9 results for "HIF-1 alpha/HIF1A Small Molecules and Peptides" in Products
HIF-1 alpha/HIF1A Small Molecules and Peptides
The hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha/HIF1A) is the regulated member of the transcription factor heterodimer HIF-1 alpha/beta. HIF-1 alpha/HIF1A binds to hypoxia-response elements (HREs) in the promoters of many genes involved in the adaptation to an environment of insufficient oxygen or hypoxia. Hypoxic tissue environments occur in vascular and pulmonary diseases as well as cancer, which illustrates the broad impact of gene regulation by HIF1A.
Prolyl hydroxylase inhibitor
SUV39H1 inhibitor
HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
Highly potent and selective HIF-1α inhibitor
Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
Potent HIF-1α inhibitor
Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α
Potent HIF-1α inhibitor
Inhibitor of VHL; blocks interaction of VHL and HIF-α
