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43 results for "Compounds for Induced Pluripotent Stem Cells" in Products

Compounds for Induced Pluripotent Stem Cells

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

GMP Version Available: TB1614-GMP
GMP
Chemical Name:
4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Purity:
≥99%
dopaminergic neurons derived from hiPSCs using SB 431542
(2)

Highly selective GSK-3 inhibitor; acts as Wnt activator

GMP Version Available: TB4423-GMP
GMP
Alternate Names:
CHIR99021,CT99021
Chemical Name:
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Purity:
≥98%
Cardiomyocyte derived from human induced pluripotent stem cells (hiPSCs) using CHIR 99021.
(2)

SB 431542 synthesized to cGMP guidelines

Chemical Name:
4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Purity:
≥99%
SB 431542 synthesized to cGMP guidelines

EZH2 histone methyltransferase inhibitor

Alternate Names:
DZNep,NSC 617989,HY-12186
Chemical Name:
(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride
Purity:
≥98%
EZH2 histone methyltransferase inhibitor

CHIR 99021 synthesized to cGMP guidelines

Chemical Name:
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Purity:
≥99%
CHIR 99021 synthesized to cGMP guidelines
(2)

Adenylyl cyclase activator

Alternate Names:
Coleonol,Colforsin
Chemical Name:
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
Purity:
≥98%
Adult Stem Cell-derived Liver Organoids
(2)

Selective inhibitor of TGF-βRI, ALK4 and ALK7

Chemical Name:
3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Purity:
≥98%
Adult Stem Cell-derived Liver Organoids
(6)

PORCN inhibitor; inhibits Wnt processing and secretion

Chemical Name:
N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Purity:
≥98%
iPSC-derived heart organoids differentiated with IWP 2 and CHIR 99021
(2)

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Chemical Name:
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
Purity:
≥99%
Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Potent inhibitor of MEK1/2

Alternate Names:
PD325901
Chemical Name:
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
Purity:
≥99%
Potent inhibitor of MEK1/2

Wnt/β-catenin signaling inhibitor; axin stabilizer

Chemical Name:
rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide
Purity:
≥98%
Wnt/β-catenin signaling inhibitor; axin stabilizer

Potent tankyrase inhibitor

GMP Version Available: TB3748-GMP
GMP
Alternate Names:
XAV939 Wnt Signaling Inhibitor
Chemical Name:
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Purity:
≥98%
Potent tankyrase inhibitor

p53 inhibitor. Also aryl hydrocarbon receptor agonist

Chemical Name:
1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide
p53 inhibitor. Also aryl hydrocarbon receptor agonist

Histone deacetylase inhibitor

Alternate Names:
VPA,Sodium Valproate
Chemical Name:
Sodium 2-propylpentanoate
Histone deacetylase inhibitor

XAV 939 synthesized to cGMP guidelines

Chemical Name:
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
Purity:
≥99%
XAV 939 synthesized to cGMP guidelines

CK1 inhibitor

Chemical Name:
N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride
Purity:
≥99%
CK1 inhibitor

Retinoic acid analog; RAR agonist

Alternate Names:
Ro 13-7410
Chemical Name:
4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid
Purity:
≥98%
Retinoic acid analog; RAR agonist

Inhibitor of Hedgehog (Hh) signaling

Chemical Name:
(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol
Purity:
≥97%
Inhibitor of Hedgehog (Hh) signaling

Potent histone deacetylase inhibitor

Chemical Name:
(2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Purity:
≥95%
Potent histone deacetylase inhibitor

ROCK inhibitor; improves the efficiency of fibroblast reprogramming and induction of iPSCs

Chemical Name:
N-Benzyl-[2-(pyrimidin-4-yl)amino]thiazole-4-carboxamide
Purity:
≥98%
ROCK inhibitor ; improves the efficiency of fibroblast reprogramming and induction of iPSCs

Histone deacetylase inhibitor

Chemical Name:
Butanoic acid sodium salt
Histone deacetylase inhibitor

Irreversible inhibitor of LSD1; also inhibits MAO

Alternate Names:
2-PCPA
Chemical Name:
(±)-trans-2-Phenylcyclopropylamine hydrochloride
Purity:
≥98%
Irreversible inhibitor of LSD1; also inhibits MAO

CaV1.x activator

Chemical Name:
1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester
Purity:
≥98%
CaV1.x activator

Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

Chemical Name:
N-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide
Purity:
≥98%
Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes

Media supplement to boost cell growth; used as component of CEPT cocktail to enhance stem cell viability

Lyophilized Polyamine Supplement x1000 | Media supplement to boost cell growth; used as component of CEPT cocktail to enhance stem cell viability
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