BETP

Tocris Bioscience, part of Bio-Techne | Catalog # 4778

COA / SDS

Positive allosteric modulator of GLP-1 receptors

Key Product Details

Description:	Positive allosteric modulator of GLP-1 receptors
Chemical Name:	2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)pyrimidine
Purity:	≥98% (HPLC)
Molecular Weight:	406.42

View Full Technical Details for BETP

Technical Data
Citations

Biological Activity for BETP

BETP is a selective positive allosteric modulator and partial agonist of the glucagon-like peptide 1 (GLP-1) receptor. Increases binding affinity of oxyntomodulin for the GLP-1 receptor. Potentiates oxyntomodulin-mediated GLP-1 receptor signaling in vitro and insulin secretion in vivo. Has no effect on GLP-2, GIP, PTH or glucagon receptors.

Compound Libraries for BETP

BETP is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BETP

M. Wt	406.42
Formula	C₂₀H₁₇F₃N₂O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1371569-69-5
PubChem ID	49868481
InChi Key	NTDFYGSSDDMNHI-UHFFFAOYSA-N
Smiles	CCS(C1=NC(C2=CC=CC(OCC3=CC=CC=C3)=C2)=CC(C(F)(F)F)=N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BETP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.64	100
	ethanol	20.32	50

Preparing Stock Solutions for BETP

The following data is based on the product molecular weight 406.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.30 mL	24.61 mL
5 mM	0.49 mL	2.46 mL	4.92 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Molarity Calculator

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Reconstitution Calculator

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References for BETP

References are publications that support the biological activity of the product.

Sloop Novel small molecule glucagon-like peptide-1 receptor agonist stimulates Ins secretion in rodents and from human islets. Diabetes 2010 PMID: 20823098
Cheong Two small molecule agonists of glucagon-like peptide-1 receptor modulate the receptor activation response differently. Biochem.Biophys.Res.Comm. 2012 PMID: 22177947
Willard Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the Insotropic effect of oxyntomodulin. Mol.Pharmacol. 2012 PMID: 22930710