Human/Mouse/Rat/Hamster ACE‑2 Antibody Best Seller

Name: Human/Mouse/Rat/Hamster ACE‑2 Antibody
Brand: R&D Systems
SKU: AF933
Rating: 5 (4 reviews)

Catalog # AF933 | R&D Systems, Inc. a Bio-Techne Brand

(4)

Citations (117)

Product Datasheet / COA / SDS

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Product Summary
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human, Mouse, Rat, Hamster

Applications

Blockade of Receptor-ligand Interaction, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Simple Western, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Product Summary for Human/Mouse/Rat/Hamster ACE‑2 Antibody

Immunogen

Mouse myeloma cell line NS0-derived recombinant human ACE-2
Gln18-Ser740
Accession # Q9BYF1

Specificity

Detects human ACE-2 in direct ELISAs. Detects human, mouse, and rat ACE-2 in Western blots. Detects Hamster ACE-2 in immunohistochemistry.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Human/Mouse/Rat/Hamster ACE‑2 Antibody

Detection of Human, Mouse, and Rat ACE‑2 by Western Blot.

Western blot shows lysates of human kidney tissue, mouse kidney tissue, and rat kidney tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat/Hamster ACE-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF933) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for ACE-2 at approximately 100 and 110 kDa (as indicated). This experiment was conducted under reducing conditions and using Western Blot Buffer Group 1.

Detection of ACE-2 in HEK293 Human Cell Line Transfected with Human ACE-2 and eGFP by Flow Cytometry.

HEK293 human embryonic kidney cell line transfected with (A) human ACE-2 or (B) irrelevant protein, and eGFP was stained with Goat Anti-Human/Mouse/Rat/Hamster ACE-2 Affinity Purified Polyclonal Antibody (Catalog # AF933) followed by Allophycocyanin-conjugated Anti-Goat IgG Secondary Antibody (F0108). Quadrant markers were set based on Goat IgG control antibody (AB-108-C, data not shown). Staining was performed using our Staining Membrane-associated Proteins protocol.

ACE‑2 in Human Kidney.

ACE-2 was detected in immersion fixed paraffin-embedded sections of human kidney using Goat Anti-Human/Mouse/Rat/Hamster ACE-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF933) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

ACE‑2 in Human Kidney.

ACE-2 was detected in immersion fixed paraffin-embedded sections of human kidney using Goat Anti-Human/Mouse/Rat/Hamster ACE-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF933) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

ACE‑2 in Hamster Lung.

ACE‑2 was detected in immersion fixed paraffin-embedded sections of hamster lung using Goat Anti-Human/Mouse/Rat/Hamster ACE‑2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF933) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to respiratory bronchioles. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

ACE‑2 in Rat Lung.

ACE‑2 was detected in immersion fixed frozen sections of rat lung using Goat Anti-Human/Mouse/Rat/Hamster ACE‑2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF933) at 10 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cell surface in eputhelial cells in bronchioles. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

ACE‑2 in Rat Lung.

ACE‑2 was detected in immersion fixed paraffin-embedded sections of rat lung using Goat Anti-Human/Mouse/Rat/Hamster ACE‑2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF933) at 10 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

ACE‑2 in Rat Kidney.

ACE‑2 was detected in immersion fixed paraffin-embedded sections of rat kidney using Goat Anti-Human/Mouse/Rat/Hamster ACE‑2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF933) at 10 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cell surface in convoluted tubules. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Detection of Human ACE‑2 by Simple Western^TM.

Simple Western lane view shows lysates of human kidney tissue, loaded at 0.2 mg/mL. A specific band was detected for ACE-2 at approximately 155 kDa (as indicated) using 10 µg/mL of Goat Anti-Human/Mouse/Rat/Hamster ACE-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF933) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

View 6 more images

Applications for Human/Mouse/Rat/Hamster ACE‑2 Antibody

Application

Recommended Usage

Blockade of Receptor-ligand Interaction

Hoffman, M. et al. (2020) Cell. DOI: 10.1016/j.cell.2020.02.052. This application was not tested by R&D Systems.

