VH 032 amide-alkylC4-amine

Tocris Bioscience, part of Bio-Techne | Catalog # 6465

VHL ligand with alkyl linker and terminal amine for onward chemistry
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Key Product Details

Description

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternative Names

(S,R,S)-AHPC-C4-NH2

View all VHL Ligands Plus Linker Building Blocks »

Product Description

VH 032 amide-alkylC4-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand plus a short alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was VH 032 - linker 3

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications

Molecular Weight

602.62

Formula

C27H39N5O4S.2HCl

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(2S,4R)-1-((S)-2-(5-aminopentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

CAS Number

2341796-78-7

PubChem ID

134160245

InChI Key

QBJGQVIKGJREIR-IYCRVZLISA-N

SMILES

O=C(N[C@@H](C(C)(C)C)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)=O)CCCCN.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for VH 032 amide-alkylC4-amine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VH 032 amide-alkylC4-amine

For research use only

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