Exendin-3 (9-39) amide

Name: Exendin-3 (9-39) amide
Brand: Tocris Bioscience
SKU: 2081

Tocris Bioscience, part of Bio-Techne | Catalog # 2081

Citations (66)

COA / SDS

Potent GLP-1 receptor antagonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent GLP-1 receptor antagonist

View all Glucagon-Like Peptide 1 Receptor Antagonists »

Product Description

Exendin-3 (9-39) amide is a potent and selective GLP-1 receptor antagonist (K_d = 1.7 nM at cloned human GLP-1 receptors). Inhibits cAMP production and insulin release induced by GLP-1 (7-36), exendin-3 (IC₅₀ = 20 nM) and exendin-4. Blocks the inhibitory effect of GLP-1 on food intake in rats.

Product Specifications

Molecular Weight

3369.79

Formula

C₁₄₉H₂₃₄N₄₀O₄₇S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

133514-43-9

PubChem ID

16198321

InChI Key

WSEVKKHALHSUMB-MVNVRWBSSA-N

SMILES

[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Turton A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996 PMID: 8538742
Goke Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of Ins-Secr.g β-cells. J.Biol.Chem. 1993 PMID: 8396143
Thorens Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 1993 PMID: 8405712
Raufman Exendin-3, a novel peptide from the Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. J.Biol.Chem. 1991 PMID: 1704369