Degrader Building Blocks: Small Molecules and Peptides

VH 032 amide-PEG3-BCN

Functionalized VHL building block for copper-free click chemistry

Chemical Name:	((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl ((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)carbamate
Purity:	≥90% (HPLC)

VH 032, amine

Catalog #: 6462

Citations (1)

Product Documents

Functionalized VHL ligand for PROTACs

Chemical Name:	(4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride
Purity:	≥98% (HPLC)

tri-GalNAc biotin

Catalog #: 7635

Product Documents

Biotinylated ASGPR ligand for LYTAC research and development

Purity:

≥90% (HPLC)

VH 032 amide-alkylC5-azide

Catalog #: 7867

Product Documents

VHL ligand with alkylC5 linker and terminal azide for onward chemistry

Chemical Name:	(2S,4R)-1-((S)-2-(6-Azidohexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥95% (HPLC)

VH 101, phenol

Catalog #: 6952

Citations (1)

Product Documents

Hydroxyl functionalized VHL ligand

Chemical Name:	(2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)

Pomalidomide 4'-PEG3-azide

Catalog #: 7435

Product Documents

Cereblon ligand with PEG linker and terminal azide for onward chemistry

Chemical Name:	4-[[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity:	≥95% (HPLC)

tri-GalNAc-PEG3-Azide

Catalog #: 8015

Product Documents

Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry

Purity:

≥90% (HPLC)

tri-GalNAc-C5-amine

Catalog #: 7781

Citations (1)

Product Documents

Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry

Chemical Name:

N-[2-[[1-[2-[2-[2-[2-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]-1,1-bis[[[1-[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]methyl]ethyl]-6-aminohexanamide

Pomalidomide 4'-alkylC2-azide

Catalog #: 7439

Product Documents

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Chemical Name:	4-[(2-Azidoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity:	≥95% (HPLC)

tri-GalNAc COOH

Catalog #: 7401

Product Documents

Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry

Chemical Name:	36-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontanoic acid
Purity:	≥90% (HPLC)

N-methylated pomalidomide

Catalog #: 7716

Product Documents

Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control

Chemical Name:	4-Amino-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity:	≥95% (HPLC)

Thalidomide, 5'-fluoro

Catalog #: 7456

Product Documents

Fluoro functionalized Thalidomide; cereblon ligand for PROTACs

Chemical Name:	2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-1H-isoindole-1,3(2H)-dione
Purity:	≥95%

Lenalidomide 4'-PEG1-azide

Catalog #: 7513

Product Documents

Cereblon ligand with PEG linker and terminal azide for onward chemistry

Chemical Name:	3-[4-[[2-(2-Azidoethoxy)ethyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
Purity:	≥95% (HPLC)

Lenalidomide 4'-alkylC3-azide

Catalog #: 7516

Product Documents

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Chemical Name:	3-[4-[(3-Azidopropyl)amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
Purity:	≥95% (HPLC)

Thalidomide 4'-ether-alkylC3-azide

Catalog #: 7521

Product Documents

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Chemical Name:	4-(3-Azidopropoxy)-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
Purity:	≥95% (HPLC)

VH 032 amide-alkylC9-amine

Catalog #: 7566

Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C9-NH₂
Chemical Name:	(2S,4R)-1-((S)-2-(10-Aminodecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

Thalidomide 4'-ether-PEG1-azide

Catalog #: 7518

Product Documents

Cereblon ligand with PEG linker and terminal azide for onward chemistry

Chemical Name:	4-(2-(2-Azidoethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
Purity:	≥95% (HPLC)

LCL 161, phenol

Catalog #: 7178

Product Documents

Functionalized IAP ligand for PROTACs

Chemical Name:	tert-Butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
Purity:	≥95% (HPLC)

Lenalidomide 4'-PEG2-azide

Catalog #: 7514

Product Documents

Cereblon ligand with PEG linker and terminal azide for onward chemistry

Chemical Name:	3-[4-[[2-[2-(2-Azidoethoxy)ethoxy]ethyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
Purity:	≥95% (HPLC)

VH 032, propargyl

Catalog #: 6683

Citations (1)

Product Documents

Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs

Chemical Name:	(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(prop-2-yn-1-yloxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥95% (HPLC)

VH 101 phenol-alkylC4-amine

Catalog #: 7293

Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name:	(2S,4R)-N-(2-(4-Aminobutoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

Pomalidomide 4'-PEG1-azide

Catalog #: 7434

Product Documents

Cereblon ligand with PEG linker and terminal azide for onward chemistry

Chemical Name:	4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity:	≥95% (HPLC)

Thalidomide 4'-ether-alkylC6-azide

Catalog #: 7829

Product Documents

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Chemical Name:	4-[(6-Azidohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity:	≥95% (HPLC)

Lenalidomide 4'-alkylC5-azide

Catalog #: 7517

Product Documents

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Chemical Name:	3-[4-[(5-Azidopentyl)amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
Purity:	≥95% (HPLC)

Pomalidomide 4'-alkylC2-amine

Catalog #: 6851

Product Documents

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	Pomalidomide - linker 7
Chemical Name:	4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity:	≥95% (HPLC)

Degrader Building Blocks: Small Molecules and Peptides

VH 032 amide-PEG3-BCN

VH 032, amine

tri-GalNAc biotin

VH 032 amide-alkylC5-azide

VH 101, phenol

Pomalidomide 4'-PEG3-azide

tri-GalNAc-PEG3-Azide

tri-GalNAc-C5-amine

Pomalidomide 4'-alkylC2-azide

tri-GalNAc COOH

N-methylated pomalidomide

Thalidomide, 5'-fluoro

Lenalidomide 4'-PEG1-azide

Lenalidomide 4'-alkylC3-azide

Thalidomide 4'-ether-alkylC3-azide

VH 032 amide-alkylC9-amine

Thalidomide 4'-ether-PEG1-azide

LCL 161, phenol

Lenalidomide 4'-PEG2-azide

VH 032, propargyl

VH 101 phenol-alkylC4-amine

Pomalidomide 4'-PEG1-azide

Thalidomide 4'-ether-alkylC6-azide

Lenalidomide 4'-alkylC5-azide

Pomalidomide 4'-alkylC2-amine

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