorbate,Vitamin C
Chemical Name: 3-Oxo-L-gulofuranolactone
Purity: ≥99% (HPLC)
Enhances the generation of iPSCs; increases reprogramming efficiency

Wnt/β-catenin signaling inhibitor; axin stabilizer

Chemical Name: rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
Purity: ≥98% (HPLC)
Wnt/β-catenin signaling inhibitor; axin stabilizer

Potent inhibitor of MEK1/2

Alternate Names: PD325901
Chemical Name: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
Purity: ≥99% (HPLC)
Potent inhibitor of MEK1/2

Potent and selective inhibitor of TGF-βRI

Alternate Names: E-616452,SJN 2511,ALK5 Inhibitor II
Chemical Name: 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Purity: ≥99% (HPLC)
Potent and selective inhibitor of TGF-βRI

Histone deacetylase inhibitor

Alternate Names: VPA,Sodium Valproate
Chemical Name: Sodium 2-propylpentanoate
Histone deacetylase inhibitor

GLP and G9a inhibitor

Chemical Name: 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride
Purity: ≥98% (HPLC)
GLP and G9a inhibitor

ROCK inhibitor; improves the efficiency of fibroblast reprogramming and induction of iPSCs

Chemical Name: N-Benzyl-[2-(pyrimidin-4-yl)amino]thiazole-4-carboxamide
Purity: ≥98% (HPLC)
ROCK inhibitor ; improves the efficiency of fibroblast reprogramming and induction of iPSCs

PORCN inhibitor; inhibits Wnt processing and secretion

Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Purity: ≥98% (HPLC)
iPSC-derived heart organoids differentiated with IWP 2 and CHIR 99021
(2)

L-Ascorbic acid synthesized to Ancillary Material Grade

Chemical Name: 3-Oxo-L-gulofuranolactone
Purity: ≥99%
L-Ascorbic acid synthesized to Ancillary Material Grade

XAV 939 synthesized to cGMP guidelines

Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Purity: ≥99%
XAV 939 synthesized to cGMP guidelines

Inhibitor of Hedgehog (Hh) signaling

Chemical Name: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol
Purity: ≥97% (HPLC)
Inhibitor of Hedgehog (Hh) signaling

Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

Chemical Name: N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide
Purity: ≥98% (HPLC)
Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

Irreversible inhibitor of LSD1; also inhibits MAO

Alternate Names: 2-PCPA
Chemical Name: (±)-trans-2-Phenylcyclopropylamine hydrochloride
Purity: ≥98% (HPLC)
Irreversible inhibitor of LSD1; also inhibits MAO

Histone deacetylase inhibitor

Chemical Name: Butanoic acid sodium salt
Histone deacetylase inhibitor
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