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Proteome Profiler Human Phospho-Kinase Array Kit
R&D Systems, Inc. a Bio-Techne Brand
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Detection of Human Protein Kinase Phosphorylation in A549 Cell Line. A549 human lung adenocarcinoma cells were either left untreated or exposed to 50 J/m2 of UV light followed by a 24 hour recovery before lysis. |
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Detection of Human Protein Kinase Phosphorylation in Daudi Cell Line. Daudi human B cell lymphoma cells were either left untreated or treated with 500 U/ml recombinant human IFN-alpha 2a (R&D Systems®, Catalog # 11100-1) for 5 minutes. |
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Detection of Human Protein Kinase Phosphorylation in Jurkat Cell Line. Jurkat human acute T cell leukemia cells were either left untreated or treated with 100 ng/mL PMA and 0.5 mM Ionomycin for 20 minutes. |
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Detection of Human Protein Kinase Phosphorylation in MCF-7 Cell Line. MCF-7 human breast cancer cells were either left untreated or treated with 100 ng/mL of recombinant human IGF-1 (R&D Systems®, Catalog # 291-G1) for 1 hour. |
Citations for Proteome Profiler Human Phospho-Kinase Array Kit (355)
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Citations are publications that use Bio-Techne products. Selected citations for Proteome Profiler Human Phospho-Kinase Array Kit include:
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Species: Human
Sample Types: Cell Lysates
E Sar?yar et al. (2023-01-01), EGFR and Lyn inhibition augments regorafenib induced cell death in sorafenib resistant 3D tumor spheroid model Cellular Signalling, 0(0):110608.
PMID: 36693455 -
Species: Human
Sample Types: Cell Lysates
Z Liu et al. (2022-01-01), SLC4A4 promotes prostate cancer progression in vivo and in vitro via AKT-mediated signalling pathway Cancer Cell International, 22(1):127.
PMID: 35305629 -
Species: Mouse
Sample Types: Serum
J Mooz et al. (2022-01-01), ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers Science Advances, 8(11):eabk1538.
PMID: 35302851 -
Species: Human
Sample Types: Cell Culture Supernates
T Braun et al. (2022-01-01), Non-canonical function of AGO2 augments T-cell receptor signaling in T-cell prolymphocytic leukemia Cancer Research, 0(0).
PMID: 35259248 -
Species: Human
Sample Types: Cell Lysates
E Shimada et al. (2022-01-01), Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma British Journal of Cancer, 0(0).
PMID: 35017658 -
Species: Mouse
Sample Types: Cell Lysates
S Bini et al. (2022-01-01), The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway Biomolecules, 12(4).
PMID: 35454174 -
Species: Human
Sample Types: Cell Lysates
EJ Lim et al. (2022-01-01), ICAM-1 promotes cancer progression by regulating SRC activity as an adapter protein in colorectal cancer Cell Death Disease, 2022;13(4):417.
PMID: 35487888 -
Species: Human
Sample Types: Cell Lysates
Y Huang et al. (2022-01-01), Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model Cell Reports, 39(2):110670.
PMID: 35417708 -
Species: Human
Sample Types: Cell Culture Supernates
X Zhang et al. (2022-01-01), DDR1 promotes hepatocellular carcinoma metastasis through recruiting PSD4 to ARF6 Oncogene, 0(0).
PMID: 35140331 -
Species: Human
Sample Types: Cell Lysates
M Kakarla et al. (2022-01-01), Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer Cancers, 14(9).
PMID: 35565468 -
Species: Human
Sample Types: Cell Lysates
M Almutlaq et al. (2022-01-01), Angiotensin II Exaggerates SARS-CoV-2 Specific T-Cell Response in Convalescent Individuals following COVID-19 International Journal of Molecular Sciences, 23(15).
PMID: 35955801 -
Species: Human
Sample Types: Whole Cells
A Jouida et al. (2022-01-01), Exosomes from EGFR-Mutated Adenocarcinoma Induce a Hybrid EMT and MMP9-Dependant Tumor Invasion Cancers, 14(15).
PMID: 35954442 -
Species: Human
Sample Types: Cell Lysates
C Gaiteiro et al. (2022-01-01), Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion Theranostics, 12(7):3150-3177.
PMID: 35547758 -
Species: Human
Sample Types: Cell Lysates
MK Mamidi et al. (2022-01-01), Idelalisib activates AKT via increased recruitment of PI3Kdelta/PI3Kbeta to BCR signalosome while reducing PDK1 in post-therapy CLL cells Leukemia, 0(0).
PMID: 35568768 -
Species: Human
Sample Types: Cell Lysates
JX Lin et al. (2022-01-01), m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer Cell Death Disease, 2022;13(5):463.
PMID: 35568711 -
Species: Human
Sample Types: Cell Lysates
C Zhao et al. (2022-01-01), GSK3beta palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis Oncogenesis, 11(1):28.
PMID: 35606353 -
Species: Human
Sample Types: Cell Lysates
C Alonso-Gon et al. (2022-01-01), Melatonin Modulation of Radiation-Induced Molecular Changes in MCF-7 Human Breast Cancer Cells Biomedicines, 10(5).
PMID: 35625825 -
Species: Mouse
Sample Types: Cell Culture Supernates
W Jiang et al. (2022-01-01), Macrophage SAMSN1 protects against sepsis-induced acute lung injury in mice Redox Biology, 56(0):102432.
PMID: 35981417 -
Species: Human
Sample Types: Cell culture supernate
C Xu et al. (2022-01-01), Tsp2 Facilitates Tumor-associated Fibroblasts Formation and Promotes Tumor Progression in Retroperitoneal Liposarcoma International journal of biological sciences, 18(13):5038-5055.
PMID: 35982904 -
Species: Human
Sample Types: Cell Culture Supernates
C He et al. (2022-01-01), Kayadiol exerted anticancer effects through p53-mediated ferroptosis in NKTCL cells BMC Cancer, 22(1):724.
PMID: 35778693 -
Species: Human
Sample Types: Cell Lysates
F Peglion et al. (2022-01-01), PTEN inhibits AMPK to control collective migration Nature Communications, 13(1):4528.
PMID: 35953476 -
Species: Human
Sample Types: Tissue Lysates
M Flück et al. (2022-01-01), Post-translational dysregulation of glucose uptake during exhaustive cycling exercise in vastus lateralis muscle of healthy homozygous carriers of the ACE deletion allele Frontiers in Physiology, 13(0):933792.
PMID: 36148310 -
Species: Human
Sample Types: Cell Lysates
K Kamat et al. (2022-01-01), Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer British Journal of Cancer, 0(0).
PMID: 35750747 -
Species: Xenograft
Sample Types: Cell Lysates
N Ding et al. (2022-01-01), Peroxiredoxin IV plays a critical role in cancer cell growth and radioresistance through the activation of the Akt/GSK3 signaling pathways The Journal of Biological Chemistry, 0(0):102123.
PMID: 35697073 -
Species: Human
Sample Types: Cell Lysates
CT Stackhouse et al. (2022-01-01), An in vivo model of glioblastoma radiation resistance identifies long non-coding RNAs and targetable kinases JCI Insight, 0(0).
PMID: 35852875 -
Species: Human
Sample Types: Cell Culture Supernates
S Pietrobono et al. (2022-01-01), p38 MAPK-dependent phosphorylation of transcription factor SOX2 promotes an adaptive response to BRAF inhibitors in melanoma cells The Journal of Biological Chemistry, 298(9):102353.
PMID: 35944584 -
Species: Human
Sample Types: Cell Lysates
T Chernova et al. (2022-01-01), Extracellular Vesicles Isolated from Malignant Mesothelioma Cancer-Associated Fibroblasts Induce Pro-Oncogenic Changes in Healthy Mesothelial Cells International Journal of Molecular Sciences, 23(20).
PMID: 36293328 -
Species: Human
Sample Types: Cell Lysates
P Marona et al. (2022-01-01), Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation Cell Death Disease, 2022;13(9):814.
PMID: 36138026 -
Species: Human
Sample Types: Cell Culture Supernates
D Ávila-Gonz et al. (2022-01-01), The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells Elife, 11(0).
PMID: 35815953 -
Species: Human
Sample Types: Cell Lysates
J Ablain et al. (2022-01-01), Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion Nature Genetics, 0(0).
PMID: 36229674 -
Species: Human
Sample Types: Whole Cells
HH Chu et al. (2022-01-01), CCL4 Regulates Eosinophil Activation in Eosinophilic Airway Inflammation International Journal of Molecular Sciences, 23(24).
PMID: 36555793 -
Species: Human
Sample Types: Cell Lysates
H Takahashi et al. (2022-01-01), BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression in type 1 diabetes Science Advances, 8(46):eabq7240.
PMID: 36383663 -
Species: Human
Sample Types: Cell Lysates
MV Barbolina (2022-01-01), Targeting Microtubule-Associated Protein Tau in Chemotherapy-Resistant Models of High-Grade Serous Ovarian Carcinoma Cancers, 14(18).
PMID: 36139693 -
Species: Human
Sample Types: Cell Lysates
R Clemen et al. (2022-01-01), Oxidized Proteins Differentially Affect Maturation and Activation of Human Monocyte-Derived Cells Cells, 11(22).
