NNC 0640

Name: NNC 0640
Brand: Tocris Bioscience
SKU: 6807

Tocris Bioscience, part of Bio-Techne | Catalog # 6807

COA / SDS

Negative allosteric modulator of glucagon and GLP-1 receptors

Key Product Details

Description:	Negative allosteric modulator of glucagon and GLP-1 receptors
Chemical Name:	4-[[(4-Cyclohexylphenyl)[[[3-(methylsulfonyl)phenyl]amino]carbonyl]amino]methyl]-N-2H-tetrazol-5-ylbenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	573.67

View Full Technical Details for NNC 0640

Technical Data
Citations

Biological Activity for NNC 0640

NNC 0640 is a negative allosteric modulator of glucagon receptors (pK_i = 7.4). Binds to external surface of the transmembrane domain. Also negative allosteric modulator of glucagon-like peptide 1 (GLP-1) receptor. Inhibits GLP-1-mediated cAMP accumulation in vitro.

Technical Data for NNC 0640

M. Wt	573.67
Formula	C₂₉H₃₁N₇O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	307986-98-7
PubChem ID	23549991
InChi Key	PPTKULJUDJWTSA-UHFFFAOYSA-N
Smiles	CS(=O)(C1=CC=CC(NC(N(C2=CC=C(C3CCCCC3)C=C2)CC4=CC=C(C(NC5=NN=NN5)=O)C=C4)=O)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NNC 0640

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	57.37	100

Preparing Stock Solutions for NNC 0640

The following data is based on the product molecular weight 573.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.74 mL	8.72 mL	17.43 mL
5 mM	0.35 mL	1.74 mL	3.49 mL
10 mM	0.17 mL	0.87 mL	1.74 mL
50 mM	0.03 mL	0.17 mL	0.35 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for NNC 0640

References are publications that support the biological activity of the product.

Jazayeri Extra-helical binding site of a glucagon receptor antagonist. Nature. 2016 PMID: 27111510
Song Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature. 2017 PMID: 28514449
Zhang Structure of the full-length glucagon class B g-protein-coupled receptor. Nature. 2017 PMID: 28514451