Echinomycin
Tocris Bioscience, part of Bio-Techne | Catalog # 5520
Highly potent and selective HIF-1α inhibitor
Key Product Details
Description
Highly potent and selective HIF-1α inhibitor
Alternative Names
Quinomycin A
Product Description
Echinomycin is a highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB. Inhibits colony formation of cancer stem cells (CSC) with a 100-fold selectivity over normal hematopoietic progenitor cells. Eradicates mouse lymphomas and human AML xenografts by eliminating CSCs.Product Specifications
Molecular Weight
1101.26
Formula
C51H64N12O12S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether
CAS Number
512-64-1
PubChem ID
91826096
InChI Key
AUJXLBOHYWTPFV-LDUXBRJQSA-N
SMILES
O=C(N[C@](C(N[C@H](C(N(C)[C@@](C(SC[C@@](N(C)C([C@H](C)NC4=O)=O)([H])C3=O)SC)([H])C(N(C)[C@@H]([C@@H](C)C)C(OC[C@]([H])4NC(C5=CN=C(C=CC=C6)C6=N5)=O)=O)=O)=O)C)=O)([H])COC([C@H]([C@@H](C)C)N3C)=O)C2=NC1=CC=CC=C1N=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5 |
Preparing Stock Solutions
for Echinomycin
The following data is based on the product molecular weight 1101.26
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 18.16 mL | 90.81 mL | 181.61 mL |
| 0.25 mM | 3.63 mL | 18.16 mL | 36.32 mL |
| 0.5 mM | 1.82 mL | 9.08 mL | 18.16 mL |
| 2.5 mM | 0.36 mL | 1.82 mL | 3.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kwon Physical and functional interactions between Runx2 and HIF-1α induce vascular endothelial growth factor gene expression. J.Cell.Biochem. 2011 PMID: 21793044
- Kong Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005 PMID: 16204079
- Wang Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 2011 PMID: 21474104
Product Specific Notices for Echinomycin
For research use only
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