NK1R: Small Molecules and Peptides
NK1R (Neurokinin-1 receptor), gene name TACR1 (tachykinin receptor-1), is a 100 kDa 7-transmembrane glycoprotein receptor for the proinflammatory tachykinin neuropeptide, substance P. NK1R is constitutively or inducibly expressed on a wide variety of cells, including monocytes, macrophages, microglia, lymphocytes, neutrophils, mast cells, and neurons.
16 results for "NK1R Small Molecules and Peptides" in Products
16 results for "NK1R Small Molecules and Peptides" in Products
NK1R: Small Molecules and Peptides
NK1R (Neurokinin-1 receptor), gene name TACR1 (tachykinin receptor-1), is a 100 kDa 7-transmembrane glycoprotein receptor for the proinflammatory tachykinin neuropeptide, substance P. NK1R is constitutively or inducibly expressed on a wide variety of cells, including monocytes, macrophages, microglia, lymphocytes, neutrophils, mast cells, and neurons.
Sensory neuropeptide; inflammatory mediator
| Purity: | ≥95% (HPLC) |
MRGPRX2 antagonist; also NK1 receptor antagonist
| Purity: | ≥90% (HPLC) |
Potent long-acting hNK1 antagonist
| Chemical Name: | 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one |
| Purity: | ≥98% (HPLC) |
Potent NK1 antagonist
| Chemical Name: | (2S,3S)-3-[[3,5-bis(Trifluoromethyl)phenyl]methoxy]-2-phenylpiperidine hydrochloride |
| Purity: | ≥98% (HPLC) |
High affinity NK1 antagonist
| Chemical Name: | (2S,3S)-N-[(2-Methoxyphenyl)methyl]-2-phenyl-3-piperidinamine dihydrochloride |
| Purity: | ≥98% (HPLC) |
High affinity NK1 antagonist
| Chemical Name: | 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl-N,N-dimethyl-1H-1,2,3-triazole-4-methanamine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective NK1 antagonist
| Chemical Name: | (3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol |
| Purity: | ≥97% (HPLC) |
Potent and selective NK1 agonist
| Purity: | ≥95% (HPLC) |
High affinity NK1 antagonist
| Chemical Name: | (4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide |
| Purity: | ≥98% (HPLC) |
Potent and selective NK1 agonist
| Purity: | ≥95% (HPLC) |
Potent and selective NK1 antagonist
| Chemical Name: | (2S,3S)-N-(2-Methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant
| Chemical Name: | 3-(2,3-Difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine |
| Purity: | ≥98% (HPLC) |
Potent NK1 antagonist
| Chemical Name: | 1-[2-[(3S)-3-(3,4-Dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride |
| Purity: | ≥97% (HPLC) |
High affinity NK1 antagonist
| Chemical Name: | (2S,3S)-N-[[2-Methoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride |
| Purity: | ≥98% (HPLC) |
Highly selective human NK1 antagonist
| Chemical Name: | 1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide |
| Purity: | ≥98% (HPLC) |
Potent and selective NK1 antagonist
| Chemical Name: | (2S,3S)-N-[[2-Methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride |
| Purity: | ≥98% (HPLC) |
