IOX 2
Tocris Bioscience, part of Bio-Techne | Catalog # 4451
Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
Key Product Details
Description
Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
Product Description
IOX 2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3. Cell permeable.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the IOX 2 probe summary on the SGC website.Product Specifications
Molecular Weight
352.34
Formula
C19H16N2O5
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
CAS Number
931398-72-0
PubChem ID
54685215
InChI Key
CAOSCCRYLYQBES-UHFFFAOYSA-N
SMILES
OC(C1=CC=CC=C1N2CC3=CC=CC=C3)=C(C(NCC(O)=O)=O)C2=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.23 | 100 |
Preparing Stock Solutions
for IOX 2
The following data is based on the product molecular weight 352.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.84 mL | 14.19 mL | 28.38 mL |
| 5 mM | 0.57 mL | 2.84 mL | 5.68 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.84 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Murray Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity. J.Comb.Chem. 2010 PMID: 20666436
Product Specific Notices for IOX 2
For research use only
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