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98 results for "GSK-3 alpha/beta" in Products

GSK-3 alpha/beta Products

GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and cancer.

Catalog #: NBP3-51961

Recombinant Monoclonal Antibody

Catalog #: AF1590AFP647
Catalog #: AF1590AFP594
Catalog #: FAB25063AFP647
Catalog #: FAB25063AFP555
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