Taxol
Tocris Bioscience, part of Bio-Techne | Catalog # 1097
Promotes assembly and inhibits disassembly of microtubules
Key Product Details
Description
Promotes assembly and inhibits disassembly of microtubules
Alternative Names
Paclitaxel
Product Description
Taxol, also known as paclitaxel, promotes and stabilizes tubulin polymerization, causing cell cycle arrest. In CCRF-HSB-2 cells, Taxol induces autocatalytic activation of caspase-10, triggering apoptosis. Taxol is an antitumor agent. In a mouse model of bladder cancer Taxol decreases tumor growth. Taxol also prolongs survival of mice transplanted with human ovarian carcinoma xenografts. Taxol improves neurological outcome and magnetic resonance imaging biomarkers after traumatic brain injury in mice.Product Specifications
Molecular Weight
853.92
Formula
C47H51NO14
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
[2aR-[2aα,4β,4aβ,6α,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid
CAS Number
33069-62-4
PubChem ID
441276
InChI Key
RCINICONZNJXQF-VAZQATRQSA-N
SMILES
O=C2[C@@]3(C)C([C@@]4(OC(C)=O)[C@H](OC4)C[C@@H]3O)[C@H](OC(C7=CC=CC=C7)=O)[C@@]1(O)[C@](C)(C)C([C@H]2OC(C)=O)=C(C)[C@@H](OC([C@H](O)[C@H]([C@]5=CC=CC=C5)NC(C6=CC=CC=C6)=O)=O)C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 85.39 | 100 with gentle warming | |
| Ethanol | 21.35 | 25 with gentle warming |
Preparing Stock Solutions
for Taxol
The following data is based on the product molecular weight 853.92
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.17 mL | 5.86 mL | 11.71 mL |
| 5 mM | 0.23 mL | 1.17 mL | 2.34 mL |
| 10 mM | 0.12 mL | 0.59 mL | 1.17 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nicoletti Antitumor activity of Tax. (NSC-125973) in human ovarian carcinomas growing in the peritoneal cavity of nude mice. Ann.Oncol. 1993 PMID: 8095399
- Cross PacT improves outcome from traumatic brain injury. Brain Res. 2015 PMID: 26086366
- Rao Characterization of the Tax. binding site on the microtubule. J.Biol.Chem. 1999 PMID: 10608867
- Park Taxol induces caspase-10-dependent apoptosis. J.Biol.Chem. 2004 PMID: 15452117
- McGuire Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann.Intern.Med. 1989 PMID: 2569287
- Rowinsky Taxol: a novel investigational antimicrotubule agent. J.Natl.Cancer Inst. 1990 PMID: 1973737
Product Specific Notices for Taxol
For research use only
⚠ WARNING: This product can expose you to chemicals including Paclitaxel, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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