GSK 690693

Name: GSK 690693
Brand: Tocris Bioscience
SKU: 4144
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4144

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Citations (26)

COA / SDS

Akt kinase inhibitor. Antitumor

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Product Description
Licensing Information
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Akt kinase inhibitor. Antitumor

View all Akt (Protein Kinase B) Inhibitors »

Product Description

GSK 690693 is an ATP-competitive pan-Akt kinase inhibitor (IC₅₀ values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC₅₀ < 100 nM). Displays antiproliferative and apoptotic effects in tumor cell lines.

Licensing Information

Sold for research purposes only under agreement from GlaxoSmithKline

Product Specifications

Molecular Weight

425.48

Formula

C₂₁H₂₇N₇O₃

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol

CAS Number

937174-76-0

PubChem ID

90488916

InChI Key

WONPMIMNXYCXKK-AWEZNQCLSA-N

SMILES

NC1=NON=C1C(N3CC)=NC2=C3C(CO[C@@H]4CNCCC4)=CN=C2C#CC(C)(C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.27	50

Preparing Stock Solutions for GSK 690693

The following data is based on the product molecular weight 425.48

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.70 mL	23.50 mL	47.01 mL
2.5 mM	0.94 mL	4.70 mL	9.40 mL
5 mM	0.47 mL	2.35 mL	4.70 mL
25 mM	0.09 mL	0.47 mL	0.94 mL

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Background References

References are publications that support the biological activity of the product.

Rhodes Characterization of an Akt inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res. 2008 PMID: 18381444
Heerding Identification of 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{(3S)-3-piperidinylmethoxyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J.Med.Chem. 2008 PMID: 18800763