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156 results for "Degrader Building Blocks" in Products

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Degrader Building Blocks

tri-GalNAc COOH

Catalog #: 7401

Product Documents

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Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry

Chemical Name:

36-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontanoic acid

Purity:

≥90%

tri-GalNAc biotin

Catalog #: 7635

Product Documents

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Biotinylated ASGPR ligand for LYTAC research and development

Purity:

≥90%

VH 032 amide-alkylC2-amine

Catalog #: 6852

Product Documents

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VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-C2-NH₂

Chemical Name:

(2S,4R)-1-((S)-2-(3-Aminopropanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 032 amide-PEG2-amine

Catalog #: 6907

Product Documents

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VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-PEG2-NH₂

Chemical Name:

(2S,4R)-1-((S)-2-(2-(2-(2-Aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity:

≥95%

Pomalidomide 4'-alkylC3-acid

Catalog #: 7096

Product Documents

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Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Chemical Name:

4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]butanoic acid

Purity:

≥95%

VH 032 amide-alkylC2-acid

Catalog #: 7106

Product Documents

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VHL ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names:

(S,R,S)-AHPC-C2-COOH

Chemical Name:

4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

Purity:

≥95%

Pomalidomide 4'-PEG2-acid

Catalog #: 7212

Product Documents

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Cereblon ligand with PEG linker and terminal acid for onward chemistry

Chemical Name:

3-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]propanoic acid

Purity:

≥95%

VH 101 phenol-alkylC4-amine

Catalog #: 7293

Product Documents

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VHL ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name:

(2S,4R)-N-(2-(4-Aminobutoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 101 phenol-alkylC6-amine

Catalog #: 7294

Product Documents

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VHL ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name:

(2S,4R)-N-(2-((6-Aminohexyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

Pomalidomide 4'-PEG1-azide

Catalog #: 7434

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Cereblon ligand with PEG linker and terminal azide for onward chemistry

Chemical Name:

4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

Purity:

≥95%

Pomalidomide 4'-alkylC2-azide

Catalog #: 7439

Product Documents

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Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Chemical Name:

4-[(2-Azidoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

Purity:

≥95%

Lenalidomide 5'-piperazine-4-methylpiperidine

Catalog #: 7473

Product Documents

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Cereblon ligand with terminal piperidine for onward chemistry

Chemical Name:

3-[1,3-Dihydro-1-oxo-5-[4-(4-piperidinylmethyl)-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione dihydrochloride

Purity:

≥94%

Thalidomide 4'-oxyacetamide-alkylC4-azide

Catalog #: 6300

Product Documents

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Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Alternate Names:

Azido-Thalidomide

Chemical Name:

N-(4-Azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide

Purity:

≥98%

VH 032, amine

Catalog #: 6462

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Functionalized VHL ligand for PROTACs

Chemical Name:

(4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride

Purity:

≥98%

VH 032 amide-PEG3-amine

Catalog #: 6463

Product Documents

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VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-PEG3-NH₂

Chemical Name:

(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 032 amide-PEG4-amine

Catalog #: 6464

(1)

Product Documents

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VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-PEG4-NH₂

Chemical Name:

(2S,4R)-1-((S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 032 amide-alkylC4-amine

Catalog #: 6465

(1)

Product Documents

Images (1)

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-C4-NH₂

Chemical Name:

(2S,4R)-1-((S)-2-(5-aminopentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

Thalidomide-4-hydroxyacetate

Catalog #: 6466

Product Documents

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Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs

Chemical Name:

2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid

Purity:

≥98%

Thalidomide 4'-oxyacetamide-PEG3-amine

Catalog #: 6467

(1)

Product Documents

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Cereblon ligand with PEG linker and terminal amine for onward chemistry

Alternate Names:

Thalidomide - linker 1

Chemical Name:

N-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride

Purity:

≥95%

A 410099.1, amine

Catalog #: 6471

Product Documents

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Functionalized IAP ligand for PROTACs

Chemical Name:

tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-amino-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate hydrochloride

Purity:

≥98%

A 410099.1 amide-PEG3-amine

Catalog #: 6472

Product Documents

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IAP ligand with PEG linker and terminal amine for onward chemistry

Chemical Name:

tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-[2-[2-2-[(2-aminoethoxy)ethoxy]ethoxy]acetamido]-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate

Purity:

≥95%

A 410099.1 amide-PEG2-amine

Catalog #: 6473

Product Documents

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IAP ligand with PEG linker and terminal amine for onward chemistry

Chemical Name:

tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-[2-[2-(2-aminoethoxy)ethoxy]acetamido]-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate

Purity:

≥95%

A 410099.1 amide-alkylC4-amine

Catalog #: 6474

Product Documents

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IAP ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name:

tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-(5-Aminopentanamido)-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate

Purity:

≥95%

Thalidomide 4'-ether-alkylC6-amine

Catalog #: 6627

(1)

Product Documents

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Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:

Thalidomide - linker 4

Chemical Name:

4-[(6-Aminohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride

Purity:

≥95%

Pomalidomide 4'-PEG2-amine

Catalog #: 6637

(1)

Product Documents

Images (1)

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Alternate Names:

Pomalidomide - linker 1

Chemical Name:

4-[[2-[2-(2-Aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride

Purity:

≥95%

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