Flow Cytometry

0.25 µg/10⁶ cells
Sample: HEK293 Human Cell Line Transfected with Human ACE-2 and eGFP

Immunohistochemistry

3-15 µg/mL
Sample: Immersion fixed frozen sections of rat lung, immersion fixed paraffin-embedded sections of human kidney, hamster lung, rat lung, and rat kidney

Immunoprecipitation

25 µg/mL
Sample: Conditioned cell culture medium spiked with Recombinant Human ACE‑2 (Catalog # 933-ZN), see our available Western blot detection antibodies

Simple Western

10 µg/mL
Sample: Human kidney tissue

Western Blot

1 µg/mL
Sample: Human kidney tissue, Mouse kidney tissue, and Rat kidney tissue

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Reviewed Applications

Read 4 reviews rated 5 using AF933 in the following applications:

Block/Neutralize (1 Review)
Immunocytochemistry/Immunofluorescence (1 Review)
Immunofluorescence (1 Review)
Western Blot (1 Review)

Published Applications

Read 117 publications using AF933 in the following applications:

Co-Immunoprecipitation (2 Publications)
Control (1 Publication)
ELISA Detection (1 Publication)
FLOW (1 Publication)
Flow Cytometry (32 Publications)
ICC (26 Publications)
IHC (28 Publications)
IHC-Fr (1 Publication)
IHC-P (2 Publications)
Neutralization (15 Publications)
Western Blot (37 Publications)

Formulation, Preparation and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ACE-2

ACE-2, also called ACEH (ACE homolog), is an integral membrane protein and a zinc metalloprotease of the ACE family that also includes somatic and germinal ACE (1). Human ACE-2 has about 40% amino acid identity to the N- and C-terminal domains of human somatic ACE. The predicted human ACE-2 protein sequence consists of 805 amino acids, including a N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE-2 cleaves angiotensins I and II as a carboxypeptidase. ACE-2 mRNA is found at high levels in testis, kidney, and heart and at moderate levels in colon, small intestine, and ovary. Classical ACE inhibitors such as captopril and lisinopril do not inhibit ACE-2 activity. Novel peptide inhibitors of ACE-2 do not inhibit ACE activity (2). Genetic data from Drosophila, mice and rats show that ACE-2 is an essential regulator of heart function in vivo (3).

ACE2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2 (4, 5). This Human anti-ACE2 antibody (catalog # AF933) was used to block the variant SARS-CoV-2 and ACE2 interaction to elucidate viral transmission and potential therapeutic strategies. (5)

References

Tipnis, S.R. et al. (2000) J. Biol. Chem. 275:33238.
Crackower, M.A. et al. (2002) Nature 417:822.
Huang, L. et al. (2003) J. Biol. Chem. 278:15532.
Li, W. et al. (2003) Nature 426:450.
Hoffmann, M. et al. (2020) Cell. DOI: 10.1016/j.cell.2020.02.052.

Long Name

Angiotensin I Converting Enzyme 2

Alternate Names

ACE2, ACEH

Entrez Gene IDs

480847 (Canine); 418623 (Chicken); 102130864 (Cynomolgus Monkey); 554349 (Feline); 101673097 (Ferret); 101823817 (Hamster); 59272 (Human); 108390919 (Malayan Pangolin); 70008 (Mouse); 100144303 (Porcine); 302668 (Rat)

Gene Symbol

ACE2

UniProt

Q9BYF1

Product Documents for Human/Mouse/Rat/Hamster ACE‑2 Antibody

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for Human/Mouse/Rat/Hamster ACE‑2 Antibody

For research use only

Citations
Reviews

Citations for Human/Mouse/Rat/Hamster ACE‑2 Antibody (117)

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Citations are publications that use Bio-Techne products. Selected citations for Human/Mouse/Rat/Hamster ACE‑2 Antibody include:

Species: Human
Sample Types: Whole Cells
Applications: ICC

Minami et al. (2023-07-18), Effective SARS-CoV-2 replication of monolayers of intestinal epithelial cells differentiated from human induced pluripotent stem cells Scientific reports
PMID: 37463955
Species: Transgenic Mouse
Sample Types: Whole Tissue
Applications: IHC

Liu et al. (2023-06-20), An inducible hACE2 transgenic mouse model recapitulates SARS-CoV-2 infection and pathogenesis in vivo Proceedings of the National Academy of Sciences of the United States of America
PMID: 37307455
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

