API-2
Tocris Bioscience, part of Bio-Techne | Catalog # 2151
Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
Key Product Details
Description
Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
Alternative Names
Triciribine,NSC 154020,TCN
Product Description
API-2 is a selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3β and AFX. Induces apoptosis and growth arrest in vitro, preferentially in human cancer cells with elevated levels of Akt. Potently and selectively inhibits growth of Akt-overexpressing tumors in mice. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.Product Specifications
Molecular Weight
320.31
Formula
C13H16N6O4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
CAS Number
35943-35-2
PubChem ID
65399
InChI Key
HOGVTUZUJGHKPL-HTVVRFAVSA-N
SMILES
O[C@@H]1[C@@H](CO)O[C@@H](N2C3=C(C4=NC=N3)C(C(N)=NN4C)=C2)[C@@H]1O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 32.03 | 100 | |
| DMSO | 32.03 | 100 |
Preparing Stock Solutions
for API-2
The following data is based on the product molecular weight 320.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.12 mL | 15.61 mL | 31.22 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.24 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.12 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ptak Phosphorylation of triciribine is necessary for activity against HIV type 1. AIDS Res.Hum.Retroviruses. 1998 PMID: 9788672
- Yang Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumour activity in cancer cells overexpressing Akt. Cancer Res. 2004 PMID: 15231645
- Wotring Dual mechanisms of inhibition of DNA synthesis by triciribine. Cancer Res. 1990 PMID: 2379153
Product Specific Notices for API-2
For research use only
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