proTAME
Tocris Bioscience, part of Bio-Techne | Catalog # 7734
Cell-permeable APC/C inhibitor
Product Description
ProTAME is a cell-permeable APC/C (anaphase-promoting complex/cyclosome) inhibitor. It is converted to TAME (Tosyl-L-Arginine Methyl Ester) by intracellular esterases. It induces cell cycle arrest in metaphase followed by cell death.Product Specifications
Molecular Weight
726.75
Formula
C34H38N4O12S
Storage
Store at -20°C
Purity
≥90% (HPLC)
Chemical Name
Methyl (2S)-2-[[(4-methylphenyl)sulfonyl]amino]-9,13-dioxo-14-phenyl-7-[[[[(2-phenylacetyl)oxy]methoxy]carbonyl]amino]-10,12-dioxa-6,8-diazatetradec-6-enoate
CAS Number
1362911-19-0
PubChem ID
56924780
InChI Key
MHYOVHULCQSDRZ-NDEPHWFRSA-N
SMILES
O=C([C@@H](NS(=O)(C1=CC=C(C=C1)C)=O)CCC/N=C(NC(OCOC(CC2=CC=CC=C2)=O)=O)/NC(OCOC(CC3=CC=CC=C3)=O)=O)OC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.34 | 50 |
Preparing Stock Solutions
for proTAME
The following data is based on the product molecular weight 726.75
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.75 mL | 13.76 mL | 27.52 mL |
| 2.5 mM | 0.55 mL | 2.75 mL | 5.50 mL |
| 5 mM | 0.28 mL | 1.38 mL | 2.75 mL |
| 25 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zeng Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell 2010 PMID: 20951947
Product Specific Notices for proTAME
For research use only
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