Thalidomide 4'-oxyacetamide-alkylC4-azide
Tocris Bioscience, part of Bio-Techne | Catalog # 6300
Cereblon ligand with alkyl linker and terminal azide for onward chemistry
Key Product Details
Description
Cereblon ligand with alkyl linker and terminal azide for onward chemistry
Alternative Names
Azido-Thalidomide
Product Description
Thalidomide 4'-oxyacetamide-alkylC4-azide is a click-activated Thalidomide (Cat.No. 0652); precursor to PROTAC® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with an azide functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.This product has been recently renamed. The previous name for this product was Azido-Thalidomide
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines
This product is provided for use in onward chemistry. Suitable solvents can be used.Product Specifications
Molecular Weight
428.40
Formula
C19H20N6O6
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(4-Azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
CAS Number
2098488-36-7
PubChem ID
131704500
InChI Key
USWFAZSQVLTHHA-UHFFFAOYSA-N
SMILES
[N-]=[N+]=NCCCCNC(COC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Schiedel Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals). J.Med.Chem. 2018 PMID: 28379698
Product Specific Notices for Thalidomide 4'-oxyacetamide-alkylC4-azide
For research use only
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