AC 710
Tocris Bioscience, part of Bio-Techne | Catalog # 5013
Potent and selective PDGFR family inhibitor
Key Product Details
Description
Potent and selective PDGFR family inhibitor
Product Description
AC 710 is a potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.Product Specifications
Molecular Weight
562.70
Formula
C31H42N6O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide
CAS Number
1351522-04-7
PubChem ID
54760053
InChI Key
JVCWPUFNLFSKFS-UHFFFAOYSA-N
SMILES
CC(C2)(C)N(CC)C(C)(C)CC2OC1=CC=C(C(NC3=CC=C(NC(NC4=NOC(C(C)(C)C)=C4)=O)C=C3)=O)N=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.25 | 20 |
Preparing Stock Solutions
for AC 710
The following data is based on the product molecular weight 562.70
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 8.89 mL | 44.43 mL | 88.86 mL |
| 1 mM | 1.78 mL | 8.89 mL | 17.77 mL |
| 2 mM | 0.89 mL | 4.44 mL | 8.89 mL |
| 10 mM | 0.18 mL | 0.89 mL | 1.78 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Liu Discovery of AC710, a globally selective inhibitor of platelet-derived growth factor receptor-family kinases. ACS Med.Chem.Lett. 2012 PMID: 24900421
Product Specific Notices for AC 710
For research use only
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