PMID: 36429087 -
Species: Human
Sample Types: Cell Culture Supernates
H Sevim et al. (2021-01-01), Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells PLoS ONE, 16(6):e0253170.
PMID: 34133426 -
Species: Human
Sample Types: Cell Culture Supernates
K Andelid et al. (2021-01-01), Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis Respiratory Research, 22(1):172.
PMID: 34098956 -
Species: Human
Sample Types: Cell Culture Supernates
MA Chawsheen et al. (2021-01-01), mTOR modulates resistance to gemcitabine in lung cancer in an MTORC2 dependent mechanism Cellular Signalling, 81(0):109934.
PMID: 33545231 -
Species: Human
Sample Types: Cell Lysates
F Benedetti et al. (2021-01-01), Exogenous bacterial DnaK increases protein kinases activity in human cancer cell lines Journal of Translational Medicine, 19(1):60.
PMID: 33563293 -
Species: Human
Sample Types: Cell Culture Supernates
L Gheysen et al. (2021-01-01), New Treatment Strategy Targeting Galectin-1 against Thyroid Cancer Cells, 10(5).
PMID: 34063063 -
Species: Human
Sample Types: Cell Lysates
SI Noor et al. (2021-01-01), Glycosyltransferase POMGNT1 deficiency strengthens N-cadherin-mediated cell-cell adhesion The Journal of Biological Chemistry, 0(0):100433.
PMID: 33610554 -
Species: Human
Sample Types: Cell Lysates
H Yoon et al. (2021-01-01), TGF-&beta1-mediated transition of resident fibroblasts to cancer-associated fibroblasts promotes cancer metastasis in gastrointestinal stromal tumor Oncogenesis, 10(2):13.
PMID: 33568624 -
Species: Human
Sample Types: Cell Lysates
YJ Lai et al. (2021-01-01), Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail American journal of cancer research, 11(5):2278-2290.
PMID: 34094684 -
Species: Human
Sample Types: Cell Lysate
J Wang et al. (2021-01-01), Feedback activation of STAT3 limits the response to PI3K/AKT/mTOR inhibitors in PTEN-deficient cancer cells Oncogenesis, 10(1):8.
PMID: 33431808 -
Species: Human
Sample Types: Cell Lysates
M Mahdal et al. (2021-01-01), New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRbeta Signaling Cancers, 13(14).
PMID: 34298757 -
Species: Human
Sample Types: Cell Lysates
J Xu et al. (2021-01-01), TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer Nature Communications, 12(1):4413.
PMID: 34285210 -
Species: Human
Sample Types: Cell Lysates
V Vorstandle et al. (2021-01-01), The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation Nature Communications, 12(1):6242.
PMID: 34716325 -
Species: Human
Sample Types: Cell Lysates
S Durlanik et al. (2021-01-01), CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1 Scientific Reports, 11(1):14849.
PMID: 34290311 -
Species: Human
Sample Types: Cell Lysates
J Guo et al. (2021-01-01), miR-301a-3p induced by endoplasmic reticulum stress mediates the occurrence and transmission of trastuzumab resistance in HER2-positive gastric cancer Cell Death Disease, 2021;12(7):696.
PMID: 34257270 -
Species: Human
Sample Types: Cell Lysates
P Ebner-Peki et al. (2021-01-01), Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration Theranostics, 11(17):8430-8447.
PMID: 34373751 -
Species: Human
Sample Types: Cell Culture Supernates
F Luo et al. (2021-01-01), Gemcitabine and APG-1252, a novel small molecule inhibitor of BCL-2/BCL-XL, display a synergistic antitumor effect in nasopharyngeal carcinoma through the JAK-2/STAT3/MCL-1 signaling pathway Cell Death Disease, 2021;12(8):772.
PMID: 34354046 -
Species: Human
Sample Types: Cell Culture Supernates
C Yoon et al. (2021-01-01), PIK3R3, part of the regulatory domain of PI3K, is upregulated in sarcoma stem-like cells and promotes invasion, migration, and chemotherapy resistance Cell Death Disease, 2021;12(8):749.
PMID: 34321458 -
Species: Human
Sample Types: Cell Lysates
S Ma et al. (2021-01-01), CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance Cell Reports, 36(7):109549.
PMID: 34407412 -
Species: Human
Sample Types: Cell Lysates
E Demirel et al. (2021-01-01), RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells Cells, 10(7).
PMID: 34359918 -
Species: Human
Sample Types: Cell Lysates
N Zalcman et al. (2021-01-01), Androgen Receptor Activation in Glioblastoma Can Be Achieved by Ligand-Independent Signaling through EGFR-A Potential Therapeutic Target International Journal of Molecular Sciences, 22(20).
PMID: 34681618 -
Species: Human
Sample Types: Cell Lysates
C Stecher et al. (2021-01-01), Protein Phosphatase 1 Regulates Human Cytomegalovirus Protein Translation by Restraining AMPK Signaling Frontiers in Microbiology, 12(0):698603.
PMID: 34335531 -
Species: Human
Sample Types: Cell Culture Supernates
CE Barcus et al. (2021-01-01), Tyrosine kinase independent actions of DDR2 in tumor cells and CAFs influence tumor invasion, migration, and metastasis Journal of Cell Science, 0(0).
PMID: 34477203 -
Species: Human
Sample Types: Cell Lysates
SH Jo et al. (2021-01-01), S100A8/A9 mediate the reprograming of normal mammary epithelial cells induced by dynamic cell-cell interactions with adjacent breast cancer cells Scientific Reports, 11(1):1337.
PMID: 33446797 -
Species: Human
Sample Types: Cell Lysates
A Pandey et al. (2021-01-01), Combinatorial Effect of PLK1 Inhibition with Temozolomide and Radiation in Glioblastoma Cancers, 13(20).
PMID: 34680264 -
Species: Human
Sample Types: Cell Lysates
CY Jiao et al. (2021-01-01), BUB1B promotes extrahepatic cholangiocarcinoma progression via JNK/c-Jun pathways Cell Death Disease, 2021;12(1):63.
PMID: 33431813 -
Species: Human
Sample Types: Tissue Homogenates
A Quintanal- et al. (2021-01-01), Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation Journal of hematology oncology, 2021;14(1):170.
PMID: 34656143 -
Species: Human
Sample Types: Cell Extract
BH Choi et al. (2021-01-01), Identification of Radil as a Ras binding partner and putative activator The Journal of Biological Chemistry, 0(0):100314.
PMID: 33482197 -
Species: Human
Sample Types: Cell Lysates
Y Ounoughene et al. (2021-01-01), SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase Cancers, 13(24).
PMID: 34944965 -
Species: Human
Sample Types: Cell Culture Supernates
Y Cha et al. (2021-01-01), SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes Cell Reports, 37(13):110155.
PMID: 34965411 -
Species: Human
Sample Types: Cell Lysates
I Berestjuk et al. (2021-01-01), Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma Embo Molecular Medicine, 0(0):e11814.
PMID: 34957688 -
Species: Human
Sample Types: Cell Lysates
D Bakhshinya et al. (2021-01-01), Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence Science Advances, 7(50):eabi5568.
PMID: 34878832 -
Species: Human
Sample Types: Cell Lysates
W Shen et al. (2021-01-01), CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3&beta/&beta-catenin/OCT4 axis Theranostics, 11(5):2297-2317.
PMID: 33500726 -
Species: Human
Sample Types: Cell Lysates
Y Cheng et al. (2021-01-01), Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease EBioMedicine, 75(0):103758.
PMID: 34933179 -
Species: Human
Sample Types: Cell Lysates
D Chauss et al. (2021-01-01), Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells Nature Immunology, 0(0).
PMID: 34764490 -
Species: Human
Sample Types: Cell Lysates
CM Borza et al. (2021-01-01), DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3 JCI Insight, 0(0).
PMID: 34941574 -
Species: Human
Sample Types: Cell Lysates
L Yin et al. (2021-01-01), Protein kinase RNA-activated controls mitotic progression and determines paclitaxel chemosensitivity through B-cell lymphoma 2 in ovarian cancer Oncogene, 0(0).
PMID: 34799660 -
Species: Human
Sample Types: Cell Lysates
YZ Mazzu et al. (2021-01-01), Prognostic and therapeutic significance of COP9 signalosome subunit CSN5 in prostate cancer Oncogene, 0(0).
PMID: 34802033 -
Species: Human
Sample Types: Cell Lysates
G Guney Eski et al. (2021-01-01), Therapeutic potential of the PI3K inhibitor LY294002 and PARP inhibitor Talazoparib combination in BRCA-deficient triple negative breast cancer cells Cellular Signalling, 91(0):110229.
PMID: 34958867 -
Species: Human
Sample Types: Cell Culture Supernates
N Stoup et al. (2021-01-01), The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis Cancers, 13(22).
PMID: 34830899 -
Species: Human
Sample Types: Cell Lysates
K Marunaka et al. (2021-01-01), Elevation of Hyaluronan Synthase by Magnesium Supplementation Mediated through the Activation of GSK3 and CREB in Human Keratinocyte-Derived HaCaT Cells International Journal of Molecular Sciences, 23(1).