Khan et al. (2023-05-30), Generation of a SARS-CoV-2 Reverse Genetics System and Novel Human Lung Cell Lines That Exhibit High Virus-Induced Cytopathology Viruses
PMID: 37376581
Species: Human
Sample Types: Whole Cells
Applications: Neutralization

Barreto et al. (2023-05-23), COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis Proceedings of the National Academy of Sciences of the United States of America
PMID: 37186819
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

Kummarapurugu et al. (2023-05-13), Neutrophil Elastase decreases SARS-CoV-2 Spike protein binding to human bronchial epithelia by clipping ACE-2 ectodomian from the epithelial surface The Journal of biological chemistry
PMID: 37187291
Species: Human
Sample Types: Whole Cells
Applications: FLOW

M Ulinici et al. (2023-03-13), Characterisation of the Antibody Response in Sinopharm (BBIBP-CorV) Recipients and COVID-19 Convalescent Sera from the Republic of Moldova Vaccines, 2023-011(3).
PMID: 36992221
Species: Mouse
Sample Types: Whole Tissue,Tissue Homogenates
Applications: Western Blot,IHC

AT Tang et al. (2023-02-06), Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection PloS Biology, 2023-021(2):e3001989.
PMID: 36745682
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

N Tailor et al. (2022-12-28), Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 Gene Viruses, 2022-115(1).
PMID: 36680125
Species: Human
Sample Types: Whole Cells,Cell Lysates,Whole Tissue
Applications: Co-Immunoprecipitation,IHC,Flow Cytometry,Western Blot

A Miluzio et al. (2022-12-28), Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2 EBioMedicine, 2022-187(0):104390.
PMID: 36584595
Species: Human
Sample Types: Whole Cells
Applications: ICC

X Guo et al. (2022-12-23), Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2 Nature Communications, 2022-113(1):7907.
PMID: 36564389
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

Y Kato et al. (2022-12-21), TRPC3-Nox2 Protein Complex Formation Increases the Risk of SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through ACE2 Upregulation International Journal of Molecular Sciences, 2022-124(1).
PMID: 36613540
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

SB Biering et al. (2022-12-09), SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-beta signaling Nature Communications, 2022-113(1):7630.
PMID: 36494335
Species: Mink
Sample Types: Whole Tissue
Applications: IHC

DR Adney et al. (2022-11-22), Severe acute respiratory disease in American mink experimentally infected with SARS-CoV-2 JCI Insight, 2022-17(22).
PMID: 36509288
Species: Human,Bat
Sample Types: Whole Cells
Applications: Neutralization

H Guo et al. (2022-11-21), ACE2-Independent Bat Sarbecovirus Entry and Replication in Human and Bat Cells MBio, 2022-10(0):e0256622.
PMID: 36409074
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

J Song et al. (2022-10-13), LRRC15 inhibits SARS-CoV-2 cellular entry in trans PloS Biology, 2022-120(10):e3001805.
PMID: 36228039
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

K Shilagardi et al. (2022-10-05), The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation MBio, 2022-10(0):e0254322.
PMID: 36197088
Species: African Green Monkey
Sample Types: Whole Cells
Applications: ICC

TD Saccon et al. (2022-09-29), SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner Nature Communications, 2022-013(1):5722.
PMID: 36175400
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

N Brasu et al. (2022-09-22), Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination Nature Immunology, 2022-00(0).
PMID: 36138186
JV Harte et al. (2022-09-21), Metalloprotease-Dependent S2'-Activation Promotes Cell-Cell Fusion and Syncytiation of SARS-CoV-2 Viruses, 2022-014(10).
PMID: 36298651
Species: Human
Sample Types: Whole Cells
Applications: Control,ICC

M Montano et al. (2022-09-14), SARS-CoV-2 can infect human embryos Scientific Reports, 2022-012(1):15451.
PMID: 36104397
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

Y Yao et al. (2022-09-09), Surface translocation of ACE2 and TMPRSS2 upon TLR4/7/8 activation is required for SARS-CoV-2 infection in circulating monocytes Cell Discovery, 2022-08(1):89.
PMID: 36085197
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

