Glucagon-like peptide 1 (1-37) (human, rat)

Name: Glucagon-like peptide 1 (1-37) (human, rat)
Brand: Tocris Bioscience
SKU: 1851

Tocris Bioscience, part of Bio-Techne | Catalog # 1851

Citations (3)

COA / SDS

Endogenous pancreatic peptide

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Endogenous pancreatic peptide

Alternative Names

GLP-1 (1-37) amide

View all Glucagon-Like Peptide 1 Receptor Agonists »

Product Description

Glucagon-like peptide 1 (1-37) (human, rat) is a pancreatic hormone synthesized by post-translational processing of proglucagon. Unlike truncated forms of GLP-1, it has no effect on food intake in rats and does not enhance pancreatic insulin secretion. However it induces insulin expression in intestinal epithelial cells, which can restore glucose homeostasis when implanted into diabetic mice.

Product Specifications

Molecular Weight

4169.52

Formula

C₁₈₆H₂₇₅N₅₁O₅₉

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

87805-34-3

PubChem ID

16131070

InChI Key

UKVFVQPAANCXIL-FJVFSOETSA-N

SMILES

[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 5mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Navarro Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake. J.Neurochem. 1996 PMID: 8863504
Suzuki Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into Ins-producing cells. Proc.Natl.Acad.Sci.USA
Bell Exon duplication and divergence in the human preproglucagon gene. Nature 1983 PMID: 6877358