PMID: 35008494 -
Species: Human
Sample Types: Whole Cells
RS Smith et al. (2021-01-01), Novel patient-derived models of DSRCT enable validation of ERBB signaling as a potential therapeutic vulnerability Disease Models Mechanisms, 2021;0(0).
PMID: 34841430 -
Species: Human
Sample Types: Cell Lysates
MT Khayat et al. (2021-01-01), Insights on Cancer Cell Inhibition, Subcellular Activities, and Kinase Profile of Phenylacetamides Pending 1H-Imidazol-5-One Variants Frontiers in Pharmacology, 12(0):794325.
PMID: 35069208 -
Species: Human
Sample Types: Cell Lysates
HM Ahn et al. (2021-01-01), GPR87 Promotes Metastasis through the AKT-eNOS-NO Axis in Lung Adenocarcinoma Cancers, 14(1).
PMID: 35008182 -
Species: Human
Sample Types: Cell Lysates
ZII Al-Luhaibi et al. (2021-01-01), IL-36alpha and Lipopolysaccharide Cooperatively Induce Autophagy by Triggering Pro-Autophagic Biased Signaling Biomedicines, 9(11).
PMID: 34829770 -
Species: Human
Sample Types: Tissue Homogenates
TW Jones et al. (2021-01-01), Aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes Scientific Reports, 11(1):10785.
PMID: 34031501 -
Species: Human
Sample Types: Cell Lysates
S Hafner et al. (2021-01-01), The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells Frontiers in Pharmacology, 12(0):611657.
PMID: 34025398 -
Species: Human
Sample Types: Cell Lysates
J Kim et al. (2021-01-01), Akt-mediated Ephexin1-Ras interaction promotes oncogenic Ras signaling and colorectal and lung cancer cell proliferation Cell Death Disease, 2021;12(11):1013.
PMID: 34711817 -
Species: Human
Sample Types: Tissue Homogenates
KJ Roberts et al. (2021-01-01), Preclinical development of a bispecific TNFalpha/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease Scientific Reports, 11(1):19422.
PMID: 34593832 -
Species: Human
Sample Types: Whole Cells
P Shahi Thak et al. (2020-01-01), Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling BMC Cancer, 20(1):4.
PMID: 31898540 -
Species: Human
Sample Types: Protein
Q Zhu et al. (2020-01-01), Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3&beta signalling pathway in renal cell carcinoma J Hematol Oncol, 13(1):2.
PMID: 31900208 -
Species: Human
Sample Types: Cell Lysates
J Zhang et al. (2020-01-01), SNCG promotes the progression and metastasis of high-grade serous ovarian cancer via targeting the PI3K/AKT signaling pathway J. Exp. Clin. Cancer Res., 39(1):79.
PMID: 32381034 -
Species: Human
Sample Types: Whole Cell Extracts
VA Nair et al. (2020-01-01), Oncogenic Potential of Bisphenol A and Common Environmental Contaminants in Human Mammary Epithelial Cells Int J Mol Sci, 21(10).
PMID: 32466334 -
Species: Human
Sample Types: Whole Cells
A Douida et al. (2020-01-01), The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells J. Cell. Mol. Med., 0(0).
PMID: 32368861 -
Species: Human
Sample Types: Whole Cells
MH Sheikh et al. (2020-01-01), Immuno-metabolic impact of the multiple sclerosis patients' sera on endothelial cells of the blood-brain barrier J Neuroinflammation, 17(1):153.
PMID: 32386505 -
Species: Human
Sample Types: Cell Lysate
Y Wang et al. (2020-01-01), Circulating Neutrophils Predict Poor Survival for HCC and Promote HCC Progression Through p53 and STAT3 Signaling Pathway J Cancer, 11(13):3736-3744.
PMID: 32328178 -
Species: Human
Sample Types: Cell Culture Supernates
P Tétu et al. (2020-01-01), FGF2 Induces Resistance to Nilotinib through MAPK Pathway Activation in KIT Mutated Melanoma Cancers (Basel), 12(5).
PMID: 32344828 -
Species: Human
Sample Types: Cell Culture Lysates
JMD Grandjean et al. (2020-01-01), Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming Nat. Chem. Biol., 0(0).
PMID: 32690944 -
Species: Human
Sample Types: Cell Lysates
JW Xie et al. (2020-01-01), m6A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling Mol. Cancer, 19(1):114.
PMID: 32650804 -
Species: Human
Sample Types: Whole Cells
M Pruss et al. (2020-01-01), Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma Br. J. Cancer, 0(0).
PMID: 32115576 -
Species: Human
Sample Types: Whole Cells
A Bah et al. (2020-01-01), The Lipid Virulence Factors of Mycobacterium tuberculosis Exert Multilayered Control over Autophagy-Related Pathways in Infected Human Macrophages Cells, 9(3).
PMID: 32182946 -
Species: Human
Sample Types: Cell Lysates
ES Grassi et al. (2020-01-01), Hypoxia-induced release, nuclear translocation, and signaling activity of a DLK1 intracellular fragment in glioma Oncogene, 0(0).
PMID: 32205867 -
Species: Human
Sample Types: Cell Culture Lysates
C Hurtz et al. (2020-01-01), Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL J. Clin. Invest., 0(0).
PMID: 32191635 -
Species: Human
Sample Types: Cell Culture Lysates
R Ronca et al. (2020-01-01), FGF trapping inhibits multiple myeloma growth through c-Myc degradation-induced mitochondrial oxidative stress Cancer Res., 0(0).
PMID: 32094301 -
Species: Mouse
Sample Types: Cell Culture Lysates
LR Kong et al. (2020-01-01), A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma Nat Commun, 11(1):1556.
PMID: 32214092 -
Species: Human
Sample Types: Cell Culture Lysates
K Oono et al. (2020-01-01), Contribution of Pyk2 pathway and reactive oxygen species (ROS) to the anti-cancer effects of eicosapentaenoic acid (EPA) in PC3 prostate cancer cells Lipids Health Dis, 19(1):15.
PMID: 32005121 -
Species: Human
Sample Types: Cell Culture Lysates
IM Bugueno et al. (2020-01-01), Porphyromonas gingivalis triggers the shedding of inflammatory endothelial microvesicles that act as autocrine effectors of endothelial dysfunction Sci Rep, 10(1):1778.
PMID: 32019950 -
Species: Human
Sample Types: Cell Lysates
EA Willmann et al. (2020-01-01), Extracellular signal-regulated kinase 1/2 is required for complement component C1q and fibronectin dependent enhancement of Fc&gamma- receptor mediated phagocytosis in mouse and human cells BMC immunology, 21(1):61.
PMID: 33317446 -
Species: Phoenix dactylifera (Date palm)
Sample Types: Plant Tissue Homogenates
MNK Khattak et al. (2020-01-01), Anticancer activities of selected Emirati Date (Phoenix dactylifera L.) varieties pits in human triple negative breast cancer MDA-MB-231 cells Saudi journal of biological sciences, 27(12):3390-3396.
PMID: 33304147 -
Species: Human
Sample Types: Cell Lysates
CH Lee et al. (2020-01-01), LDOC1 Suppresses Microbe-Induced Production of IL-1&beta in Human Normal and Cancerous Oral Cells through the PI3K/Akt/GSK-3&beta Axis Cancers (Basel), 12(11).
PMID: 33120999 -
Species: Human
Sample Types: Cell Lysates
J Weglage et al. (2020-01-01), Schistosoma mansoni eggs induce Wnt/&beta-catenin signaling and activate the protooncogene c-Jun in human and hamster colon Scientific Reports, 10(1):22373.
PMID: 33361772 -
Species: Human
Sample Types: Cell Lysates
K Wantoch vo et al. (2020-01-01), Insight into Cisplatin-Resistance Signaling of W1 Ovarian Cancer Cells Emerges mTOR and HSP27 as Targets for Sensitization Strategies International Journal of Molecular Sciences, 21(23).
PMID: 33287446 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotN Gao et al. (2020-01-01), The role of TRPV1 ion channels in the suppression of gastric cancer development J Exp Clin Cancer Res, 39(1):206.
PMID: 33008449 -
Species: Human
Sample Types: Serum
B Zhou et al. (2020-01-01), Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling Nat Microbiol, 0(0).
PMID: 33077977 -
Species: Rat
Sample Types: Cell Lysates
A Alghamdi et al. (2020-01-01), The loss of microglia activities facilitates glaucoma progression in association with CYP1B1 gene mutation (p.Gly61Glu) PLoS ONE, 15(11):e0241902.
PMID: 33170892 -
Species: Human
Sample Types: Whole Cells
M Szeliga et al. (2020-01-01), Design, synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as anti-glioblastoma agents targeting the AKT pathway Bioorg Chem, 105(0):104362.
PMID: 33074121 -
Species: Human
Sample Types: Cell Lysates
RP Araldi et al. (2020-01-01), LIMD2 Regulates Key Steps of Metastasis Cascade in Papillary Thyroid Cancer Cells via MAPK Crosstalk Cells, 9(11).
PMID: 33238381 -
Species: Mouse
Sample Types: Cell Lysates
S Ketterer et al. (2020-01-01), Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling Nat Commun, 11(1):5133.
PMID: 33046706 -
Species: Human
Sample Types: Cell Lysates
R Wang et al. (2020-01-01), Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer Nat Commun, 11(1):4607.
