TDZD 8 is a selective non-ATP competitive inhibitor of GSK 3β (IC₅₀ = 2 μM); thiadiazolidinone deriviative. Does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. Reduces severity of L-dopa-induced dyskinesia in a Parkinson's disease in vivo model.

Product Specifications

Molecular Weight

222.26

Formula

C₁₀H₁₀N₂O₂S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione

CAS Number

327036-89-5

PubChem ID

4124851

InChI Key

JDSJDASOXWCHPN-UHFFFAOYSA-N

SMILES

CN1SC(N(C1=O)CC2=CC=CC=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	22.23	100
	Ethanol	22.23	100

Preparing Stock Solutions for TDZD 8

The following data is based on the product molecular weight 222.26

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.50 mL	22.50 mL	44.99 mL
5 mM	0.90 mL	4.50 mL	9.00 mL
10 mM	0.45 mL	2.25 mL	4.50 mL
50 mM	0.09 mL	0.45 mL	0.90 mL

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Background References

References are publications that support the biological activity of the product.

Martinez First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J.Med.Chem. 2002 PMID: 11881998
Xie Inhibition of Glycogen Synthase Kinase-3β (GSK-3 beta) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats. Sci.Rep. 2016 PMID: 26997328

TDZD 8

Tocris Bioscience, part of Bio-Techne | Catalog # 6092

Key Product Details

Description

Alternative Names

View all GSK-3 Inhibitors »

Product Description