HIF-1 alpha/HIF1A: Small Molecules and Peptides
The hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha/HIF1A) is the regulated member of the transcription factor heterodimer HIF-1 alpha/beta. HIF-1 alpha/HIF1A binds to hypoxia-response elements (HREs) in the promoters of many genes involved in the adaptation to an environment of insufficient oxygen or hypoxia. Hypoxic tissue environments occur in vascular and pulmonary diseases as well as cancer, which illustrates the broad impact of gene regulation by HIF1A.
Products:
8 results for "HIF-1 alpha/HIF1A Small Molecules and Peptides" in Products
8 results for "HIF-1 alpha/HIF1A Small Molecules and Peptides" in Products
HIF-1 alpha/HIF1A: Small Molecules and Peptides
The hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha/HIF1A) is the regulated member of the transcription factor heterodimer HIF-1 alpha/beta. HIF-1 alpha/HIF1A binds to hypoxia-response elements (HREs) in the promoters of many genes involved in the adaptation to an environment of insufficient oxygen or hypoxia. Hypoxic tissue environments occur in vascular and pulmonary diseases as well as cancer, which illustrates the broad impact of gene regulation by HIF1A.
Products:
Highly potent and selective HIF-1α inhibitor
| Alternate Names: | Quinomycin A |
| Chemical Name: | N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether |
| Purity: | ≥98% (HPLC) |
Prolyl hydroxylase inhibitor
| Chemical Name: | N-(2-Methoxy-2-oxoacetyl)glycine methyl ester |
| Purity: | ≥97% (HPLC) |
Thioredoxin-1 inhibitor
| Alternate Names: | IV-2 |
| Chemical Name: | 2-[(1-Methylpropyl)dithio]-1H-imidazole |
| Purity: | ≥98% (HPLC) |
HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
| Chemical Name: | N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide |
| Purity: | ≥98% (HPLC) |
Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
| Chemical Name: | N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine |
| Purity: | ≥98% (HPLC) |
HIF α-subunit inhibitor
| Chemical Name: | 2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate |
| Purity: | ≥98% (HPLC) |
Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α
| Alternate Names: | CAY 10585 |
| Chemical Name: | Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]benzoate |
| Purity: | ≥98% (HPLC) |
Inhibitor of VHL; blocks interaction of VHL and HIF-α
| Chemical Name: | (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