PMID: 32929081 -
Species: Human
Sample Types: Whole Cells
T Gruber et al. (2020-01-01), IL-32&gamma potentiates tumor immunity in melanoma JCI Insight, 5(18).
PMID: 32841222 -
Species: Human
Sample Types: Cell Lysates
YY Wang et al. (2020-01-01), Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages Cancers, 12(12).
PMID: 33256011 -
Species: Human
Sample Types: Cell Lysates
M Fuentes-Ba et al. (2020-01-01), Differential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines Cancers, 12(12).
PMID: 33322337 -
Species: Human
Sample Types: Cell Lysates
YH Chen et al. (2020-01-01), EPHA2 feedback activation limits the response to PDEdelta inhibition in KRAS-dependent cancer cells Acta Pharmacol. Sin., 41(2):270-277.
PMID: 31316177 -
Species: Human
Sample Types: Cell Lysates
Q Hao et al. (2020-01-01), Comp34 displays potent preclinical antitumor efficacy in triple-negative breast cancer via inhibition of NUDT3-AS4, a novel oncogenic long noncoding RNA Cell Death Disease, 2020;11(12):1052.
PMID: 33311440 -
Species: Human
Sample Types: Cell Lysates
K Regan-Fend et al. (2020-01-01), Transcriptomics-Based Drug Repurposing Approach Identifies Novel Drugs against Sorafenib-Resistant Hepatocellular Carcinoma Cancers (Basel), 12(10).
PMID: 32977582 -
Species: Human
Sample Types: Cell Lysates
S Schwarz et al. (2020-01-01), Glycosaminoglycans as Tools to Decipher the Platelet Tumor Cell Interaction: A Focus on P-Selectin Molecules, 25(5).
PMID: 32110917 -
Species: Human
Sample Types: Cell Culture Supernates
S Bu et al. (2020-01-01), Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/beta-catenin/SLUG axis Cell Death Dis, 11(8):644.
PMID: 32811805 -
Species: Human
Sample Types: Cell Lysates
X Zhang et al. (2020-01-01), Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration JCI Insight, 5(16).
PMID: 32686657 -
Species: Human
Sample Types: Cell Culture Supernates
HK Kim et al. (2020-01-01), TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation Nat Commun, 11(1):4012.
PMID: 32782388 -
Species: Human
Sample Types: Tissue Homogenates, Whole Tissue
A Reszegi et al. (2020-01-01), The Protective Role of Decorin in Hepatic Metastasis of Colorectal Carcinoma Biomolecules, 10(8).
PMID: 32824864 -
Species: Human
Sample Types: Cell Lysates
SJ Lang et al. (2020-01-01), Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells Int J Mol Sci, 21(11).
PMID: 32521698 -
Species: Human
Sample Types: Cell Culture Supernates, Cell Lysates
S Zhang et al. (2020-01-01), Downregulation of RRM2 Attenuates Retroperitoneal Liposarcoma Progression via the Akt/mTOR/4EBP1 Pathway: Clinical, Biological, and Therapeutic Significance Onco Targets Ther, 13(0):6523-6537.
PMID: 32753891 -
Species: Human
Sample Types: Cell Lysates
F Ferro et al. (2019-01-01), Survival/adaptation of Bone Marrow derived Mesenchymal Stem Cells after long term starvation through selective processes Stem Cells, 0(0).
PMID: 30835892 -
Species: Human
Sample Types: Cell Lysates
T van Montfo et al. (2019-01-01), Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathway EBioMedicine, 0(0).
PMID: 30824386 -
Species: Human
Sample Types: Cell Lysates
L Li et al. (2019-01-01), Signal regulatory protein ? protects podocytes through promoting autophagic activity JCI Insight, 5(0).
PMID: 30888336 -
Species: Human
Sample Types: Cell Lysates
Y Bai et al. (2019-01-01), PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1/JNK signaling pathway EBioMedicine, 0(0).
PMID: 30922965 -
Species: Rat
Sample Types: Tissue Homogenates
L Hummitzsch et al. (2019-01-01), Remote ischemic preconditioning attenuates intestinal mucosal damage: insight from a rat model of ischemia-reperfusion injury J Transl Med, 17(1):136.
PMID: 31036020 -
Species: Human
Sample Types: Cell Lysates
R Kumar et al. (2019-01-01), Growth suppression by dual BRAF(V600E) and NRAS(Q61) oncogene expression is mediated by SPRY4 in melanoma Oncogene, 0(0).
PMID: 30651601 -
Species: Human
Sample Types: Cell Lysates
JH Noh et al. (2019-01-01), Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program Nucleic Acids Res., 0(0).
PMID: 30753671 -
Species: Human
Sample Types: Cell Lysates
M Magni et al. (2019-01-01), Tyrosine kinase inhibition to improve anthracycline-based chemotherapy efficacy in T-cell lymphoma Br. J. Cancer, 0(0).
PMID: 31474759 -
Species: Human
Sample Types: Cell Lysates
JH Yoo et al. (2019-01-01), The small GTPase ARF6 activates PI3K in melanoma to induce a pro-metastatic state Cancer Res., 0(0).
PMID: 31048499 -
Species: Human
Sample Types: Cell Lysates
G Pellizzari et al. (2019-01-01), IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states EBioMedicine, 0(0).
PMID: 30956175 -
Species: Human
Sample Types: Cell Lysates
MJ Jo et al. (2019-01-01), Genipin induces mitochondrial dysfunction and apoptosis via downregulation of Stat3/mcl-1 pathway in gastric cancer BMC Cancer, 19(1):739.
PMID: 31351462 -
Species: Human
Sample Types: Cell Lysates
JX Lin et al. (2019-01-01), UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expres7sion of PDK1 through PI3K/AKT signaling J. Exp. Clin. Cancer Res., 38(1):410.
PMID: 31533855 -
Species: Human
Sample Types: Cell Lysates
DA Ferraro et al. (2019-01-01), Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells BMC Cancer, 19(1):312.
PMID: 30947697 -
Species: Human
Sample Types: Cell Lysates
T Sun et al. (2019-01-01), Multilevel defects in the hematopoietic niche in essential thrombocythemia Haematologica, 0(0).
PMID: 31289202 -
Species: Human
Sample Types: Cell Culture Supernates
JH Kim et al. (2019-01-01), Interleukin-6 mediates resistance to PI3K-pathway-targeted therapy in lymphoma BMC Cancer, 19(1):936.
PMID: 31601188 -
Species: Human
Sample Types: Cell Lysates
MK Jolly et al. (2019-01-01), E-cadherin represses anchorage-independent growth in sarcomas through both signaling and mechanical mechanisms Mol. Cancer Res., 0(0).
PMID: 30862685 -
Species: Human
Sample Types: Cell Lysates
IA Schepetkin et al. (2019-01-01), Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds Molecules, 24(9).
PMID: 31083328 -
Species: Human
H Taniguchi et al. (2019-01-01), AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells Nat Commun, 10(1):259.
PMID: 30651547 -
Species: Human
Sample Types: Cell Lysates
G Martini et al. (2019-01-01), EPHA2 is a predictive biomarker of resistance and a potential therapeutic target for improving anti-epidermal growth factor receptor therapy in colorectal cancer Mol. Cancer Ther., 0(0).
PMID: 30824612 -
Species: Human
Sample Types: Cell Lysates
YC Ko et al. (2019-01-01), Cytarabine-Resistant FLT3-ITD Leukemia Cells are Associated with TP53 Mutation and Multiple Pathway Alterations-Possible Therapeutic Efficacy of Cabozantinib Int J Mol Sci, 20(5).
PMID: 30862120 -
Species: Human
Sample Types: Cell Lysates
S Ashraf et al. (2019-01-01), CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation JCI Insight, 0(0).
PMID: 30721154 -
Species: Human
Sample Types: Cell Lysates
Y Zhao et al. (2019-01-01), MicroRNA-29a activates a multi-component growth and invasion program in glioblastoma J. Exp. Clin. Cancer Res., 38(1):36.
PMID: 30683134 -
Species: Human
Sample Types: Whole Cells
ME Nickol et al. (2019-01-01), Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant Staphylococcus aureus Viruses, 11(2).
PMID: 30699912 -
Species: Mouse
Sample Types: Cell Lysates
C Zalfa et al. (2019-01-01), Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin J. Leukoc. Biol., 0(0).
PMID: 30690783 -
Species: Human
Sample Types: Cell Lysates
H de Boussac et al. (2019-01-01), Kinome expression profiling to target new therapeutic avenues in multiple myeloma Haematologica, 0(0).
PMID: 31289205 -
Species: Human
Sample Types: Cell Lysates
D Neelakanta et al. (2019-01-01), Multifunctional APJ Pathway Promotes Ovarian Cancer Progression and Metastasis Mol. Cancer Res., 0(0).
PMID: 30858172 -
Species: Human
Sample Types: Cell Lysates
J Menéndez-M et al. (2019-01-01), Deciphering the Molecular Basis of Melatonin Protective Effects on Breast Cells Treated with Doxorubicin: TWIST1 a Transcription Factor Involved in EMT and Metastasis, a Novel Target of Melatonin Cancers (Basel), 11(7).
