AR-A 014418
Tocris Bioscience, part of Bio-Techne | Catalog # 3966
Selective GSK-3 inhibitor
Product Description
AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.Licensing Information
Sold with the permission of AstraZeneca UK Ltd.Product Specifications
Molecular Weight
308.31
Formula
C12H12N4O4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
CAS Number
487021-52-3
PubChem ID
448014
InChI Key
YAEMHJKFIIIULI-UHFFFAOYSA-N
SMILES
O=C(NCC2=CC=C(OC)C=C2)NC1=NC=C([N+]([O-])=O)S1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.83 | 100 | |
| Ethanol | 1.54 | 5 |
Preparing Stock Solutions
for AR-A 014418
The following data is based on the product molecular weight 308.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.24 mL | 16.22 mL | 32.43 mL |
| 5 mM | 0.65 mL | 3.24 mL | 6.49 mL |
| 10 mM | 0.32 mL | 1.62 mL | 3.24 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.65 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bhat Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J.Biol.Chem. 2003 PMID: 12928438
- Gould AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int.J.Neuropsychopharmacol. 2004 PMID: 15315719
- Bhat and Budd GSK3β signalling: casting a wide net in Alzheimer's disease. Neurosignals 2002 PMID: 12566926
Product Specific Notices for AR-A 014418
For research use only
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