LW 6

Name: LW 6
Brand: Tocris Bioscience
SKU: 6322

Tocris Bioscience, part of Bio-Techne | Catalog # 6322

COA / SDS

Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α

Key Product Details

Description:	Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α
Alternative Names:	CAY 10585
Chemical Name:	Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.1^3,7]dec-1-ylphenoxy)acetyl]amino]benzoate
Purity:	≥98% (HPLC)
Molecular Weight:	435.51

View Full Technical Details for LW 6

Technical Data
Citations

Biological Activity for LW 6

LW 6 is a malate dehydrogenase-2 (MDH2) inhibitor (IC₅₀ = 6.3 μM). Also inhibits HIF-1α. Prevents accumulation of HIF-1α in Hep3B cells under hypoxic conditions (IC₅₀ = 2.6 μM) with resulting decrease in expression of HIF-1α target genes VEGF and EPO. Inhibits proliferation of activated human T cells ex vivo.

Compound Libraries for LW 6

LW 6 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for LW 6

M. Wt	435.51
Formula	C₂₆H₂₉NO₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	934593-90-5
PubChem ID	16124726
InChi Key	BJRPPNOJYFZSLY-QXRPDJHGSA-N
Smiles	O=C(C1=CC=C(C(NC(COC2=CC=C(C3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3)C=C2)=O)=C1)O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LW 6

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.78	50

Preparing Stock Solutions for LW 6

The following data is based on the product molecular weight 435.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.59 mL	22.96 mL	45.92 mL
2.5 mM	0.92 mL	4.59 mL	9.18 mL
5 mM	0.46 mL	2.30 mL	4.59 mL
25 mM	0.09 mL	0.46 mL	0.92 mL

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References for LW 6

References are publications that support the biological activity of the product.

Lee (Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors. J.Med.Chem. 2007 PMID: 17328532
Ban A novel malate dehydrogenase 2 inhibitor suppresses hypoxia-inducible factor-1 by regulating mitochondrial respiration. PLoS One 2016 PMID: 27611801
Eleftheriadis Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells. Exp.Ther.Med. 2015 PMID: 26640580