J Hou et al. (2022-08-15), Integrated multi-omics analyses identify key anti-viral host factors and pathways controlling SARS-CoV-2 infection Research square, 2022-00(0).
PMID: 36032971
Species: Human,Mouse
Sample Types: Cell Lysates,Whole Tissue
Applications: Co-Immunoprecipitation,Western Blot,IHC

P Su et al. (2022-08-09), Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice Molecular Brain, 2022-015(1):71.
PMID: 35945596
Species: Human
Sample Types: Whole Cells
Applications: Neutralization

B Meng et al. (2022-08-03), SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity Cell Reports, 2022-040(7):111220.
PMID: 35963244
Species: Human
Sample Types: Whole Cells,Cell Lysates
Applications: ICC,Western Blot

Y Zhu et al. (2022-08-01), Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells PloS Biology, 2022-020(8):e3001728.
PMID: 35913989
Species: Human
Sample Types: Whole Tissue
Applications: IHC

H Stölting et al. (2022-07-15), Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1 Mucosal Immunology, 2022-00(0).
PMID: 35840680
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

CW Chang et al. (2022-06-23), A Newly Engineered A549 Cell Line Expressing ACE2 and TMPRSS2 Is Highly Permissive to SARS-CoV-2, Including the Delta and Omicron Variants Viruses, 2022-014(7).
PMID: 35891350
Species: Human
Sample Types: Whole Tissue
Applications: IHC

L Casciola-R et al. (2022-05-09), IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function JCI Insight, 2022-07(9).
PMID: 35349483
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry,Neutralization

C Junqueira et al. (2022-04-06), FcgammaR-mediated SARS-CoV-2 infection of monocytes activates inflammation Nature, 2022-00(0).
PMID: 35385861
Species: Human
Sample Types: Organoid
Applications: IHC

P Spitalieri et al. (2022-04-05), Two Different Therapeutic Approaches for SARS-CoV-2 in hiPSCs-Derived Lung Organoids Cells, 2022-011(7).
PMID: 35406799
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

M Ramal-Sanc et al. (2022-03-28), ACE2 Receptor and Its Isoform Short-ACE2 Are Expressed on Human Spermatozoa International Journal of Molecular Sciences, 2022-023(7).
PMID: 35409054
Species: Human
Sample Types: Organoid
Applications: Neutralization

Y Menuchin-L et al. (2022-03-24), SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids Stem Cell Reports, 2022-00(0).
PMID: 35334213
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

X Wang et al. (2022-02-17), Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung PloS Pathogens, 2022-018(2):e1010343.
PMID: 35176124
Species: Human
Sample Types: Whole Cells
Applications: Neutralization

S Krasemann et al. (2022-01-20), The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2 Stem Cell Reports, 2022-00(0).
PMID: 35063125
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

L El-Shennaw et al. (2022-01-20), Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Nature Communications, 2022-013(1):405.
PMID: 35058437
Species: Human
Sample Types: Whole Cells,Whole Tissue
Applications: IHC,ICC

J Grau-Expós et al. (2022-01-13), Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells PloS Pathogens, 2022-018(1):e1010171.
PMID: 35025963
Species: Human
Sample Types: Organoids
Applications: IHC

L Helms et al. (2021-12-22), Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations JCI Insight, 2021-10(0).
PMID: 34767537
Species: Human,Primate - C. aethiops
Sample Types: Whole Cells
Applications: Neutralization,Flow Cytometry

J Wang et al. (2021-12-14), SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells Cell Discovery, 2021-17(1):119.
PMID: 34903715
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

SB Biering et al. (2021-12-13), SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-beta signaling bioRxiv : the preprint server for biology, 2021-10(0).
PMID: 34931188
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA Detection

J Shi et al. (2021-11-24), Receptor-Binding Domain Proteins of SARS-CoV-2 Variants Elicited Robust Antibody Responses Cross-Reacting with Wild-Type and Mutant Viruses in Mice Vaccines, 2021-19(12).
PMID: 34960131
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

L Nguyen et al. (2021-11-09), Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2 Nature Chemical Biology, 2021-10(0).
PMID: 34754101
Species: Transgenic Mouse
Sample Types: Cell Lysates
Applications: Western Blot