PMID: 31331001 -
Species: Human
Sample Types: Cell Lysates
J Chen et al. (2019-01-01), A functional CRISPR/Cas9 screen identifies kinases that modulate FGFR inhibitor response in gastric cancer Oncogenesis, 8(5):33.
PMID: 31076567 -
Species: Human
Sample Types: Cell Culture Supernates
Z Xiao et al. (2019-01-01), Lung cancer stem cells and their aggressive progeny, controlled by EGFR/MIG6 inverse expression, dictate a novel NSCLC treatment approach Oncotarget, 10(26):2546-2560.
PMID: 31069016 -
Species: Human
Sample Types: Cell Lysates
J Wurm et al. (2019-01-01), Astrogliosis Releases Pro-Oncogenic Chitinase 3-Like 1 Causing MAPK Signaling in Glioblastoma Cancers (Basel), 11(10).
PMID: 31561550 -
Species: Human
Sample Types: Cell Lysates
SP Kennedy et al. (2019-01-01), Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer Breast Cancer Res., 21(1):43.
PMID: 30898150 -
Species: Human
Sample Types: Cell Lysates
R Xu et al. (2019-01-01), CCL2 promotes macrophages-associated chemoresistance via MCPIP1 dual catalytic activities in multiple myeloma Cell Death Dis, 10(10):781.
PMID: 31611552 -
Species: Human
Sample Types: Protein
NL Cook et al. (2019-01-01), CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation BMC Endocr Disord, 19(1):115.
PMID: 31664995 -
Species: Human
Sample Types: Cell Lysates
SA Scarneo et al. (2019-01-01), Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice Arthritis Res. Ther., 21(1):292.
PMID: 31847895 -
Species: Human
Sample Types: Cell Culture Supernates
PH Su et al. (2019-01-01), Paired Box-1 (PAX1) Activates Multiple Phosphatases and Inhibits Kinase Cascades in Cervical Cancer Sci Rep, 9(1):9195.
PMID: 31235851 -
Species: Human
Sample Types: Cell Lysates
AL Potthoff et al. (2019-01-01), Inhibition of Gap Junctions Sensitizes Primary Glioblastoma Cells for Temozolomide Cancers (Basel), 11(6).
PMID: 31226836 -
Species: Human
Sample Types: Cell Lysates
S Jeong et al. (2019-01-01), Cannabidiol Overcomes Oxaliplatin Resistance by Enhancing NOS3- and SOD2-Induced Autophagy in Human Colorectal Cancer Cells Cancers (Basel), 11(6).
PMID: 31195721 -
Species: Human
Sample Types: Cell Lysates
S Offer et al. (2019-01-01), Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration J. Exp. Clin. Cancer Res., 38(1):241.
PMID: 31174567 -
Species: Human
Sample Types: Cell Lysates
MY Gökyildiri et al. (2018-01-01), Targeting CREB-binding protein overrides LPS induced radioresistance in non-small cell lung cancer cell lines Oncotarget, 9(48):28976-28988.
PMID: 29989005 -
Species: Human
Sample Types: Cell Lysates
J Chéret et al. (2018-01-01), Olfactory receptor OR2AT4 regulates human hair growth Nat Commun, 9(1):3624.
PMID: 30228264 -
Species: Human
Sample Types: Cell Lysates
C Li et al. (2018-01-01), Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo Sci Rep, 8(1):10070.
PMID: 29968778 -
Species: Mouse
Sample Types: Cell Lysates
G Xiao et al. (2018-01-01), B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies Cell, 0(0).
PMID: 29551267 -
Species: Mouse
C Hernandez et al. (2018-01-01), HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis J. Clin. Invest., 0(0).
PMID: 29558367 -
Species: Human
Sample Types: Cell Lysates
BM Ku et al. (2018-01-01), Acquired resistance to AZD9291 as an upfront treatment is dependent on ERK signaling in a preclinical model PLoS ONE, 13(4):e0194730.
PMID: 29641535 -
Species: Human
Sample Types: Cell Lysates
U Baumgartne et al. (2018-01-01), miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer Mol. Cancer, 17(1):44.
PMID: 29455644 -
Species: Human
Sample Types: Cell Lysates
Charalambos Kaittanis et al. (2018-01-01), Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors. The Journal of Experimental Medicine, 0(0):1540-9538.
PMID: 29141866 -
Species: Human
Sample Types: Cell Lysates
T Wagner et al. (2018-01-01), Establishment of keratinocyte cell lines from human hair follicles Sci Rep, 8(1):13434.
PMID: 30194332 -
Species: Human
Sample Types: Cell Lysates
L Deng et al. (2018-01-01), NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway Cell Death Dis, 9(12):1143.
PMID: 30446635 -
Species: Human
Sample Types: Cell Lysates
TM Totiger et al. (2018-01-01), Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer Mol. Cancer Ther., 0(0).
PMID: 30404927 -
Species: Human
Sample Types: Cell Lysates
X Gong et al. (2018-01-01), Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms Molecules, 23(4).
PMID: 29662002 -
Species: Human
Sample Types: Cell Lysates
C Klein et al. (2018-01-01), 5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease Acta Neuropathol Commun, 6(1):136.
PMID: 30537985 -
Species: Human
Sample Types: Cell Culture Supernates
M Shimizu et al. (2018-01-01), IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells Oncogene, 0(0).
PMID: 30305725 -
Species: Human
Sample Types: Cell Lysates
K Taniuchi et al. (2018-01-01), BCL7B, a predictor of poor prognosis of pancreatic cancers, promotes cell motility and invasion by influencing CREB signaling Am J Cancer Res, 8(3):387-404.
PMID: 29636996 -
Species: Human
Sample Types: Cell Lysates
MH Kubala et al. (2018-01-01), Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer Cell Rep, 25(8):2177-2191.e7.
PMID: 30463014 -
Species: Human
Sample Types: Cell Lysates
S Redaelli et al. (2018-01-01), Lorlatinib treatment elicits multiple on- and off-target mechanisms of resistance in ALK-driven cancer Cancer Res., 0(0).
PMID: 30322862 -
Species: Human
Sample Types: Cell Lysates
Z Fang et al. (2018-01-01), Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-?/STAT3 Pathway Cell. Physiol. Biochem., 47(5):1751-1768.
PMID: 29953970 -
Species: Human
Sample Types: Whole Cells
A Arenas Cor et al. (2018-01-01), Ruxolitinib in combination with prednisone and nilotinib exhibit synergistic effects in human cells lines and primary cells from myeloproliferative neoplasms Haematologica, 0(0).
PMID: 30545926 -
Species: Human
Sample Types: Cell Lysates
TY Wong et al. (2018-01-01), Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1 J Clin Med, 7(11).
PMID: 30400259 -
Species: Human
Sample Types: Cell Lysates
P Urriola-Mu et al. (2018-01-01), Bisphenol-A and Nonylphenol Induce Apoptosis in Reproductive Tract Cancer Cell Lines by the Activation of ADAM17 Int J Mol Sci, 19(8).
PMID: 30065191 -
Species: Human
Sample Types: Cell Lysates
G Tornillo et al. (2018-01-01), Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells Cell Rep, 25(13):3674-3692.e10.
PMID: 30590041 -
Species: Human
Sample Types: Cell Lysates
Y Jiang et al. (2018-01-01), Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression Nat Commun, 9(1):3619.
PMID: 30190462 -
Species: Human
Sample Types: Cell Lysates
S Heavey et al. (2018-01-01), Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines Sci Rep, 8(1):1652.
PMID: 29374181 -
Species: Human
Sample Types: Cell Lysates
E Narvi et al. (2018-01-01), Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin Sci Rep, 8(1):16579.
PMID: 30410004 -
Species: Mouse
Sample Types: Cell Lysates
J Kim et al. (2018-01-01), ?-arrestin 1 regulates ?2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility Skelet Muscle, 8(1):39.
PMID: 30591079 -
Species: Human
Sample Types: Cell Lysates
X Zhang et al. (2018-01-01), YM155 decreases radiation-induced invasion and reverses epithelial-mesenchymal transition by targeting STAT3 in glioblastoma J Transl Med, 16(1):79.
PMID: 29571296 -
Species: Human
Sample Types: Cell Lysates
F Pareja et al. (2018-01-01), Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors Nat Commun, 9(1):3533.
PMID: 30166553 -
Species: Human
Sample Types: Cell Lysates
S Huh et al. (2018-01-01), Suppression of the ERK-SRF axis facilitates somatic cell reprogramming Exp. Mol. Med., 50(2):e448.
PMID: 29472703 -
Species: Human
Sample Types: Cell Lysates
PD Fan et al. (2018-01-01), YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics Proc. Natl. Acad. Sci. U.S.A., 115(26):E6030-E6038.
PMID: 29875142 -
Species: Human
Sample Types: Cell Lysates
Y Zhang et al. (2018-01-01), Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT Cell. Physiol. Biochem., 50(2):612-628.
PMID: 30308494 -
Species: Human
Sample Types: Tissue Homogenates
CS Gonçalves et al. (2018-01-01), WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma Theranostics, 8(17):4805-4823.
PMID: 30279739 -
Species: Human
Sample Types: Cell Lysates
BH Choi et al. (2018-01-01), K-Ras lysine-42 is crucial for its signaling, cell migration and invasion J. Biol. Chem., 0(0).
