Taxol

Tocris Bioscience a Bio-Techne Brand

Catalog # 1097

Citations (28)

(2)

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Key Product Details

Description:	Promotes assembly and inhibits disassembly of microtubules
Alternative Names:	Paclitaxel
Chemical Name:	[2aR-[2aα,4β,4aβ,6α,9α(αR,βS),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	853.92

View Full Technical Details for Taxol

Biological Activity for Taxol

Taxol, also known as paclitaxel, promotes and stabilizes tubulin polymerization, causing cell cycle arrest. In CCRF-HSB-2 cells, Taxol induces autocatalytic activation of caspase-10, triggering apoptosis. Taxol is an antitumor agent. In a mouse model of bladder cancer Taxol decreases tumor growth. Taxol also prolongs survival of mice transplanted with human ovarian carcinoma xenografts. Taxol improves neurological outcome and magnetic resonance imaging biomarkers after traumatic brain injury in mice.

Compound Libraries for Taxol

Taxol is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Taxol

M. Wt	853.92
Formula	C₄₇H₅₁NO₁₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	33069-62-4
PubChem ID	441276
InChi Key	RCINICONZNJXQF-VAZQATRQSA-N
Smiles	O=C2[C@@]3(C)C([C@@]4(OC(C)=O)[C@H](OC4)C[C@@H]3O)[C@H](OC(C7=CC=CC=C7)=O)[C@@]1(O)[C@](C)(C)C([C@H]2OC(C)=O)=C(C)[C@@H](OC([C@H](O)[C@H]([C@]5=CC=CC=C5)NC(C6=CC=CC=C6)=O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Taxol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	21.35	25 with gentle warming
	DMSO	85.39	100 with gentle warming

Preparing Stock Solutions for Taxol

The following data is based on the product molecular weight 853.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.17 mL	5.86 mL	11.71 mL
5 mM	0.23 mL	1.17 mL	2.34 mL
10 mM	0.12 mL	0.59 mL	1.17 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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References for Taxol

References are publications that support the biological activity of the product.

Cross PacT improves outcome from traumatic brain injury. Brain Res. 2015 PMID: 26086366
Park Taxol induces caspase-10-dependent apoptosis. J.Biol.Chem. 2004 PMID: 15452117
Rao Characterization of the Tax. binding site on the microtubule. J.Biol.Chem. 1999 PMID: 10608867
Nicoletti Antitumor activity of Tax. (NSC-125973) in human ovarian carcinomas growing in the peritoneal cavity of nude mice. Ann.Oncol. 1993 PMID: 8095399
Rowinsky Taxol: a novel investigational antimicrotubule agent. J.Natl.Cancer Inst. 1990 PMID: 1973737
McGuire Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann.Intern.Med. 1989 PMID: 2569287

Citations for Taxol (28)

Showing 1 - 10 of 28 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Taxol include:

Villalba-Riquelme et al. (2022) Paclitaxel in vitro reversibly sensitizes the excitability of IB4(-) and IB4(+) sensory neurons from male and female rats. Br.J.Pharmacol.. 179:3693
PMID: 35102580
Wang et al. (2019) Programmed cell death factor 4 enhances the chemosensitivity of colorectal cancer cells to Taxol. Oncol Lett. 18:1402
PMID: 31423204
Kyte et al. (2018) Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN. J Pharmacol Exp Ther. 364:110
PMID: 29042416
Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther. 16(6):1021
PMID: 28265007
Ayoub (2017) Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents. Onco Targets Ther. 10:4869
PMID: 29042798
Wang et al. (2017) Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells. Elife. 6
PMID: 28906251
Rennekamp et al. (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol. 12:552
PMID: 27239788
Masocha (2016) Gene expression profile of sodium channel subunits in the anterior cingulate cortex during experimental paclitaxel-induced neuropathic pain in mice. PeerJ. 4:e2702
PMID: 27896032
Masocha (2015) Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during PacT.-induced neuropathic pain in mice. PeerJ. 3:e1350
PMID: 26528412
Haghshenas et al. (2015) Bioactivity characterization of Lactobacillus strains isolated from dairy products. Microbiologyopen. 4:803
PMID: 26219634
Stephan et al. (2015) Biopolymer implants enhance the efficacy of adoptive T-cell therapy. PLoS One. 33:97
PMID: 25503382
Goldmacher et al. (2015) High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction. Plant Signal Behav. 10:e0117523
PMID: 25671541
Akita et al. (2015) Quantitative analysis of microtubule orientation in interdigitated leaf pavement cells. Int J Mol Sci. 10:e1024396
PMID: 26039484
Vergara et al. (2015) Transgenic plants as low-cost platform for chemotherapeutic drugs screening. Chin J Cancer. 16:2174
PMID: 25608652
Kathawala et al. (2015) ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel. J Cell Sci. 34:115
PMID: 25962593
Parvathy and Masocha (2015) Coadministration of indomet. and MinCyc attenuates established PacT.-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors. Proc Natl Acad Sci U S A. 5:10541
PMID: 26085115
Kathawala et al. (2015) The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study. Oncotarget. 6:510
PMID: 25402202
Nagro et al. (2014) Depletion of the central metabolite NAD leads to oncosis-mediated cell death. Nat Biotechnol. 289:35182
PMID: 25355314
Floyd et al. (2013) Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1. EMBO J. 126:2845
PMID: 23613471
Habu and Matsumoto (2013) p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs. Sci Rep. 2:562
PMID: 24255856
Lin et al. (2012) PacT. and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells. Br J Cancer. 107:1692
PMID: 23037716
Natrajan et al. (2012) Functional characterization of the 19q12 amplicon in grade III breast cancers. Breast Cancer Res. 14:R53
PMID: 22433433
Gärtner et al. (2012) N-cadherin specifies first asymmetry in developing neurons. Springerplus. 31:1893
PMID: 22354041
Hahm et al. (2011) Substance P induces the reversible formation of varicosities in the dendrites of rat brainstem neurons. Brain Res. 1369:36
PMID: 21044613
He et al. (2010) Leading tip drives som. translocation via forward F-actin flow during neuronal migration. J Neurosci. 30:10885
PMID: 20702717
Lim et al. (2009) Alpha-tocopheryl succinate potentiates the PacT.-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells. Exp Mol Med. 41:737
PMID: 19561399
Nieto et al. (2008) Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice Pain. 137:520
PMID: 18037242
Pennati et al. (2005) Potentiation of PacT.-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 4:1328
PMID: 16170024

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Customer Reviews for Taxol (2)

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Establishment of chemoresistant cells lines

Name: MARINA KOUTSIOUMPA

Species: Human

Assay Type: In Vitro

Taxol was used for the establishment of taxol-resistant pancreatic cancer cell lines.
Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma

Name: Anonymous

Species: Mouse

Assay Type: In Vivo

Cell Line/Tissue: Human epidermal carcinoma cell line

Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.

PMID: 28265007

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Product Documents for Taxol

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Paclitaxel, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov