AZD 5363
Tocris Bioscience, part of Bio-Techne | Catalog # 6978
Potent pan-AKT inhibitor
Key Product Details
Description
Potent pan-AKT inhibitor
Alternative Names
Capivasertib
Product Description
AZD 5363 is a potent pan-AKT inhibitor (IC50 values are 3, 7 and 7 nM for AKt 1, 2 and 3, respectively). Also inhibits P70S6K, PKA, ROCK2 and ROCK1 (IC50 values are 6, 7, 60 and 470 nM, respectively). Inhibits growth of tumor cell lines in vitro, particularly breast, endometrial, gastric, hematologic and prostate cancers. Inhibits growth of human tumor xenografts in mice. Enhances in vivo antitumor effects of Docetaxel (Cat. No. 4056) and Lapatinib (Cat. No. 6811). Orally bioavailable.Product Specifications
Molecular Weight
428.92
Formula
C21H25ClN6O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide
CAS Number
1143532-39-1
PubChem ID
25227436
InChI Key
JDUBGYFRJFOXQC-KRWDZBQOSA-N
SMILES
NC1(CCN(CC1)C1=C2C=CNC2=NC=N1)C(=O)N[C@@H](CCO)C1=CC=C(Cl)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.89 | 100 |
Preparing Stock Solutions
for AZD 5363
The following data is based on the product molecular weight 428.92
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.66 mL | 23.31 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Davies Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol.Cancer Ther. 2012 PMID: 22294718
Product Specific Notices for AZD 5363
For research use only
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