PMID: 30228186 -
Species: Human
Sample Types: Cell Lysates
V Pandey et al. (2018-01-01), Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation Proc. Natl. Acad. Sci. U.S.A., 0(0).
PMID: 30309962 -
Species: Human
Sample Types: Cell Lysates
V Vishwakarm et al. (2018-01-01), Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds Sci Rep, 8(1):12163.
PMID: 30111862 -
Species: Human
Sample Types: Cell Lysates
W Li et al. (2018-01-01), CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1? axis to inhibit gastric tumorigenesis Oncogene, 0(0).
PMID: 30054562 -
Species: Human
Sample Types: Tissue Homogenates
W Chen et al. (2018-01-01), WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling Oncotarget, 9(43):27197-27219.
PMID: 29930759 -
Species: Human
Sample Types: Cell Lysates
JM Santiago-O et al. (2018-01-01), Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy Oncotarget, 9(2):1602-1616.
PMID: 29416717 -
Species: Human
Sample Types: Cell Lysates
X Wang et al. (2018-01-01), The secretome engages STAT3 to favor a cytokine-rich microenvironment in mediating acquired resistance to FGFR inhibitors Mol. Cancer Ther., 0(0).
PMID: 30523050 -
Species: Human
Sample Types: Protein
J Heger et al. (2018-01-01), JDP2 overexpression provokes cardiac dysfunction in mice Sci Rep, 8(1):7647.
PMID: 29769710 -
Species: Human
Sample Types: Cell Lysates
W Miao et al. (2018-01-01), Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist Sci Rep, 8(1):16492.
PMID: 30405161 -
Species: Human
Sample Types: Cell Lysates
I Yeo et al. (2018-01-01), Low-molecular weight keratins with anti-skin aging activity produced by anaerobic digestion of poultry feathers with Fervidobacterium islandicum AW-1 J. Biotechnol., 0(0).
PMID: 29438785 -
Species: Human
Sample Types: Cell Lysates
K Taniuchi et al. (2018-01-01), WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4 Cancer Med, 0(0).
PMID: 30353690 -
Species: Human
Sample Types: Cell Lysates
E Golec et al. (2018-01-01), The Noncoding RNA nc886 Regulates PKR Signaling and Cytokine Production in Human Cells J. Immunol., 0(0).
PMID: 30518569 -
Species: Human
Sample Types: Cell Lysates
P Kuppusamy et al. (2017-01-01), Concomitant activation of ETS-like transcription factor-1 and Death Receptor-5 via extracellular signal-regulated kinase in withaferin A-mediated inhibition of hepatocarcinogenesis in mice Sci Rep, 7(1):17943.
PMID: 29263422 -
Species: Human
Sample Types: Cell Lysates
H Lee et al. (2017-01-01), Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades Int J Mol Sci, 18(5).
PMID: 28534824 -
Species: Human
Sample Types: Cell Lysates
HJ Lee et al. (2017-01-01), Ras-MEK Signaling Mediates a Critical Chk1-dependent DNA Damage Response in Cancer Cells Mol. Cancer Ther, 0(0).
PMID: 28138032 -
Species: Human
Sample Types: Cell Lysates
M Riera-Borr et al. (2017-01-01), Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation J. Immunol., 0(0).
PMID: 29061766 -
Species: Human
Sample Types: Cell Lysates
D Mahadevan et al. (2017-01-01), Disruption of Aneuploidy and Senescence induced by Aurora inhibition promotes intrinsic Apoptosis in double hit or double expressor Diffuse Large B-cell Lymphomas Mol. Cancer Ther., 0(0).
PMID: 28615297 -
Species: Human
Sample Types: Cell Lysates
S Álvarez-Te et al. (2017-01-01), Dysregulation of Mir-196b in Head and Neck Cancers Leads to Pleiotropic Effects in the Tumor Cells and Surrounding Stromal Fibroblasts Sci Rep, 7(1):17785.
PMID: 29259267 -
Species: Human
Sample Types: Tissue Homogenates
EJ Wladis et al. (2017-01-01), Activation of p38 and Erk Mitogen-Activated Protein Kinases Signaling in Ocular Rosacea Invest. Ophthalmol. Vis. Sci, 58(2):843-848.
PMID: 28170535 -
Species: Human
Sample Types: Cell Lysates
FR Teixeira et al. (2017-01-01), FBXO25 regulates MAPK signaling pathway through inhibition of ERK1/2 phosphorylation Arch. Biochem. Biophys., 0(0).
PMID: 28389297 -
Species: Human
Sample Types: Cell Lysates
S Chen et al. (2017-01-01), Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell PLoS ONE, 12(5):e0176501.
PMID: 28467448 -
Species: Human
Sample Types: Cell Lysates
S Janczar et al. (2017-01-01), WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response Cell Death Dis, 8(7):e2955.
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PC Buchanan et al. (2017-01-01), Ectodomain Shedding of the Cell Adhesion Molecule Nectin-4 in Ovarian Cancer is Mediated by ADAM10 and ADAM17 J. Biol. Chem, 0(0).
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Species: Human
Sample Types: Cell Lysates
Z Zhou et al. (2017-01-01), The HIV-1 viral synapse signals human foreskin keratinocytes to secrete thymic stromal lymphopoietin facilitating HIV-1 foreskin entry Mucosal Immunol, 0(0).
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C Ríos-Luci et al. (2017-01-01), Resistance to the antibody-drug conjugate T-DM1 is based in a reduction in lysosomal proteolytic activity Cancer Res., 0(0).
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F Colomb et al. (2017-01-01), Galectin-3 interacts with the cell surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells J. Biol. Chem., 0(0).
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Species: Human
Sample Types: Cell Lysates
A Cavazzoni et al. (2017-01-01), Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN Oncotarget, 0(0).
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SA Nadeau et al. (2017-01-01), Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene J. Biol. Chem, 292(9):3666-3682.
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Sample Types: Cell Lysates
II Kuan et al. (2017-01-01), EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2� Sci Rep, 7(0):41852.
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Y Mo et al. (2017-01-01), Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma Tumour Biol, 39(2):1010428317690.
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JR Ribeiro et al. (2017-01-01), Human Epididymis Protein 4 Promotes Events Associated with Metastatic Ovarian CancerviaRegulation of the Extracelluar Matrix Front Oncol, 7(0):332.
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CH Chang et al. (2017-01-01), Secreted Protein Acidic and Rich in Cysteine (SPARC) Enhances Cell Proliferation, Migration, and Epithelial Mesenchymal Transition, and SPARC Expression is Associated with Tumor Grade in Head and Neck Cancer Int J Mol Sci, 18(7).
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MV Carriero et al. (2017-01-01), Retro-inverso Urokinase Receptor Antagonists for the Treatment of Metastatic Sarcomas Sci Rep, 7(1):1312.
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Benjamin Y Owusu et al. (2017-01-01), Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation. Oncotarget, 0(0):1949-2553.
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D Wang et al. (2017-01-01), Protein C receptor stimulates multiple signaling pathways in breast cancer cells J. Biol. Chem., 0(0).
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K Kalyvianak et al. (2017-01-01), Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer Sci Rep, 7(0):44418.
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TO Cri?an et al. (2017-01-01), Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway Proc. Natl. Acad. Sci. U.S.A., 0(0).
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S Keller et al. (2017-01-01), Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis BMC Cancer, 17(1):845.
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M Tsuboi et al. (2017-01-01), The Transcription Factor HOXB7 Regulates ERK Kinase Activity and Thereby Stimulates the Motility and Invasiveness of Pancreatic Cancer Cells J. Biol. Chem., 0(0).
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Banko Z et al. (2017-01-01), Induction and Differentiation of IL-10-Producing Regulatory B Cells from Healthy Blood Donors and Rheumatoid Arthritis Patients. J Immunol, 198(4):1512-1520.
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K Shien et al. (2017-01-01), JAK1/STAT3 activation through a proinflammatory cytokine pathway leads to resistance to molecularly targeted therapy in non-small cell lung cancer Mol. Cancer Ther., 0(0).
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S Curcic et al. (2017-01-01), Secretory phospholipase A2 modified HDL rapidly and potently suppresses platelet activation Sci Rep, 7(1):8030.
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N Sahu et al. (2017-01-01), Co-targeting of MEK and PDGFR/STAT3 pathways to treat pancreatic ductal adenocar Mol. Cancer Ther., 0(0).
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M Mustapic et al. (2017-01-01), Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes Front Neurosci, 11(0):278.
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K Boengler et al. (2017-01-01), The gap junction modifier ZP1609 decreases cardiomyocyte hypercontracture following ischemia/reperfusion independent from mitochondrial connexin 43 Br. J. Pharmacol., 0(0).
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P Yang et al. (2017-01-01), Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension Circulation, 135(12):1160-1173.
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GM Pio et al. (2017-01-01), Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells PLoS ONE, 12(5):e0177640.
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(2016-01-01), Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance Acta Pharmacol. Sin., 0(0).
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Raymond B Birge (2016-01-01), Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase Cell Commun. Signal, 14(1):19.
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L Bénard et al. (2016-01-01), Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling Circulation, 133(15):1458-71; disc.
