Urolithin A
Tocris Bioscience, part of Bio-Techne | Catalog # 6762
PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro
Key Product Details
Description
PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro
Product Description
Urolithin A is a PI 3-K/Akt/mTOR signaling pathway inhibitor; blocks phosphorylation of Akt and p70S6K in pancreatic ductal adenocarcinoma (PDAC). Inhibits proliferation and migration and promotes apoptosis of PDAC cell lines in vitro (IC50 values are 10.23 - 62.28 μM). Suppresses tumor growth and improves survival in mice bearing pancreatic tumor xenografts. Also blocks amyloid-β fibrillation in vitro.Product Specifications
Molecular Weight
228.20
Formula
C13H8O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one
CAS Number
1143-70-0
PubChem ID
5488186
InChI Key
RIUPLDUFZCXCHM-UHFFFAOYSA-N
SMILES
OC1=CC=C2C(OC(C3=CC(O)=CC=C23)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.82 | 100 |
Preparing Stock Solutions
for Urolithin A
The following data is based on the product molecular weight 228.20
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.38 mL | 21.91 mL | 43.82 mL |
| 5 mM | 0.88 mL | 4.38 mL | 8.76 mL |
| 10 mM | 0.44 mL | 2.19 mL | 4.38 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.88 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yuan Pomegranate's neuroprotective effects against Alzheimer's disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites. ACS Chem.Neurosci. 2016 PMID: 26559394
- Totiger Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer. Mol.Cancer Ther. 2019 PMID: 30404927
Product Specific Notices for Urolithin A
For research use only
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