Thalidomide-4-hydroxyacetate
Tocris Bioscience, part of Bio-Techne | Catalog # 6466
Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs
Key Product Details
Description
Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs
Product Description
Thalidomide-4-hydroxyacetate is a derivative of Thalidomide (Cat.No. 0652), commonly used as a precursor to PROTAC® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with a carboxylic acid functional handle at a position known not to significantly affect binding to cereblon, for ready conjugation to a linker/target protein ligand.Thalidomide-4-hydroxyacetate has been recently renamed. The previous name for this product was TC E3 5031.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
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Usage Guidelines
This product is provided for use in onward chemistry. Suitable solvents can be used.Product Specifications
Molecular Weight
332.26
Formula
C15H12N2O7
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid
CAS Number
1061605-21-7
PubChem ID
25015436
InChI Key
ZVWIXIGBWIEDFO-UHFFFAOYSA-N
SMILES
O=C(N1C(CC2)C(NC2=O)=O)C3=C(C1=O)C(OCC(O)=O)=CC=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lohbeck and Miller Practical synthesis of a phthalimide-based cereblon ligand to enable PROTAC development. Bioorg.Med.Chem.Lett. 2016 PMID: 27687673
Product Specific Notices for Thalidomide-4-hydroxyacetate
For research use only
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