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Nicola M Heller (2016-01-01), The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2 J. Biol. Chem., 291(48):24922-24930.
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SH Ahn et al. (2016-01-01), Necrotic cells influence migration and invasion of glioblastoma via NF-?B/AP-1-mediated IL-8 regulation Sci Rep, 6(0):24552.
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Nader Alaridah (2016-01-01), Mycobacteria Manipulate G-Protein-Coupled Receptors to Increase Mucosal Rac1 Expression in the Lungs J Innate Immun, 0(0).
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(2016-01-01), Metabolism regulates cellular functions of bone marrow-derived cells used for cardiac therapy Stem Cells, 0(0).
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(2016-01-01), Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells J Cancer, 7(13):1824-1832.
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(2016-01-01), Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models Oncotarget, 7(26):40531-40545.
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Benjamin Kalbe (2016-01-01), Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line Eur. J. Cell Biol, 0(0).
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(2016-01-01), Murine Polyomavirus Cell Surface Receptors Activate Distinct Signaling Pathways Required for Infection MBio, 7(6).
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Astrid Escudero-E et al. (2016-01-01), Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer. Oncotarget, 0(0):1949-2553.
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(2016-01-01), New insights into the Shwachman-Diamond Syndrome-related haematological disorder: hyper-activation of mTOR and STAT3 in leukocytes Sci Rep, 6(0):33165.
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(2016-01-01), Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism Proc Natl Acad Sci USA, 0(0).
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(2016-01-01), Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18 Sci Rep, 6(0):32255.
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Purushothaman A et al. (2016-01-01), Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions. J Biol Chem, 291(4):1652-63.
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Skolekova S et al. (2016-01-01), Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells. Cell Commun Signal, 14(1):4.
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Yuexi Gu (2016-01-01), BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine Sci Rep, 6(0):28217.
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Aki Tanouchi (2016-01-01), CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells J. Exp. Clin. Cancer Res, 35(1):190.
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(2016-01-01), CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells Oncogene, 0(0).
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(2016-01-01), Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer Oncotarget, 0(0).
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C Raimondi et al. (2016-01-01), A Small Molecule Inhibitor of PDK1/PLC?1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion Sci Rep, 6(0):26142.
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(2016-01-01), Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells Sci Rep, 6(0):33132.
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Zhao D et al. (2015-01-01), Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation. Oncogene, 34(43):5447-59.
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Eggink L et al. (2015-01-01), A Peptide Mimetic of 5-Acetylneuraminic Acid-Galactose Binds with High Avidity to Siglecs and NKG2D. PLoS ONE, 10(6):e0130532.
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Atefi M et al. (2015-01-01), Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma. Mol Cancer, 14(0):27.
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Chang B et al. (2015-01-01), YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway. J Hematol Oncol, 8(0):39.
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Sento S et al. (2015-01-01), Application of a Persistent Heparin Treatment Inhibits the Malignant Potential of Oral Squamous Carcinoma Cells Induced by Tumor Cell-Derived Exosomes. PLoS ONE, 11(2):e0148454.
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Hansen F et al. (2015-01-01), The Thrombin-Derived Host Defense Peptide GKY25 Inhibits Endotoxin-Induced Responses through Interactions with Lipopolysaccharide and Macrophages/Monocytes. J Immunol, 194(11):5397-406.
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Bajpe et al. (2015-01-01), A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity. Oncogene, 34(4):531-6.
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Singh A et al. (2015-01-01), Targeted inhibition of MEK1 by cobimetinib leads to differentiation and apoptosis in neuroblastoma cells. J Exp Clin Cancer Res, 34(0):104.
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Cho Y et al. (2015-01-01), Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5promotes angiogenesis and vasorelaxation. J Biol Chem, 290(1):467-77.
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Yamada T et al. (2015-01-01), Akt Kinase-Interacting Protein 1 Signals through CREB to Drive Diffuse Malignant Mesothelioma. Cancer Res, 75(19):4188-97.
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Paggetti J et al. (2015-01-01), Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts. Blood, 126(9):1106-17.
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Mailly L et al. (2015-01-01), Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody. Nat Biotechnol, 33(5):549-54.
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Bruneau S et al. (2015-01-01), Loss of DGKepsilon induces endothelial cell activation and death independently of complement activation. Blood, 125(6):1038-46.
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Laukkanen et al. (2015-01-01), Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI. PLoS ONE, 10(3):e0121441.
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Man J et al. (2015-01-01), Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling. Cancer Res, 75(8):1760-9.
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Iida et al. (2014-01-01), Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy. Mol Cancer, 13(0):242.
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Kim et al. (2014-01-01), The molecular mechanism underlying the proliferating and preconditioning effect of vitamin C on adipose-derived stem cells. Stem Cells Dev, 23(12):1364-76.
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Lutay N et al. (2014-01-01), Mycobacteria bypass mucosal NF-kB signalling to induce an epithelial anti-inflammatory IL-22 and IL-10 response. PLoS ONE, 9(1):e86466.
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Huck et al. (2014-01-01), Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation. J Biol Chem, 289(6):3138-47.
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Yang et al. (2014-01-01), Histamine contributes to tissue remodeling via periostin expression. J Invest Dermatol, 134(8):2105-13.
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Polajeva J et al. (2014-01-01), Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner. Mol Oncol, 8(1):50-8.
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Ranayhossaini D et al. (2014-01-01), EGF potentiation of VEGF production is cell density dependent in H292 EGFR wild type NSCLC cell line. Int J Mol Sci, 15(10):17686-704.
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Kampen et al. (2014-01-01), Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML. Leukemia, 28(3):589-99.
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Ray et al. (2014-01-01), Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia. Oncogene, 33(7):823-31.
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Marra P et al. (2014-01-01), IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers. Cancer Res, 74(17):4908-21.
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Gu et al. (2014-01-01), Soft matrix is a natural stimulator for cellular invasiveness. Mol Biol Cell, 25(4):457-69.
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Nagalingam A et al. (2014-01-01), Mechanistic elucidation of the antitumor properties of withaferin a in breast cancer. Cancer Res, 74(9):2617-29.
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Large M et al. (2014-01-01), The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. , 0(0).
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Li et al. (2014-01-01), Sensitizing the therapeutic efficacy of taxol with shikonin in human breast cancer cells. PLoS ONE, 9(4):e94079.
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Song W et al. (2014-01-01), JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer. Cancer Res, 74(9):2444-54.
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Lapeire L et al. (2014-01-01), Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling. Cancer Res, 74(23):6806-19.
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Speakman C et al. (2014-01-01), Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naive to primed cell transition. Stem Cells, 32(10):2605-15.
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Sinkevicius et al. (2014-01-01), Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. Proc Natl Acad Sci U S A, 111(28):10299-304.
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Virtanen S et al. (2014-01-01), Adenosine inhibits tumor cell invasion via receptor-independent mechanisms. Mol Cancer Res, 12(12):1863-74.
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Raimondi C et al. (2014-01-01), Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. J Exp Med, 211(6):1167-83.
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Wang L et al. (2014-01-01), Concomitant induction of apoptosis and autophagy by prostate apoptosis response-4 in hypopharyngeal carcinoma cells. Am J Pathol, 184(2):418-30.
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Jokela T et al. (2014-01-01), Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes. J Biol Chem, 289(26):18569-81.
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Victoni T et al. (2014-01-01), Roflumilast N-oxide prevents cytokine secretion induced by cigarette smoke combined with LPS through JAK/STAT and ERK1/2 inhibition in airway epithelial cells. PLoS ONE, 9(1):e85243.
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Naspi A et al. (2014-01-01), Insulin-like-growth-factor-binding-protein-3 (IGFBP-3) contrasts melanoma progression in vitro and in vivo. PLoS ONE, 9(6):e98641.
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Golubkov V et al. (2014-01-01), Downstream signaling and genome-wide regulatory effects of PTK7 pseudokinase and its proteolytic fragments in cancer cells. Cell Commun Signal, 12(0):15.
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Spary L et al. (2014-01-01), Enhancement of T cell responses as a result of synergy between lower doses of radiation and T cell stimulation. J Immunol, 192(7):3101-10.
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Tseng P et al. (2014-01-01), An increase in integrin-linked kinase non-canonically confers NF- inverted question markB-mediated growth advantages to gastric cancer cells by activating ERK1/2. Cell Commun Signal, 12(1):69.
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Lin Z et al. (2014-01-01), Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer. PLoS ONE, 9(1):e85296.
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Lee E et al. (2014-01-01), Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis. Nat Commun, 5(0):4715.
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Liu K et al. (2013-01-01), Sunlight UV-induced skin cancer relies upon activation of the p38alpha signaling pathway. Cancer Res, 73(7):2181-8.
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Davies et al. (2013-01-01), Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer. PLoS ONE, 8(12):e82236.
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Shimizu A et al. (2013-01-01), Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein. J Biol Chem, 288(4):2210-22.
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Szalmas A et al. (2013-01-01), Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein. Virol J, 10(0):79.
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Weidenaar A et al. (2013-01-01), Impaired long-term expansion and self-renewal potential of pediatric acute myeloid leukemia-initiating cells by PTK787/ZK 222584. Mol Cancer Res, 11(4):339-48.
