156 results for "Degrader Building Blocks Small Molecules and Peptides" in Products

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Degrader Building Blocks: Small Molecules and Peptides

Pomalidomide 4'-PEG4-azide

Catalog #: 7436
Product Documents

Cereblon ligand with PEG linker and terminal azide for onward chemistry

Chemical Name: 4-[(14-Azido-3,6,9,12-tetraoxatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Cereblon ligand with PEG linker and terminal azide for onward chemistry

VH 032 amide-PEG3-BCN

Catalog #: 8123
Product Documents

Functionalized VHL building block for copper-free click chemistry

Chemical Name: ((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl ((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)carbamate
Purity: ≥90% (HPLC)
Functionalized VHL building block for copper-free click chemistry

Angiopep-2

Catalog #: 8828
Product Documents

Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB

Purity: ≥95% (HPLC)
Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB

tri-GalNAc-C5-amine

Catalog #: 7781
Citations (1)
Product Documents

Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry

Chemical Name: N-[2-[[1-[2-[2-[2-[2-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]-1,1-bis[[[1-[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]methyl]ethyl]-6-aminohexanamide
Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry

tri-GalNAc COOH

Catalog #: 7401
Product Documents

Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry

Chemical Name: 36-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontanoic acid
Purity: ≥90% (HPLC)
Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry

N-methylated pomalidomide

Catalog #: 7716
Product Documents

Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control

Chemical Name: 4-Amino-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control

TransMoDE 3 Biotin

Catalog #: 8829
Product Documents

Biotinylated angiopep-2, induces internalization and degradation of streptavidin in brain cell lines

Purity: ≥95% (HPLC)
Biotinylated angiopep-2 induces internalization and degradation of streptavidin in brain cell lines

VH 032, amine

Catalog #: 6462
Citations (1)
Product Documents

Functionalized VHL ligand for PROTACs

Chemical Name: (4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride
Purity: ≥98% (HPLC)
Functionalized VHL ligand for PROTACs

VH 032 amide-PEG3-amine

Catalog #: 6463
Citations (1)
Product Documents

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-PEG3-NH2
Chemical Name: (2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with PEG linker and terminal amine for onward chemistry

VHF 543, amine

Catalog #: 8075
Product Documents

DCAF1 WD40 ligand with terminal amine for onward chemistry

Chemical Name: 1-(4-(4-((2-Aminoethyl)amino)-2-(1-(4-chlorophenyl)cyclohexyl)quinazolin-7-yl)piperazin-1-yl)ethan-1-one
Purity: ≥98% (HPLC)
DCAF1 WD40 ligand with terminal amine for onward chemistry

VH 032 amide-PEG2-amine

Catalog #: 6907
Product Documents

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-PEG2-NH2
Chemical Name: (2S,4R)-1-((S)-2-(2-(2-(2-Aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥95% (HPLC)
VHL ligand with PEG linker and terminal amine for onward chemistry

VH 032 amide-PEG1-amine

Catalog #: 6879
Product Documents

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-PEG1-NH2
Chemical Name: (2S,4R)-1-((S)-2-(2-(2-Aminoethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with PEG linker and terminal amine for onward chemistry

tri-GalNAc-PEG3-Azide

Catalog #: 8015
Citations (1)
Product Documents

Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry

Purity: ≥90% (HPLC)
Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry

Pomalidomide 4'-PEG2-azide

Catalog #: 7307
Product Documents

Cereblon ligand with PEG linker and terminal azide for onward chemistry

Chemical Name: 4-[[2-[2-(2-Azidoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Cereblon ligand with PEG linker and terminal azide for onward chemistry

VH 032, thiol

Catalog #: 7861
Citations (1)
Product Documents

Functionalized VHL ligand for PROTAC® development

Chemical Name: (2S,4R)-1-((R)-2-Acetamido-3-mercapto-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥95% (HPLC)
Functionalized VHL ligand for PROTAC® development

Pomalidomide 4'-alkylC6-amine

Catalog #: 7923
Product Documents

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name: 4-[(6-Aminohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal amine for onward chemistry

VH 101, acid

Catalog #: 7758
Product Documents

VHL ligand, carboxylic acid functionalized at the benzylic position

Chemical Name: (S)-3-[[[(2S,4R)-1-[(S)-2-(1-Fluorocyclopropan-1-ylcarbonylamino)-3,3-dimethylbutanoyl]-4-hydroxypyrrolidin-2-yl]carbonyl]amino]-3-[4-(4-methylthiazol-5-yl)phenyl]propanoic acid
Purity: ≥98% (HPLC)
VHL ligand, carboxylic acid functionalized at the benzylic position

Pomalidomide 4'-alkylC5-azide

Catalog #: 7442
Product Documents

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Chemical Name: 4-[(5-Azidopentyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Thalidomide 4'-ether-alkylC8-acid

Catalog #: 7335
Product Documents

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Chemical Name: 9-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]nonanoic acid
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Thalidomide 4'-ether-alkylC6-acid

Catalog #: 7333
Product Documents

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Chemical Name: 7-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]heptanoic acid
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal acid for onward chemistry

5-Amino-Thalidomide

Catalog #: 7678
Product Documents

Cereblon ligand with amine on C5 for onward chemistry

Chemical Name: 5-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Cereblon ligand with amine on C5 for onward chemistry

VH 032 amide-alkylC2-amine

Catalog #: 6852
Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-C2-NH2
Chemical Name: (2S,4R)-1-((S)-2-(3-Aminopropanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal amine for onward chemistry

Lenalidomide 4'-alkylC5-azide

Catalog #: 7517
Product Documents

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Chemical Name: 3-[4-[(5-Azidopentyl)amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal azide for onward chemistry

VH 032 amide-alkylC6-amine

Catalog #: 6853
Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names: VH 032 - linker 8,(S,R,S)-AHPC-C2-NH2
Chemical Name: (2S,4R)-1-((S)-2-(7-Aminoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal amine for onward chemistry

(+)-JQ1 bump-N, acid functionalized

Catalog #: 8827
Product Documents

Negative control for (+)-JQ1 bump, acid functionalized (Cat. No. 7689)

Chemical Name: (S)-2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)butanoic acid
Purity: ≥98% (HPLC)
Negative control for (+)-JQ1 bump, acid functionalized (Cat. No. 7689)
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