12 results for "Akt1 Small Molecules and Peptides" in Products
Akt1: Small Molecules and Peptides
Akt1, Akt2, and Akt3 make up a family of serine/threonine kinases, often activated downstream of growth factor receptors and PI 3-Kinase. Each Akt family member contains an N-terminal pleckstrin homology (PH) domain, a central kinase domain, and a C-terminal regulatory domain. They have putative roles in cell proliferation and survival, and Akt perturbations are thought to play an important role in tumorigenesis.
Potent and selective allosteric Akt1, Akt2 and Akt3 inhibitor
| Chemical Name: | 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective dual Akt1 and 2 inhibitor
| Alternate Names: | Akt Inhibitor VIII |
| Chemical Name: | 1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
| Alternate Names: | Triciribine,NSC 154020,TCN |
| Chemical Name: | 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine |
| Purity: | ≥98% (HPLC) |
PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro
| Chemical Name: | 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one |
| Purity: | ≥98% (HPLC) |
Potent MSK1 inhibitor; also inhibits other AGC group kinases
| Chemical Name: | 2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-4-piperidinyl-1H-imidazo[4,5-c]pyridine-7-methanamine dihydrochloride |
| Purity: | ≥98% (HPLC) |
Potent pan-Akt and PKA inhibitor
| Chemical Name: | 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective Akt/PKB inhibitor
| Alternate Names: | Akt Inhibitor X |
| Chemical Name: | 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride |
| Purity: | ≥98% (HPLC) |
Akt activator
| Chemical Name: | 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester |
Potent pan-AKT inhibitor
| Alternate Names: | Capivasertib |
| Chemical Name: | 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide |
| Purity: | ≥98% (HPLC) |
Akt kinase inhibitor. Antitumor
| Chemical Name: | 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol |
| Purity: | ≥98% (HPLC) |
PKB/Akt inhibitor; also modulates Kv2.1 current
| Alternate Names: | KRX-0401 |
| Chemical Name: | Octadecyl-(1,1-dimethyl-4-piperidylio) phosphate |
| Purity: | ≥98% (HPLC) |
Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates
| Chemical Name: | 6-(2-Benzothiazolyl)-1-ethyl-2-[(1E)-2-(methylphenylamino)ethenyl]-3-phenyl-1H-benzimidazolium iodide |
| Purity: | ≥98% (HPLC) |