MW Ku et al. (2021-10-25), Brain Cross-Protection against SARS-CoV-2 Variants by a Lentiviral Vaccine in New Transgenic Mice Embo Molecular Medicine, 2021-10(0):e14459.
PMID: 34647691
Species: Human
Sample Types: Organoids
Applications: IHC

X Duan et al. (2021-10-15), An airway organoid-based screen identifies a role for the HIF1alpha-glycolysis axis in SARS-CoV-2 infection Cell Reports, 2021-137(6):109920.
PMID: 34731648
Species: Human
Sample Types: Whole Tissue,Whole Cells
Applications: ICC,IHC

S Singh et al. (2021-09-25), SARS-CoV-2 and its variants of concern infect human conjunctival epithelial cells and induce differential antiviral innate immune response The ocular surface, 2021-00(0).
PMID: 34583089
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

R Tian et al. (2021-09-20), BRD2 inhibition blocks SARS-CoV-2 infection in vitro by reducing transcription of the host cell receptor ACE2 bioRxiv : the preprint server for biology, 2021-00(0).
PMID: 33501440
Species: Human
Sample Types: Whole Cells,Cell Lysates
Applications: Western Blot,Flow Cytometry

SP Shukla et al. (2021-08-20), "Molecular Masks" for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus Entry International Journal of Molecular Sciences, 2021-022(16).
PMID: 34445669
Species: Human
Sample Types: Whole Cells,Cell Lysates
Applications: Western Blot,Flow Cytometry

EJ Sherman et al. (2021-08-05), ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes Scientific Reports, 2021-011(1):15900.
PMID: 34354120
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

M Alenquer et al. (2021-08-05), Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies PloS Pathogens, 2021-017(8):e1009772.
PMID: 34352039
Species: Human
Sample Types: Whole Tissue
Applications: IHC

Y Kondo et al. (2021-07-22), L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus JCI Insight, 2021-06(14).
PMID: 34291736
Species: Human
Sample Types: Cell Lysates,Whole Cells
Applications: ICC,Western Blot

CLC Almeida-da et al. (2021-07-18), Cigarette Smoke Stimulates SARS-CoV-2 Internalization by Activating AhR and Increasing ACE2 Expression in Human Gingival Epithelial Cells International Journal of Molecular Sciences, 2021-022(14).
PMID: 34299289
Species: Human
Sample Types: Organoid
Applications: IHC

L Wang et al. (2021-07-09), A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology Nature Medicine, 2021-00(0).
PMID: 34244682
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

M Zhao et al. (2021-06-24), Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2 PloS Pathogens, 2021-017(6):e1009683.
PMID: 34166473
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

X Wang et al. (2021-06-23), Deletion of ER-retention motif on SARS-CoV-2 spike protein reduces cell hybrid during cell-cell fusion Cell & bioscience, 2021-011(1):114.
PMID: 34162440
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

M Puray-Chav et al. (2021-06-23), Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell Cell Reports, 2021-00(0):109364.
PMID: 34214467
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

M Baratchian et al. (2021-05-27), Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes Scientific Reports, 2021-011(1):11130.
PMID: 34045511
Species: Human
Sample Types: Whole Tissue
Applications: ICC

T Ebisudani et al. (2021-05-19), Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening Cell Reports, 2021-00(0):109218.
PMID: 34038715
Species: Human
Sample Types: Whole Tissue
Applications: IHC

AZ Eriksen et al. (2021-05-17), SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium Cell Stem Cell, 2021-00(0).
PMID: 34022129
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry,ICC

CH Chen et al. (2021-04-09), Deletion of ER-retention Motif on SARS-CoV-2 Spike Protein Reduces Cell Hybrid During Cell-cell Fusion Research square, 2021-00(0).
PMID: 33851149
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

M Dittmar et al. (2021-03-23), Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2 Cell Reports, 2021-035(1):108959.
PMID: 33811811
Species: Human
Sample Types: Cell Lysates,Whole Cells
Applications: Western Blot,Flow Cytometry

SJ Dicken et al. (2021-03-22), Characterisation of B.1.1.7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2 bioRxiv : the preprint server for biology, 2021-00(0).
PMID: 33791702
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

Y Zhang et al. (2021-03-15), SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication Nature Communications, 2021-012(1):1676.
PMID: 33723254
Species: Human
Sample Types: Cell Lysates,Whole Cells
Applications: Western Blot,Flow Cytometry

