VU 6015929

Name: VU 6015929
Brand: Tocris Bioscience
SKU: 7728

Tocris Bioscience, part of Bio-Techne | Catalog # 7728

COA / SDS

Potent and selective discoidin domain receptor 1/2 inhibitor

Key Product Details

Description:	Potent and selective discoidin domain receptor 1/2 inhibitor
Chemical Name:	4-Fluoro-3-[[[5-(1-methyl-1H-pyrazol-3-yl)-3-pyridinyl]methyl]amino]-N-[3-(trifluoromethoxy)phenyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	485.43

View Full Technical Details for VU 6015929

Technical Data
Citations

Biological Activity for VU 6015929

VU 6015929 is a potent and selective discoidin domain receptor 1/2 (DDR1/2) inhibitor (IC₅₀ = 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively). VU 6015929 blocks collagen-induced DDR1 activation and collagen-IV production in HEK293 cells.

Technical Data for VU 6015929

M. Wt	485.43
Formula	C₂₄H₁₉F₄N₅O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2442597-56-8
PubChem ID	145925694
InChi Key	IZKVIUJIUTXIRH-UHFFFAOYSA-N
Smiles	O=C(NC=1C=CC=C(OC(F)(F)F)C1)C2=CC=C(F)C(=C2)NCC3=CN=CC(=C3)C4=NN(C=C4)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VU 6015929

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	48.54	100
	ethanol	9.71	20

Preparing Stock Solutions for VU 6015929

The following data is based on the product molecular weight 485.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.06 mL	10.30 mL	20.60 mL
5 mM	0.41 mL	2.06 mL	4.12 mL
10 mM	0.21 mL	1.03 mL	2.06 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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References for VU 6015929

References are publications that support the biological activity of the product.

Jeffries Discovery of VU6015929: a selective discoidin domain receptor 1/2 (DDR1/2) inhibitor to explore the role of DDR1 in antifibrotic therapy. ACS Med.Chem.Lett. 2019 PMID: 31938459
Sun Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion. Nature 2021 PMID: 34732895