GN 44028
Tocris Bioscience, part of Bio-Techne | Catalog # 5655
Potent HIF-1α inhibitor
Product Description
GN 44028 is a potent HIF-1α inhibitor (IC50 = 14 nM). Inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. Cytotoxic to a range of cancer cell types in vitro.Product Specifications
Molecular Weight
305.33
Formula
C18N15N3O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
CAS Number
1421448-26-1
PubChem ID
71625259
InChI Key
CGZKSZVSWAAUHE-UHFFFAOYSA-N
SMILES
C12=CC=CC=C1C3=C(C(NC4=CC(OCCO5)=C5C=C4)=NN3)C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.53 | 100 | |
| Ethanol | 30.53 | 100 |
Preparing Stock Solutions
for GN 44028
The following data is based on the product molecular weight 305.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.28 mL | 16.38 mL | 32.75 mL |
| 5 mM | 0.66 mL | 3.28 mL | 6.55 mL |
| 10 mM | 0.33 mL | 1.64 mL | 3.28 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Minegishi Discovery of indenopyrazoles as a new class of hypoxia inducible factor (HIF)-1 inhibitors. ACS Med.Chem.Lett. 2013 PMID: 24900662
Product Specific Notices for GN 44028
For research use only
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