VHL: Small Molecules and Peptides

VH 032, amine

Functionalized VHL ligand for PROTACs

Chemical Name:	(4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride
Purity:	≥98% (HPLC)

VH 032 amide-alkylC5-azide

Catalog #: 7867

Product Documents

VHL ligand with alkylC5 linker and terminal azide for onward chemistry

Chemical Name:	(2S,4R)-1-((S)-2-(6-Azidohexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥95% (HPLC)

VH 101, phenol

Catalog #: 6952

Citations (1)

Product Documents

Hydroxyl functionalized VHL ligand

Chemical Name:	(2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)

VH 032 amide-PEG3-BCN

Catalog #: 8123

Product Documents

Functionalized VHL building block for copper-free click chemistry

Chemical Name:	((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl ((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)carbamate
Purity:	≥90% (HPLC)

VH 032 amide-alkylC9-amine

Catalog #: 7566

Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C9-NH₂
Chemical Name:	(2S,4R)-1-((S)-2-(10-Aminodecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

VH 101 phenol-alkylC4-amine

Catalog #: 7293

Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name:	(2S,4R)-N-(2-(4-Aminobutoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

VH 032, propargyl

Catalog #: 6683

Citations (1)

Product Documents

Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs

Chemical Name:	(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(prop-2-yn-1-yloxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥95% (HPLC)

VH 032 amide-alkylC4-amine

Catalog #: 6465

Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C4-NH₂
Chemical Name:	(2S,4R)-1-((S)-2-(5-aminopentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

VH 032 amide-PEG4-amine

Catalog #: 6464

Product Documents

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-PEG4-NH₂
Chemical Name:	(2S,4R)-1-((S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

VH 032 amide-alkylC2-acid

Catalog #: 7106

Product Documents

VHL ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C2-COOH
Chemical Name:	4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid
Purity:	≥95% (HPLC)

VH 101 phenol-alkylC6-amine

Catalog #: 7294

Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name:	(2S,4R)-N-(2-((6-Aminohexyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

VH 032

Catalog #: 7774

Product Documents

Inhibitor of VHL; blocks interaction of VHL and HIF-α

Chemical Name:	(2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)

VH 032 amide-PEG2-amine

Catalog #: 6907

Product Documents

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-PEG2-NH₂
Chemical Name:	(2S,4R)-1-((S)-2-(2-(2-(2-Aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥95% (HPLC)

VH 032 amide-alkylC5-amine

Catalog #: 6985

Citations (5)

Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C5-NH₂
Chemical Name:	(2S,4R)-1-((S)-2-(6-Aminohexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

VH 032 amide-PEG2-acid

Catalog #: 7214

Product Documents

VHL ligand with PEG linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-PEG2-COOH
Chemical Name:	3-(2-(3-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)ethoxy)propanoic acid
Purity:	≥95% (HPLC)

VH 032 amide-alkylC3-amine

Catalog #: 7073

Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C3-NH₂
Chemical Name:	(2S,4R)-1-((S)-2-(4-Aminobutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

VH 032 amide-PEG5-acid

Catalog #: 7105

Product Documents

VHL ligand with PEG linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-PEG5-COOH
Chemical Name:	(S)-21-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-22,22-dimethyl-19-oxo-4,7,10,13,16-pentaoxa-20-azatricosanoic acid
Purity:	≥95% (HPLC)

VH 032 amide-PEG1-acid

Catalog #: 7104

Product Documents

VHL ligand with PEG linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-PEG1-COOH
Chemical Name:	3-(3-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propanoic acid
Purity:	≥95% (HPLC)

VH 032 amide-alkylC3-acid

Catalog #: 7216

Product Documents

VHL ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C3-COOH
Chemical Name:	5-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentanoic acid
Purity:	≥95% (HPLC)

VH 032 amide-PEG3-acid

Catalog #: 6679

Citations (1)

Product Documents

VHL ligand with PEG linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-PEG3-COOH
Chemical Name:	(S)-15-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-16,16-dimethyl-13-oxo-4,7,10-trioxa-14-azaheptadecanoic acid
Purity:	≥95% (HPLC)

VH 032 amide-alkylC7-amine

Catalog #: 7074

Citations (38)

Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C7-NH₂
Chemical Name:	(2S,4R)-1-((S)-2-(8-Aminooctanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
Purity:	≥95% (HPLC)

VH 032 amide-alkylC6-acid

Catalog #: 7107

Product Documents

VHL ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-C6-COOH
Chemical Name:	8-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-8-oxooctanoic acid
Purity:	≥95% (HPLC)

VH 032 amide-PEG4-acid

Catalog #: 7215

Product Documents

VHL ligand with PEG linker and terminal acid for onward chemistry

Alternate Names:	(S,R,S)-AHPC-PEG4-COOH
Chemical Name:	(S)-18-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-19,19-dimethyl-16-oxo-4,7,10,13-tetraoxa-17-azaicosanoic acid
Purity:	≥95% (HPLC)

VH 032 amide-alkylC6-amine

Catalog #: 6853

Product Documents

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	VH 032 - linker 8,(_S,R,S)-AHPC-C2-NH₂
Chemical Name:	(2S,4R)-1-((S)-2-(7-Aminoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

VH 032 amide-PEG3-amine

Catalog #: 6463

Citations (1)

Product Documents

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names:	(S,R,S)-AHPC-PEG3-NH₂
Chemical Name:	(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity:	≥95% (HPLC)

VHL: Small Molecules and Peptides

VH 032, amine

VH 032 amide-alkylC5-azide

VH 101, phenol

VH 032 amide-PEG3-BCN

VH 032 amide-alkylC9-amine

VH 101 phenol-alkylC4-amine

VH 032, propargyl

VH 032 amide-alkylC4-amine

VH 032 amide-PEG4-amine

VH 032 amide-alkylC2-acid

VH 101 phenol-alkylC6-amine

VH 032

VH 032 amide-PEG2-amine

VH 032 amide-alkylC5-amine

VH 032 amide-PEG2-acid

VH 032 amide-alkylC3-amine

VH 032 amide-PEG5-acid

VH 032 amide-PEG1-acid

VH 032 amide-alkylC3-acid

VH 032 amide-PEG3-acid

VH 032 amide-alkylC7-amine

VH 032 amide-alkylC6-acid

VH 032 amide-PEG4-acid

VH 032 amide-alkylC6-amine

VH 032 amide-PEG3-amine

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