DMB
Tocris Bioscience, part of Bio-Techne | Catalog # 8874
GSDMD (Gasdermin D) agonist, activator of pyroptosis, also GLP-1R agonist
Key Product Details
Description
GSDMD (Gasdermin D) agonist, activator of pyroptosis, also GLP-1R agonist
Product Description
DMB is a Gasdermin D (GSDMD) agonist (EC50 = 0.7 mM). DMB directly bound to GSDMD (KD = 1.1 mM). DMB activates GSDMD pore formation and pyroptosis without cleaving GSDMD. In vivo, DMB suppresses tumor growth without harming GSDMD-expressing immune cells in mouse tumor models. DMB is also an agonist of glucagon-like peptide 1 receptor. DMB is orally bioavailable.Product Specifications
Molecular Weight
348.25
Formula
C13H15Cl2N3O2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6,7-Dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-2-quinoxalinamine
CAS Number
281209-71-0
PubChem ID
16007289
InChI Key
GNZCSGYHILBXLL-UHFFFAOYSA-N
SMILES
O=S(=O)(C1=NC=2C=C(Cl)C(Cl)=CC2N=C1NC(C)(C)C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.41 | 50 |
Preparing Stock Solutions
for DMB
The following data is based on the product molecular weight 348.25
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.74 mL | 28.72 mL | 57.43 mL |
| 2.5 mM | 1.15 mL | 5.74 mL | 11.49 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.74 mL |
| 25 mM | 0.11 mL | 0.57 mL | 1.15 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fontana Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity. Cell 2024 PMID: 39243763
Product Specific Notices for DMB
For research use only
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