Akt: Small Molecules and Peptides
Akt1, Akt2, and Akt3 make up a family of serine/threonine kinases, often activated downstream of growth factor receptors and PI 3-Kinase. Each Akt family member contains an N-terminal pleckstrin homology (PH) domain, a central kinase domain, and a C-terminal regulatory domain. They have putative roles in cell proliferation and survival, and Akt perturbations are thought to play an important role in tumorigenesis.
11 results for "Akt Small Molecules and Peptides" in Products
11 results for "Akt Small Molecules and Peptides" in Products
Akt: Small Molecules and Peptides
Akt1, Akt2, and Akt3 make up a family of serine/threonine kinases, often activated downstream of growth factor receptors and PI 3-Kinase. Each Akt family member contains an N-terminal pleckstrin homology (PH) domain, a central kinase domain, and a C-terminal regulatory domain. They have putative roles in cell proliferation and survival, and Akt perturbations are thought to play an important role in tumorigenesis.
Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates
| Chemical Name: | 6-(2-Benzothiazolyl)-1-ethyl-2-[(1E)-2-(methylphenylamino)ethenyl]-3-phenyl-1H-benzimidazolium iodide |
| Purity: | ≥98% (HPLC) |
Akt activator
| Chemical Name: | 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester |
PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro
| Chemical Name: | 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
| Alternate Names: | Triciribine,NSC 154020,TCN |
| Chemical Name: | 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine |
| Purity: | ≥98% (HPLC) |
Selective Akt/PKB inhibitor
| Alternate Names: | Akt Inhibitor X |
| Chemical Name: | 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective dual Akt1 and 2 inhibitor
| Alternate Names: | Akt Inhibitor VIII |
| Chemical Name: | 1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one |
| Purity: | ≥98% (HPLC) |
PKB/Akt inhibitor; also modulates Kv2.1 current
| Alternate Names: | KRX-0401 |
| Chemical Name: | Octadecyl-(1,1-dimethyl-4-piperidylio) phosphate |
| Purity: | ≥98% (HPLC) |
Akt kinase inhibitor. Antitumor
| Chemical Name: | 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol |
| Purity: | ≥98% (HPLC) |
Potent pan-Akt and PKA inhibitor
| Chemical Name: | 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine hydrochloride |
| Purity: | ≥98% (HPLC) |
AKT kinase Degrader (PROTAC®)
| Chemical Name: | 4-Amino-N-((S)-1-(4-chlorophenyl)-3-(4-(12-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-12-oxododecanoyl)piperazin-1-yl)propyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide |
| Purity: | ≥97% (HPLC) |
SPOP E3 ubiquitin ligase inhibitor
| Chemical Name: | 1,5-Dihydro-2-imino-10-methyl-N-[2-(4-methyl-1-piperazinyl)ethyl]-5-oxo-1-[2-(2-thienyl)ethyl]-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide |
| Purity: | ≥98% (HPLC) |
