GSK-3 alpha/beta Products
GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and cancer.
84 results for "GSK-3 alpha/beta" in Products
84 results for "GSK-3 alpha/beta" in Products
GSK-3 alpha/beta Products
GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and cancer.
Highly selective GSK-3 inhibitor; acts as Wnt activator
| Alternate Names: | CHIR99021,CT99021 |
| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| Purity: | ≥98% |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, CyTOF-ready, ICC, ICFlow |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2b Monoclonal Clone #833916 |
| Applications: | WB, ICC |
| Assay Range: | 156 - 10,000 pg/mL |
| Applications: | ELISA |
Recombinant Monoclonal Antibody.
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SY26-05 |
| Applications: | IHC, WB, ICC/IF, IP |
| Reactivity: | Human, Mouse, Rat, Canine, Bovine, +5 More |
| Details: | Mouse IgG2B Monoclonal Clone #1H8 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: GSK-3 alpha/beta Antibody (1H8) [NB110-85523]](https://resources.bio-techne.com/images/products/GSK-3-alpha-beta-Antibody-1H8-Western-Blot-NB110-85523-img0003.jpg "Western Blot: GSK-3 alpha/beta Antibody (1H8) [NB110-85523]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2b Monoclonal Clone #833916 |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2b Monoclonal Clone #833916 |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2b Monoclonal Clone #833916 |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2b Monoclonal Clone #833916 |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2b Monoclonal Clone #833916 |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2b Monoclonal Clone #833916 |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2b Monoclonal Clone #833916 |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2b Monoclonal Clone #833916 |
| Applications: | WB, ICC |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #S08-8G7 |
| Applications: | WB |
![Western Blot: GSK-3 alpha/beta Antibody (S08-8G7) [NBP3-19938]](https://resources.bio-techne.com/images/products/GSK-3-alpha-beta-Antibody-S08-8G7-Western-Blot-NBP3-19938-img0001.jpg "Western Blot: GSK-3 alpha/beta Antibody (S08-8G7) [NBP3-19938]")