10-DEBC hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2558
Selective Akt/PKB inhibitor
Key Product Details
Description
Selective Akt/PKB inhibitor
Alternative Names
Akt Inhibitor X
Product Description
10-DEBC hydrochloride is a selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6 μM) and induces apoptosis in rhabdomyosarcoma cells.Product Specifications
Molecular Weight
381.34
Formula
C20H25N2OCl.HCl
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride
CAS Number
925681-41-0
PubChem ID
16760284
InChI Key
SVKSJUIYYCQZEC-UHFFFAOYSA-N
SMILES
Cl.CCN(CC)CCCCN1C2=CC=CC=C2OC2=C1C=C(Cl)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 38.13 | 100 | |
| DMSO | 38.13 | 100 |
Preparing Stock Solutions
for 10-DEBC hydrochloride
The following data is based on the product molecular weight 381.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.62 mL | 13.11 mL | 26.22 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.24 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.62 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Thimmaiah Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling. J.Biol.Chem.
- Thimmaiah Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells. J.Med.Chem. 1992 PMID: 1527786
Product Specific Notices for 10-DEBC hydrochloride
For research use only
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