QWF
Tocris Bioscience, part of Bio-Techne | Catalog # 6642
MRGPRX2 antagonist; also NK1 receptor antagonist
Key Product Details
Description
MRGPRX2 antagonist; also NK1 receptor antagonist
Product Description
QWF is a tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo. QWF can be used in a small molecule cocktail to generate 3D culture of lung alveolar cells (see protocol below).For more information about how QWF may be used, see our protocol: 3D Culture of Lung Alveolar Cells
Product Specifications
Molecular Weight
697.78
Formula
C38H43N5O8
Storage
Store at -20°C
Purity
≥90% (HPLC)
CAS Number
126088-82-2
PubChem ID
336446954
InChI Key
ZFZOHFAASQHWER-NCRUWMDKNA-N
SMILES
CC(C)(C)OC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CN(C=O)C2=CC=CC=C12)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OCC1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 10mg/ml in DMSO |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Azimi Dual action of neurokinin-1 antagonists on Mas-related GPCRs. JCI Insight. 2016 PMID: 27734033
- Hagiwara Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists. J.Med.Chem. 1992 PMID: 1375965
Product Specific Notices for QWF
For research use only
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