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Mir et al. (2013-01-01), Progesterone receptor membrane component 1/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy. Autophagy, 9(10):1566-78.
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Lekawanvijit S et al. (2013-01-01), The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction. PLoS ONE, 8(12):e83687.
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Drake J et al. (2013-01-01), Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. Proc Natl Acad Sci U S A, 110(49):E4762-9.
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Species: Human
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Haas D et al. (2013-01-01), The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells. PLoS Pathog, 9(11):e1003737.
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Dreses-Werringloer U et al. (2013-01-01), CALHM1 controls the Ca(2)(+)-dependent MEK, ERK, RSK and MSK signaling cascade in neurons. J Cell Sci, 126(0):1199-206.
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Stegeman H et al. (2013-01-01), Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines. Mol Cancer, 12(1):133.
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Species: Human
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(2012-01-01), Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. EMBO J., 31(17):3513-23.
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Olszewski U et al. (2012-01-01), Alterations of phosphoproteins in NCI-H526 small cell lung cancer cells involved in cytotoxicity of cisplatin and titanocene Y. Neoplasia, 14(9):813-22.
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Species: Human
Sample Types: Cell Lysates
Dumitru CA et al. (2012-01-01), A novel p38-MAPK signaling axis modulates neutrophil biology in head and neck cancer. J. Leukoc. Biol., 91(4):591-8.
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Joshi et al. (2012-01-01), Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy. PLoS ONE, 7(10):e44372.
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(2012-01-01), Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia. BMC Cancer, 12(0):431.
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Species: Human
Sample Types: Cell Lysates
Deharvengt S et al. (2012-01-01), Concomitant targeting of EGF receptor, tgf-Beta and SRC points to a novel therapeutic approach in pancreatic cancer. PLoS ONE, 7(6):e39684.
PMID: 22761868 -
Species: Human
Sample Types: Cell Lysates
Cheng W et al. (2012-01-01), Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17ss-estradiol-BSA. PLoS ONE, 7(9):e45529.
PMID: 23029074 -
Species: Human
Sample Types: Cell Lysates
Shih YR et al. (2011-01-01), Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells. J. Bone Miner. Res., 26(4):730-8.
PMID: 20939067 -
Species: Human
Sample Types: Cell Lysates
Ge Y et al. (2011-01-01), Proteome profiling reveals potential toxicity and detoxification pathways following exposure of BEAS-2B cells to engineered nanoparticle titanium dioxide. Proteomics, 11(12):2406-22.
PMID: 21595037 -
Species: Human
Sample Types: Cell Lysates
Li A et al. (2011-01-01), Overexpression of CXCL5 is associated with poor survival in patients with pancreatic cancer. Am. J. Pathol., 178(3):1340-9.
PMID: 21356384 -
Species: Human
Sample Types: Cell Lysates
Martins AS et al. (2011-01-01), IGF1R Signaling in Ewing Sarcoma Is Shaped by Clathrin-/Caveolin-Dependent Endocytosis. PLoS ONE, 6(5):e19846.
PMID: 21611203 -
Species: Human
Sample Types: Cell Lysates
Singhal G et al. (2011-01-01), DNA triplex-mediated inhibition of MET leads to cell death and tumor regression in hepatoma. Cancer Gene Ther., 18(7):520-30.
PMID: 21660063 -
Species: Human
Sample Types: Cell Lysates
Vingtdeux V et al. (2011-01-01), Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-beta peptide degradation. FASEB J., 25(1):219-31.
PMID: 20852062 -
Species: Human
Sample Types: Cell Lysates
Maddigan A et al. (2011-01-01), EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes. J. Immunol., 187(11):5983-94.
PMID: 22039307 -
Species: Human
Sample Types: Tissue Homogenates
Coeffier M et al. (2011-01-01), Influence of leucine on protein metabolism, phosphokinase expression, and cell proliferation in human duodenum1,3. Am. J. Clin. Nutr., 93(6):1255-62.
PMID: 21508089 -
Species: Human
Sample Types: Cell Lysates
Chandarlapaty et al. (2011-01-01), AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. Cancer Cell, 19(1):58-71.
PMID: 21215704 -
Species: Rat
Sample Types: Tissue Homogenates
Li J et al. (2011-01-01), Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways. Cancer Prev Res (Phila), 4(8):1190-7.
PMID: 21791570 -
Species: Human
Sample Types: Cell Lysates
Wei Q et al. (2011-01-01), Sulfiredoxin-Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling. Proc. Natl. Acad. Sci. U.S.A., 108(17):7004-9.
PMID: 21487000 -
Species: Human
Sample Types: Cell Lysates
Dunn EF et al. (2011-01-01), Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab. Oncogene, 30(5):561-74.
PMID: 20956938 -
Species: Human
Sample Types: Cell Lysates
Malik SA et al. (2011-01-01), BH3 mimetics activate multiple pro-autophagic pathways. Oncogene, 30(37):3918-29.
PMID: 21460857 -
Species: Human
Sample Types: Tissue Homogenates
Guo T et al. (2011-01-01), Global molecular dysfunctions in gastric cancer revealed by an integrated analysis of the phosphoproteome and transcriptome. Cell. Mol. Life Sci., 68(11):1983-2002.
PMID: 20953656 -
Species: Human
Sample Types: Tissue Homogenates
Roorda BD et al. (2010-01-01), VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms. Eur. J. Cancer, 46(5):974-82.
PMID: 20064707 -
Species: Human
Sample Types: Cell Lysates
Tomlinson DC et al. (2010-01-01), Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer. Am. J. Pathol., 177(5):2379-86.
PMID: 20889570 -
Species: Human
Sample Types: Cell Lysates
Xiao K et al. (2010-01-01), Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc. Natl. Acad. Sci. U.S.A., 107(34):15299-304.
PMID: 20686112 -
Species: Mouse
Sample Types: Tissue Homogenates
Chen PC et al. (2010-01-01), Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome-associated Sos1 mutation. J. Clin. Invest., 120(12):4353-65.
PMID: 21041952 -
Species: Human
Sample Types: Cell Lysates
Vingtdeux V et al. (2010-01-01), AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J. Biol. Chem., 285(12):9100-13.
PMID: 20080969 -
Species: Human
Sample Types: Cell Lysates
Zhang H et al. (2010-01-01), Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation. Oncogene, 29(17):2517-27.
PMID: 20154728 -
Species: Human
Sample Types: Tissue Homogenates
Dewaele B et al. (2010-01-01), Coactivated platelet-derived growth factor receptor alpha and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma. Cancer Res., 70(18):7304-14.
PMID: 20685895 -
Species: Human
Sample Types: Cell Lysates
Fritz V et al. (2010-01-01), Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol. Cancer Ther., 9(0):1740-54.
PMID: 20530718 -
Species: Human
Sample Types: Cell Lysates
Carretero J et al. (2010-01-01), Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Cancer Cell, 17(0):547-59.
PMID: 20541700 -
Species: Human
Sample Types: Cell Lysates
Smith NJ et al. (2009-01-01), The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1. J. Biol. Chem., 284(26):17527-39.
PMID: 19398560 -
Species: Mouse
Sample Types: Cell Lysates
Couty JP et al. (2009-01-01), Kaposi's sarcoma-associated herpesvirus-G protein-coupled receptor-expressing endothelial cells exhibit reduced migration and stimulated chemotaxis by chemokine inverse agonists. J. Pharmacol. Exp. Ther., 329(3):1142-7.
PMID: 19258523 -
Species: Human
Sample Types: Cell Lysates
Cailleteau C et al. (2009-01-01), A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation. J. Cell. Biochem., 107(4):785-96.
PMID: 19415684 -
Species: Human
Sample Types: Cell Lysates
Barquilla A et al. (), Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation. Mol Biol Cel27(17):2757-70.
PMID: 27385333 -
Species: Human
Sample Types: Cell Lysates
Wculek S et al. (), Neutrophils support lung colonization of metastasis-initiating breast cancer cells. Natur528(7582):413-7.
PMID: 26649828
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Customer Reviews for Proteome Profiler Human Phospho-Kinase Array Kit (10)
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Verified Customer | Posted 04/24/2023
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Verified Customer | Posted 08/02/2022Used human lymphoma samples! Worked fine!
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Verified Customer | Posted 08/02/2022Used this kit with mouse lymphoma cell lines and it worked!
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Verified Customer | Posted 09/16/2021
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Verified Customer | Posted 07/15/2021
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Verified Customer | Posted 03/21/2021
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Verified Customer | Posted 01/27/2021
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Verified Customer | Posted 11/06/2020
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Verified Customer | Posted 03/18/2020Some of the antibodies lack sensitivity. Independent comprobation using the exact same protocol (lysis buffer, etc) and conventional WB rendered higher activation than the kit's
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Verified Customer | Posted 01/21/2020
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FAQs for Proteome Profiler Human Phospho-Kinase Array Kit
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Why are there 8 membranes provided in ARY003C?
ARY003C contains 8 membranes because it is divided into parts A and B with 4 membranes each. Both parts are spotted with different antibodies to avoid interference and cross reactivity as well as maximize sensitivity. Parts A and B each contain 39 different capture antibodies printed in duplicate and should be used together for optimal analysis efficiency. A total of four samples can be run with this kit.
