(±)-Bay K 8644

Name: (±)-Bay K 8644
Brand: Tocris Bioscience
SKU: 1544
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1544

(1)

Citations (89)

COA / SDS

CaV1.x activator

Key Product Details

Description:	Ca_V1.x activator
Chemical Name:	1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	356.3

View Full Technical Details for (±)-Bay K 8644

Technical Data
Citations / Reviews (1)

Biological Activity for (±)-Bay K 8644

(±)-Bay K 8644 is a L-type Ca²⁺ channel activator (EC₅₀ = 17.3 nM). Has positive inotropic, vasoconstrictive and behavioral effects in vivo. In combination with BIX-01294 (Cat. No. 3364), helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). Inhibits autophagy.

(S)-(-)-Enantiomer and (R)-(+)-Enantiomer also available.

Technical Data for (±)-Bay K 8644

M. Wt	356.3
Formula	C₁₆H₁₅F₃N₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	71145-03-4
PubChem ID	2303
InChi Key	ZFLWDHHVRRZMEI-UHFFFAOYSA-N
Smiles	COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1C(F)(F)F)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (±)-Bay K 8644

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	35.63	100
	DMSO	35.63	100

Preparing Stock Solutions for (±)-Bay K 8644

The following data is based on the product molecular weight 356.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.81 mL	14.03 mL	28.07 mL
5 mM	0.56 mL	2.81 mL	5.61 mL
10 mM	0.28 mL	1.40 mL	2.81 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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Reconstitution Calculator

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References for (±)-Bay K 8644

References are publications that support the biological activity of the product.

Sarkar Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ. 2009 PMID: 18636076
Greenberg Calcium channel 'agonist' BAY K 8644 inhibits calcium antagonist binding to brain and PC12 cell membranes. Brain Res. 1984 PMID: 6204725
Shi Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 2008 PMID: 18983970
Bourson Central and peripheral effects of the dihydropyridine calcium channel activator BAY K 8644 in the rat. Eur.J.Pharmacol. 1989 PMID: 2469593