23 results for "Additional RTK Inhibitors Small Molecules and Peptides" in Products
Additional RTK Inhibitors: Small Molecules and Peptides
VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
| Alternate Names: | Semaxinib |
| Chemical Name: | 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one |
| Purity: | ≥98% (HPLC) |
Potent and selective FGFR inhibitor
| Chemical Name: | rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide |
| Purity: | ≥98% (HPLC) |
Potent CSF-1R inhibitor
| Chemical Name: | N-[5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine |
| Purity: | ≥98% (HPLC) |
c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation
| Chemical Name: | N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]urea |
| Purity: | ≥97% (HPLC) |
Selective cFMS kinase inhibitor; orally bioavailable
| Chemical Name: | 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine |
| Purity: | ≥98% (HPLC) |
Selective DDR1 inhibitor
| Chemical Name: | N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide dihydrochloride |
| Purity: | ≥98% (HPLC) |
Potent RET inhibitor
| Chemical Name: | 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity: | ≥98% (HPLC) |
Dual Mer/Axl inhibitor
| Chemical Name: | 3-[4-[(Dimethylamino)methyl]phenyl]-N-methyl-N-[5-[3-methyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-pyridinyl]-1,3,4-oxadiazol-2-yl]imidazo[1,2-a]pyridine-6-methanamine |
| Purity: | ≥97% (HPLC) |
Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R
| Chemical Name: | N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea |
| Purity: | ≥98% (HPLC) |
Potent and selective dual inhibitor of the IGF-1 receptor and insulin receptor
| Chemical Name: | cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol |
| Purity: | ≥98% (HPLC) |
Potent and selective PDGFR family inhibitor
| Chemical Name: | N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor
| Chemical Name: | 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide |
| Purity: | ≥98% (HPLC) |
Potent VEGFR inhibitor; also inhibits other RTKs
| Alternate Names: | Cabozantinib,BMS 907351 |
| Chemical Name: | N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide |
| Purity: | ≥98% (HPLC) |
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
| Chemical Name: | 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine |
| Purity: | ≥98% (HPLC) |
Potent VEGFR, PDGFRβ and KIT inhibitor
| Alternate Names: | SU 11248 |
| Chemical Name: | N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioate salt |
| Purity: | ≥98% (HPLC) |
Potent Tie2 inhibitor
| Chemical Name: | [3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur |
| Purity: | ≥98% (HPLC) |
Potent Mer kinase inhibitor
| Chemical Name: | 2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent and selective RET inhibitor
| Chemical Name: | 6-(2-Hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]hept-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile |
| Purity: | ≥98% (HPLC) |
Potent and selective DDR1 inhibitor; orally bioavailable
| Chemical Name: | 4-Ethyl-N-[3-[(4-methyl-1-piperazinyl)methyl]-5-(trifluoromethyl)phenyl]-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide |
| Purity: | ≥98% (HPLC) |
Zap70 inhibitor; inhibits interaction with ITAMs
| Chemical Name: | 5-Chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-4-pyrimidinecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent and selective discoidin domain receptor 1/2 inhibitor
| Chemical Name: | 4-Fluoro-3-[[[5-(1-methyl-1H-pyrazol-3-yl)-3-pyridinyl]methyl]amino]-N-[3-(trifluoromethoxy)phenyl]benzamide |
| Purity: | ≥98% (HPLC) |
Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
| Chemical Name: | 3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride |
| Purity: | ≥98% (HPLC) |
Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons
| Chemical Name: | 4-[[6-[(Cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzeneacetamide |
| Purity: | ≥98% (HPLC) |