J Baggen et al. (2021-03-08), Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2 Nature Genetics, 2021-00(0).
PMID: 33686287
Species: Human,Primate
Sample Types: Whole Cells
Applications: Flow Cytometry,ICC

K Uemura et al. (2021-03-08), MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2 Scientific Reports, 2021-011(1):5376.
PMID: 33686154
Species: Rat
Sample Types: Whole Tissue,Tissue Homogenates
Applications: IHC

EE Khoury et al. (2021-03-04), Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease Journal of Cellular and Molecular Medicine, 2021-00(0).
PMID: 33660945
Species: Rat
Sample Types: Whole Tissue
Applications: IHC

S Sugimoto et al. (2021-02-24), An organoid-based organ-repurposing approach to treat short bowel syndrome Nature, 2021-00(0).
PMID: 33627870
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry,ICC

H Huerga Enc et al. (2021-02-05), Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients Stem Cell Reports, 2021-016(3):428-436.
PMID: 33581053
Species: Human
Sample Types: Whole Cells
Applications: ICC

X Yin et al. (2021-01-12), MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells Cell Reports, 2021-034(2):108628.
PMID: 33440148
Species: Human
Sample Types: Whole Cells
Applications: ICC

C Blume et al. (2021-01-11), A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection Nature Genetics, 2021-00(0).
PMID: 33432184
Species: Mesocricetus auratus (Hamster)
Sample Types: Whole Cells
Applications: Flow Cytometry

H Chu et al. (2021-01-08), Host and viral determinants for efficient SARS-CoV-2 infection of the human lung Nature Communications, 2021-012(1):134.
PMID: 33420022
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

F Onodi et al. (2021-01-08), SARS-CoV-2 induces human plasmacytoid pre-dendritic cell diversification via UNC93B and IRAK4 bioRxiv : the preprint server for biology, 2021-00(0).
PMID: 33442685
Species: Human
Sample Types: Whole Tissue,Whole Cells
Applications: IHC,ICC

AZ Mykytyn et al. (2021-01-04), SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site Elife, 2021-010(0).
PMID: 33393462
Species: Human
Sample Types: Organoid
Applications: ICC

RM Samuel et al. (2020-11-17), Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell, 2020-127(6):876-889.e12.
PMID: 33232663
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

JK Osan et al. (2020-11-12), Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in COPD bioRxiv, 2020-10(0).
PMID: 33200131
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

R Tandon et al. (2020-11-05), Effective screening of SARS-CoV-2 neutralizing antibodies in patient serum using lentivirus particles pseudotyped with SARS-CoV-2 spike glycoprotein Sci Rep, 2020-110(1):19076.
PMID: 33154514
Species: Human
Sample Types: Whole Tissue
Applications: IHC

IT Lee et al. (2020-10-28), ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs Nat Commun, 2020-111(1):5453.
PMID: 33116139
Species: Human
Sample Types: Whole Cells
Applications: ICC

W Rut et al. (2020-10-22), SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging Nat Chem Biol, 2020-10(0).
PMID: 33093684
Species: Primate
Sample Types: Whole Cells
Applications: Neutralization,ICC

X Xie et al. (2020-10-15), A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19 Nat Commun, 2020-111(1):5214.
PMID: 33060595
Species: Human
Sample Types: Protein
Applications: Western Blot

L Casciola-R et al. (2020-10-15), IgM autoantibodies recognizing ACE2 are associated with severe COVID-19 medRxiv, 2020-10(0).
PMID: 33083808
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

M Baratchian et al. (2020-10-14), Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2 bioRxiv, 2020-10(0).
PMID: 33083800
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

L Pellegrini et al. (2020-10-13), SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids Cell Stem Cell, 2020-10(0).
PMID: 33113348
Species: Human
Sample Types: Whole Tissue
Applications: IHC

SP Sajuthi et al. (2020-10-12), Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium Nat Commun, 2020-111(1):5139.
PMID: 33046696
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

R Wang et al. (2020-09-24), Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses bioRxiv : the preprint server for biology, 2020-00(0).
PMID: 32995787
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry,ICC

