Additional RTK Inhibitors Small Molecules and Peptides

c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation

VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3

Potent and selective PDGFR family inhibitor

Selective DDR1 inhibitor

Potent CSF-1R inhibitor

Potent and selective FGFR inhibitor

Potent VEGFR, PDGFRβ and KIT inhibitor

PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

Potent RET inhibitor

PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk

Selective cFMS kinase inhibitor; orally bioavailable

Potent and selective DDR1 inhibitor; orally bioavailable

Potent Mer kinase inhibitor

Potent Tie2 inhibitor

Zap70 inhibitor; inhibits interaction with ITAMs

Potent and selective dual inhibitor of the IGF-1 receptor and insulin receptor

Potent and selective RET inhibitor

Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor

Potent and selective discoidin domain receptor 1/2 inhibitor

Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R

Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons

Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons