GR 73632
Tocris Bioscience, part of Bio-Techne | Catalog # 1669
Potent and selective NK1 agonist
Product Description
GR 73632 is a potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens). Active in vivo. Intrathecal administration of GR 73632 in mice increases itch behavior.Licensing Information
Sold for research purposes under agreement from GlaxoSmithKlineProduct Specifications
Molecular Weight
766.01
Formula
C40H59N7O6S
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
133156-06-6
PubChem ID
119599
InChI Key
HQKPTSSZOJLFBZ-LJADHVKFSA-N
SMILES
[H]N([C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(=O)CCCCN
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sheahan The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch. J.Neurosci. 2021 PMID: 33051347
- Meini GR 73,632 and [glu(OBzl)11]substance P are selective agonists for the septide-sensitive tachykinin NK1 receptor in the rat urinary bladder. Neuropeptides 1995 PMID: 7538205
- Sakurada Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist. Peptides 1999 PMID: 10422886
- Hall and Morton Novel ligands confirm NK-1 receptor-mediated modulation of neurotransmission in the guinea pig vas deferens preparation. Ann.N.Y.Acad.Sci. 1991 PMID: 1719888
Product Specific Notices for GR 73632
For research use only
Loading...
Loading...