J Huang et al. (2020-09-18), SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response Cell Stem Cell, 2020-00(0).
PMID: 32979316
Species: Mouse,Human
Sample Types: Whole Tissue,Whole Cells
Applications: IHC,Neutralization

F Duan et al. (2020-09-15), Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2 Res Sq, 2020-00(0).
PMID: 32839764
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

I Busnadiego et al. (2020-09-10), Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2 MBio, 2020-011(5).
PMID: 32913009
Species: Human
Sample Types: Organoid
Applications: Neutralization

E Song et al. (2020-09-08), Neuroinvasion of SARS-CoV-2 in human and mouse brain bioRxiv : the preprint server for biology, 2020-00(0).
PMID: 32935108
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot

T Azad et al. (2020-08-30), Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization Membranes (Basel), 2020-010(9).
PMID: 32872641
Species: Human
Sample Types: Whole Cells
Applications: ICC,Flow Cytometry

J Huang et al. (2020-08-06), SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response bioRxiv, 2020-00(0).
PMID: 32637964
Species: Human
Sample Types: Whole Cells
Applications: ICC

J Prévost et al. (2020-07-30), Cross-sectional evaluation of humoral responses against SARS-CoV-2 Spike bioRxiv : the preprint server for biology, 2020-00(0).
PMID: 32577637
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

R Rathnasing et al. (2020-07-06), Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection bioRxiv, 2020-00(0).
PMID: 32676603
Species: Human
Sample Types: Whole Tissue,Tissue Homogenates
Applications: IHC,Western Blot

J Collin et al. (2020-06-03), Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface Ocul Surf, 2020-00(0).
PMID: 32502616
Species: Bat,Human
Sample Types: Whole Cells
Applications: ICC

J Zhou et al. (2020-05-13), Infection of bat and human intestinal organoids by SARS-CoV-2 Nat. Med., 2020-00(0).
PMID: 32405028
Species: Human
Sample Types: Whole Tissue
Applications: IHC

IT Lee et al. (2020-05-12), Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers medRxiv, 2020-00(0).
PMID: 32511516
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

KHD Crawford et al. (2020-05-06), Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays Viruses, 2020-012(5).
PMID: 32384820
Species: Human
Sample Types: Whole Cells
Applications: ICC

Y Han et al. (2020-05-05), Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids bioRxiv, 2020-00(0).
PMID: 32511403
Species: Mouse,Human
Sample Types: Cell Lysates,Tissue Homogenates
Applications: Western Blot

M Yang et al. (2020-04-08), Liraglutide Attenuates Non-Alcoholic Fatty Liver Disease in Mice by Regulating the Local Renin-Angiotensin System Front Pharmacol, 2020-011(0):432.
PMID: 32322207
Species: Primate - Chlorocebus aethiops (African Green Monkey)
Sample Types: Whole Cells
Applications: Neutralization

Hoffmann M et al. (2020-03-05), SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell, 2020-0181(0):1-10.
PMID: 32142651
Species: Rhesus Macaca (Macaque)
Sample Types: Whole Tissue
Applications: IHC-P

D Tian et al. (2019-06-24), Protective effects of the Francisella tularensis Î´pdpC mutant against its virulent parental strain SCHU P9 in Cynomolgus macaques Sci Rep, 2019-09(1):9193.
PMID: 31235714
Species: Human
Sample Types: Cell Lysates,Whole Cells
Applications: Western Blot,Flow Cytometry

E Schrom et al. (2017-04-13), Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA Mol Ther Nucleic Acids, 2017-07(0):350-365.
PMID: 28624211
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot

Fengxia Xiao et al. (2016-06-01), Protein Kinase C-? Mediates Shedding of Angiotensin-Converting Enzyme 2 from Proximal Tubular Cells. Frontiers in Pharmacology, 2016-00(0):1663-9812.
PMID: 27313531
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: IHC

Aleksandra Milewska (2016-06-01), HTCC: Broad Range Inhibitor of Coronavirus Entry PLoS ONE, 2016-011(6):e0156552.
PMID: 27249425
Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Whole Cells
Applications: Neutralization

Yu Y et al. (2016-01-22), Surface vimentin is critical for the cell entry of SARS-CoV. J Biomed Sci, 2016-023(1):14.
PMID: 26801988
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot

