O4I2
Tocris Bioscience, part of Bio-Techne | Catalog # 5664
Oct3/4 inducer; induces expression of pluripotent-associated genes
Key Product Details
Description
Oct3/4 inducer; induces expression of pluripotent-associated genes
Product Description
O4I2 is an Oct3/4 inducer; promotes Oct3/4 expression and stabilizes the Oct3/4 protein in HEK293 cells. Induces expression of pluripotent-associated genes Lin28, Sox2 and Nanog, and suppresses Rex1. Induces 15-fold increase in Oct3/4 expression in human primary fibroblasts.Product Specifications
Molecular Weight
282.75
Formula
C12H11ClN2O2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
Ethyl 2-[(4-chlorophenyl)amino]-4-thiazolecarboxylate
CAS Number
165682-93-9
PubChem ID
53428670
InChI Key
ULUBAPWNHROTEU-UHFFFAOYSA-N
SMILES
ClC(C=C2)=CC=C2NC1=NC(C(OCC)=O)=CS1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.27 | 100 | |
| Ethanol | 14.14 | 50 |
Preparing Stock Solutions
for O4I2
The following data is based on the product molecular weight 282.75
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.54 mL | 17.68 mL | 35.37 mL |
| 5 mM | 0.71 mL | 3.54 mL | 7.07 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cheng Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and derivatives are potent inducers of Oct3/4. J.Med.Chem. 2015 PMID: 26143659
Product Specific Notices for O4I2
For research use only
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