CP 96345
Tocris Bioscience, part of Bio-Techne | Catalog # 2893
Potent and selective NK1 antagonist
Key Product Details
Description
Potent and selective NK1 antagonist
Product Description
CP 96345 is a potent and selective non-peptide NK1 receptor antagonist. Attenuates substance P-induced salivary response and inhibits neurogenic inflammation in vivo.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
412.57
Formula
C28H32N2O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S,3S)-N-(2-Methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine
CAS Number
132746-60-2
PubChem ID
104943
InChI Key
FLNYLINBEZROPL-NSOVKSMOSA-N
SMILES
COC(C=CC=C3)=C3CN[C@H]1C(CC4)CCN4[C@H]1[C@H](C5=CC=CC=C5)C2=CC=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.25 | 20 with gentle warming |
Preparing Stock Solutions
for CP 96345
The following data is based on the product molecular weight 412.57
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.12 mL | 60.60 mL | 121.19 mL |
| 1 mM | 2.42 mL | 12.12 mL | 24.24 mL |
| 2 mM | 1.21 mL | 6.06 mL | 12.12 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lembeck The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation. Br.J.Pharmacol. 1992 PMID: 1378337
- Bang Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. J.Pharmacol.Exp.Ther. 2003 PMID: 12649350
- Snider A potent nonpeptide antagonist of the substance P (NK1) receptor. Science 1991 PMID: 1703323
Product Specific Notices for CP 96345
For research use only
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