Key Product Details
Description: | Promotes assembly and inhibits disassembly of microtubules |
Alternative Names: | Paclitaxel |
Chemical Name: | [2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 853.92 |
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Citations for Taxol (28)
Citations are publications that use Bio-Techne products. Selected citations for Taxol include:
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Villalba-Riquelme et al.
(2022)
Paclitaxel in vitro reversibly sensitizes the excitability of IB4(-) and IB4(+) sensory neurons from male and female rats.
Br.J.Pharmacol..
179:3693
PMID: 35102580 -
Wang et al.
(2019)
Programmed cell death factor 4 enhances the chemosensitivity of colorectal cancer cells to Taxol.
Oncol Lett.
18:1402
PMID: 31423204 -
Kyte et al.
(2018)
Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN.
J Pharmacol Exp Ther.
364:110
PMID: 29042416 -
Zhang
(2017)
The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
Mol Cancer Ther.
16(6):1021
PMID: 28265007 -
Ayoub
(2017)
Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents.
Onco Targets Ther.
10:4869
PMID: 29042798 -
Wang et al.
(2017)
Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells.
Elife.
6
PMID: 28906251 -
Rennekamp et al.
(2016)
σ1 receptor ligands control a switch between passive and active threat responses.
Nat Chem Biol.
12:552
PMID: 27239788 -
Masocha
(2016)
Gene expression profile of sodium channel subunits in the anterior cingulate cortex during experimental paclitaxel-induced neuropathic pain in mice.
PeerJ.
4:e2702
PMID: 27896032 -
Masocha
(2015)
Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during PacT.-induced neuropathic pain in mice.
PeerJ.
3:e1350
PMID: 26528412 -
Haghshenas et al.
(2015)
Bioactivity characterization of Lactobacillus strains isolated from dairy products.
Microbiologyopen.
4:803
PMID: 26219634 -
Stephan et al.
(2015)
Biopolymer implants enhance the efficacy of adoptive T-cell therapy.
PLoS One.
33:97
PMID: 25503382 -
Goldmacher et al.
(2015)
High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction.
Plant Signal Behav.
10:e0117523
PMID: 25671541 -
Akita et al.
(2015)
Quantitative analysis of microtubule orientation in interdigitated leaf pavement cells.
Int J Mol Sci.
10:e1024396
PMID: 26039484 -
Vergara et al.
(2015)
Transgenic plants as low-cost platform for chemotherapeutic drugs screening.
Chin J Cancer.
16:2174
PMID: 25608652 -
Kathawala et al.
(2015)
ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel.
J Cell Sci.
34:115
PMID: 25962593 -
Parvathy and Masocha
(2015)
Coadministration of indomet. and MinCyc attenuates established PacT.-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors.
Proc Natl Acad Sci U S A.
5:10541
PMID: 26085115 -
Kathawala et al.
(2015)
The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study.
Oncotarget.
6:510
PMID: 25402202 -
Nagro et al.
(2014)
Depletion of the central metabolite NAD leads to oncosis-mediated cell death.
Nat Biotechnol.
289:35182
PMID: 25355314 -
Floyd et al.
(2013)
Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1.
EMBO J.
126:2845
PMID: 23613471 -
Habu and Matsumoto
(2013)
p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs.
Sci Rep.
2:562
PMID: 24255856 -
Lin et al.
(2012)
PacT. and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells.
Br J Cancer.
107:1692
PMID: 23037716 -
Natrajan et al.
(2012)
Functional characterization of the 19q12 amplicon in grade III breast cancers.
Breast Cancer Res.
14:R53
PMID: 22433433 -
Gärtner et al.
(2012)
N-cadherin specifies first asymmetry in developing neurons.
Springerplus.
31:1893
PMID: 22354041 -
Hahm et al.
(2011)
Substance P induces the reversible formation of varicosities in the dendrites of rat brainstem neurons.
Brain Res.
1369:36
PMID: 21044613 -
He et al.
(2010)
Leading tip drives som. translocation via forward F-actin flow during neuronal migration.
J Neurosci.
30:10885
PMID: 20702717 -
Lim et al.
(2009)
Alpha-tocopheryl succinate potentiates the PacT.-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells.
Exp Mol Med.
41:737
PMID: 19561399 -
Nieto et al.
(2008)
Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice
Pain.
137:520
PMID: 18037242 -
Pennati et al.
(2005)
Potentiation of PacT.-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.
Mol Cancer Ther.
4:1328
PMID: 16170024
There are no citations that match your criteria.
Customer Reviews for Taxol (2)
Customer Images
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Species: HumanAssay Type: In VitroTaxol was used for the establishment of taxol-resistant pancreatic cancer cell lines.
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Species: MouseAssay Type: In VivoCell Line/Tissue: Human epidermal carcinoma cell lineHuman epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.
There are no reviews that match your criteria.
⚠ WARNING: This product can expose you to chemicals including Paclitaxel, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov