UNC 2881

Name: UNC 2881
Brand: Tocris Bioscience
SKU: 6537

Tocris Bioscience, part of Bio-Techne | Catalog # 6537

COA / SDS

Potent Mer kinase inhibitor

Key Product Details

Description:	Potent Mer kinase inhibitor
Chemical Name:	2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	463.58

View Full Technical Details for UNC 2881

Technical Data
Citations

Biological Activity for UNC 2881

UNC 2881 is a potent Mer kinase inhibitor. Displays >55-fold selectivity for Mer kinase over other TAM receptor tyrosine kinase family members (IC₅₀ values are 4.3 nM, 0.25 μM and 0.36 μM for Mer, Tyro3 and Alk, respectively). Inhibits Mer phosphorylation in vitro. Also inhibits platelet aggregation in response to Type I collagen.

Compound Libraries for UNC 2881

UNC 2881 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for UNC 2881

M. Wt	463.58
Formula	C₂₅H₃₃N₇O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1493764-08-1
PubChem ID	71721525
InChi Key	NPVXOWLPOFYACO-UHFFFAOYSA-N
Smiles	CCCCNC1=NC=C(C(N[C@H]2CC[C@@H](CC2)O)=N1)C(NCC3=CC=C(N4C=CN=C4)C=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UNC 2881

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.18	50

Preparing Stock Solutions for UNC 2881

The following data is based on the product molecular weight 463.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.31 mL	21.57 mL	43.14 mL
2.5 mM	0.86 mL	4.31 mL	8.63 mL
5 mM	0.43 mL	2.16 mL	4.31 mL
25 mM	0.09 mL	0.43 mL	0.86 mL

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References for UNC 2881

References are publications that support the biological activity of the product.

Zhang Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J.Med.Chem. 2013 PMID: 24219778