GLP-1R: Small Molecules and Peptides
GLP-1 R (Glucagon-like Peptide 1 Receptor) is a class B, G protein-linked, seven transmembrane domain protein that is expressed in pancreas, lung, heart, kidney, hypothalamus, and stomach. It is a receptor for Glucagon-like Peptide, a regulator of insulin secretion by pancreatic beta cells. Drugs that target GLP-1 R are of great interest for diabetes related research. Known agonists for GLP-1 R include GLP-1, Boc5, and Cpd1. Following experiments in mouse models, GLP-1 R agonists may also useful in the treatment of acute myocardial infarction.
11 results for "GLP-1R Small Molecules and Peptides" in Products
11 results for "GLP-1R Small Molecules and Peptides" in Products
GLP-1R: Small Molecules and Peptides
GLP-1 R (Glucagon-like Peptide 1 Receptor) is a class B, G protein-linked, seven transmembrane domain protein that is expressed in pancreas, lung, heart, kidney, hypothalamus, and stomach. It is a receptor for Glucagon-like Peptide, a regulator of insulin secretion by pancreatic beta cells. Drugs that target GLP-1 R are of great interest for diabetes related research. Known agonists for GLP-1 R include GLP-1, Boc5, and Cpd1. Following experiments in mouse models, GLP-1 R agonists may also useful in the treatment of acute myocardial infarction.
Potent GLP-1 receptor agonist
| Alternate Names: | Exenatide,AC 2993 |
| Purity: | ≥95% (HPLC) |
Endogenous bioactive GLP-1 receptor ligand
| Purity: | ≥95% (HPLC) |
Highly potent, long-acting GLP-1 receptor agonist
| Alternate Names: | NN2211 |
| Purity: | ≥95% (HPLC) |
Potent GLP-1 receptor antagonist
| Purity: | ≥95% (HPLC) |
Potent insulinotropic peptide
| Alternate Names: | GLP-1 (7-36) amide |
| Purity: | ≥95% (HPLC) |
Endogenous pancreatic peptide
| Alternate Names: | GLP-1 (1-37) amide |
| Purity: | ≥95% (HPLC) |
Metabolite of GLP-1-(7-36) (Cat. No. 2082)
| Alternate Names: | Glucagon-like peptide 1 (9-36) amide |
| Purity: | ≥95% (HPLC) |
Positive allosteric modulator of GLP-1 receptors
| Chemical Name: | 2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)pyrimidine |
| Purity: | ≥98% (HPLC) |
Negative allosteric modulator of glucagon and GLP-1 receptors
| Chemical Name: | 4-[[(4-Cyclohexylphenyl)[[[3-(methylsulfonyl)phenyl]amino]carbonyl]amino]methyl]-N-2H-tetrazol-5-ylbenzamide |
| Purity: | ≥98% (HPLC) |
Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant
| Chemical Name: | 7-(4-Chlorophenyl)-5,8-dihydro-1,3-dimethyl-5,5-bis(trifluoromethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione |
| Purity: | ≥98% (HPLC) |
GSDMD (Gasdermin D) agonist, activator of pyroptosis, also GLP-1R agonist
| Chemical Name: | 6,7-Dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-2-quinoxalinamine |
| Purity: | ≥98% (HPLC) |
