20 results for "Mitosis-Related Compounds Small Molecules and Peptides" in Products
Mitosis-Related Compounds: Small Molecules and Peptides
Mitosis is a highly complex and regulated sequence of events that occurs exclusively in eukaryotic cells and produces two identical daughter cells from a single parent cell.
Mitosis is split into five phases:
- Prophase - Chromatin condenses to form chromosomes. Centrosomes begin to migrate to opposite poles of the cell.
- Prometaphase - The nuclear envelope breaks down and centrosomes are situated at opposite poles of the cell. Sister chromatids attach to the microtubule spindles.
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Non-competitive dynamin inhibitor
| Chemical Name: | 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide |
| Purity: | ≥98% (HPLC) |
Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis
| Chemical Name: | 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone |
| Purity: | ≥98% (HPLC) |
DNA polymerase α, δ and ε inhibitor
| Chemical Name: | (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol |
| Purity: | ≥98% (HPLC) |
Promotes assembly and inhibits disassembly of microtubules
| Alternate Names: | Paclitaxel |
| Chemical Name: | [2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid |
| Purity: | ≥98% (HPLC) |
Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1
| Alternate Names: | SL-2052 |
| Chemical Name: | (1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6,9-trione |
| Purity: | ≥98% (HPLC) |
Microtubule inhibitor
| Chemical Name: | [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbamic acid methyl ester |
| Purity: | ≥95% (HPLC) |
Inhibits Aurora kinase B
| Chemical Name: | N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide |
| Purity: | ≥98% (HPLC) |
Inhibitor of tubulin
| Chemical Name: | (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide |
| Purity: | ≥98% (HPLC) |
Cell-permeable APC/C inhibitor
| Chemical Name: | Methyl (2S)-2-[[(4-methylphenyl)sulfonyl]amino]-9,13-dioxo-14-phenyl-7-[[[[(2-phenylacetyl)oxy]methoxy]carbonyl]amino]-10,12-dioxa-6,8-diazatetradec-6-enoate |
| Purity: | ≥90% (HPLC) |
Disrupts microtubules
| Chemical Name: | 22-Oxovincaleukoblastine |
| Purity: | ≥95% (HPLC) |
Disrupts microtubules
| Chemical Name: | Vincaleukoblastine |
| Purity: | ≥95% (HPLC) |
Selective inhibitor of mitotic kinesin Eg5
| Chemical Name: | 1,2,3,4-Tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester |
| Purity: | ≥98% (HPLC) |
Potent and selective PLK2 inhibitor
| Chemical Name: | 3-(1,3-Benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-isoxazolo[5,4-c]pyridin-5-amine |
| Purity: | ≥98% (HPLC) |
Potent, selective and irreversible protein phosphatase methylesterase-1 (PME-1) inhibitor
| Chemical Name: | (2E)-2-[(4-Fluorophenyl)sulfonyl]-3-[1-[(3-nitrophenyl)sulfonyl]-1H-pyrrol-2-yl]-2-propenenitrile |
| Purity: | ≥98% (HPLC) |
High affinity and selective PLK4 inhibitor
| Chemical Name: | 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-4-pyrimidinamine |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of PLK1 and PLK3
| Chemical Name: | 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide |
| Purity: | ≥98% (HPLC) |
Selective and ATP-competitive Kif18A inhibitor
| Chemical Name: | 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene |
| Purity: | ≥98% (HPLC) |
CXCR4 antagonist; antitumor
| Purity: | ≥95% (HPLC) |
Potent and selective PLK1 inhibitor
| Chemical Name: | 4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)benzamide hydrochloride |
| Purity: | ≥98% (HPLC) |
High affinity and selective PLK4 inhibitor
| Alternate Names: | LCR 323 |
| Chemical Name: | 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine |
| Purity: | ≥98% (HPLC) |