Xiao F et al. (2014-01-15), Characterization of angiotensin-converting enzyme 2 ectodomain shedding from mouse proximal tubular cells. PLoS ONE, 2014-09(1):e85958.
PMID: 24454948
Species: Human
Sample Types: Whole Tissue
Applications: IHC

Eckerle I et al. (2013-12-23), In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection. Virol J, 2013-110(0):359.
PMID: 24364985
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

Heurich A et al. (2013-11-13), TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. J Virol, 2013-188(2):1293-307.
PMID: 24227843
Species: Bat,Human,Civet
Sample Types: Whole Cells
Applications: IHC

Ge et al. (2013-10-30), Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature, 2013-1503(7477):535-8.
PMID: 24172901
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P

Bertram S et al. (2012-04-30), Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts. PLoS ONE, 2012-07(4):e35876.
PMID: 22558251
Species: Mouse
Sample Types: Whole Tissue,Tissue Homogenates
Applications: Western Blot,IHC-Fr

Pohl M et al. (2010-10-21), Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron. J. Biol. Chem., 2010-1285(53):41935-46.
PMID: 20966072
Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Cell Lysates
Applications: Western Blot

Glende J et al. (2008-09-23), Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2. Virology, 2008-0381(2):215-21.
PMID: 18814896
Species: Human
Sample Types: Plasma
Applications: Neutralization

Epelman S et al. (2008-08-26), Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system. J. Am. Coll. Cardiol., 2008-052(9):750-4.
PMID: 18718423
Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Whole Cells
Applications: Flow Cytometry

Lu Y et al. (2008-02-13), Lipid rafts are involved in SARS-CoV entry into Vero E6 cells. Biochem. Biophys. Res. Commun., 2008-0369(2):344-9.
PMID: 18279660
Species: Human
Sample Types: Whole Cells,Cell Lysates
Applications: ICC,Western Blot

Ren W et al. (2007-12-12), Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin. J. Virol., 2007-182(4):1899-907.
PMID: 18077725
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Cell Lysates
Applications: Western Blot

Inoue Y et al. (2007-05-23), Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted. J. Virol., 2007-081(16):8722-9.
PMID: 17522231
Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Whole Cells
Applications: Neutralization

Rockx B et al. (2007-05-16), Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice. J. Virol., 2007-081(14):7410-23.
PMID: 17507479
Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Whole Cells
Applications: ICC

de Lang A et al. (2006-07-24), Interferon-gamma and interleukin-4 downregulate expression of the SARS coronavirus receptor ACE2 in Vero E6 cells. Virology, 2006-0353(2):474-81.
PMID: 16860835
Species: Human
Sample Types: Whole Cells
Applications: ICC,Neutralization

Tseng CT et al. (2005-08-01), Apical entry and release of severe acute respiratory syndrome-associated coronavirus in polarized Calu-3 lung epithelial cells. J. Virol., 2005-079(15):9470-9.
PMID: 16014910
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry

Hofmann H et al. (2004-07-09), Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor. Biochem. Biophys. Res. Commun., 2004-0319(4):1216-21.
PMID: 15194496

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Human/Mouse/Rat/Hamster ACE-2 Antibody

Name: Anonymous

Application: Block/Neutralize

Sample Tested: Embryonic lung

Species: Human

Verified Customer | Posted 10/04/2022
Human/Mouse/Rat/Hamster ACE-2 Antibody

Name: Yuchen Liu

Application: Immunocytochemistry/Immunofluorescence

Sample Tested: Stimulated Human Bronchial Epithelial Cell Line (BEAS-2B)

Species: Human

Verified Customer | Posted 03/09/2021
Human ACE-2 Antibody

Name: Anonymous

Application: Western Blot

Sample Tested: Human CD34+ Cells and Blood mononuclear cells (PBMCs)

Species: Human

Verified Customer | Posted 08/12/2016
Name: Anonymous

Application: Immunofluorescence

Sample Tested: See PMID 23232719

Species: Human

Verified Customer | Posted 01/12/2015

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Detection of Human, Mouse, and Rat ACE‑2 by Western Blot.

Detection of ACE-2 in HEK293 Human Cell Line Transfected with Human ACE-2 and eGFP by Flow Cytometry.

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