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52 results for "VHL Small Molecules and Peptides" in Products

VHL: Small Molecules and Peptides

Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Functionalized VHL ligand for PROTACs

Chemical Name: (4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride
Purity: ≥98% (HPLC)
Functionalized VHL ligand for PROTACs

Amine functionalized VHL ligand for PROTAC® research

Chemical Name: (4R)-3-Methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-L-prolinamide dihydrochloride
Purity: ≥95% (HPLC)
Amine functionalized VHL ligand for PROTAC® research

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names: VH 032 - linker 8,(S,R,S)-AHPC-C2-NH2
Chemical Name: (2S,4R)-1-((S)-2-(7-Aminoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal amine for onward chemistry

VHL ligand with PEG linker and terminal acid for onward chemistry

Alternate Names: (S,R,S)-AHPC-PEG5-COOH
Chemical Name: (S)-21-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-22,22-dimethyl-19-oxo-4,7,10,13,16-pentaoxa-20-azatricosanoic acid
Purity: ≥95% (HPLC)
VHL ligand with PEG linker and terminal acid for onward chemistry

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-PEG6-NH2
Chemical Name: (2S,4R)-1-((S)-23-Amino-2-(tert-butyl)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with PEG linker and terminal amine for onward chemistry

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-C9-NH2
Chemical Name: (2S,4R)-1-((S)-2-(10-Aminodecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal amine for onward chemistry

VHL ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names: (S,R,S)-AHPC-C5-COOH
Chemical Name: 7-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptanoic acid
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal acid for onward chemistry

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-PEG2-NH2
Chemical Name: (2S,4R)-1-((S)-2-(2-(2-(2-Aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥95% (HPLC)
VHL ligand with PEG linker and terminal amine for onward chemistry

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-C7-NH2
Chemical Name: (2S,4R)-1-((S)-2-(8-Aminooctanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal amine for onward chemistry

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-C5-NH2
Chemical Name: (2S,4R)-1-((S)-2-(6-Aminohexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal amine for onward chemistry

VHL ligand with alkylC5 linker and terminal azide for onward chemistry

Chemical Name: (2S,4R)-1-((S)-2-(6-Azidohexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥95% (HPLC)
VHL ligand with alkylC5 linker and terminal azide for onward chemistry

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-PEG3-NH2
Chemical Name: (2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with PEG linker and terminal amine for onward chemistry

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-C10-NH2
Chemical Name: (2S,4R)-1-((S)-2-(11-Aminoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal amine for onward chemistry

Inhibitor of VHL; blocks interaction of VHL and HIF-α

Chemical Name: (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Inhibitor of VHL; blocks interaction of VHL and HIF-α

Hydroxyl functionalized VHL ligand

Chemical Name: (2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Hydroxyl functionalized VHL ligand

Functionalized VHL ligand for PROTAC® development

Chemical Name: (2S,4R)-1-((R)-2-Acetamido-3-mercapto-3-methylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥95% (HPLC)
Functionalized VHL ligand for PROTAC® development

Thiol functionalized VHL ligand

Chemical Name: (2S,4R)-1-[(2R)-2-[[(1-Fluorocyclopropyl)carbonyl]amino]-3-methyl-3-sulfanyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
Purity: ≥95% (HPLC)
Thiol functionalized VHL ligand

VHL ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name: (2S,4R)-N-(2-(4-Aminobutoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal amine for onward chemistry

VHL ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name: (2S,4R)-N-(2-((6-Aminohexyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal amine for onward chemistry

VHL ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names: (S,R,S)-AHPC-C2-COOH
Chemical Name: 4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal acid for onward chemistry

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-C3-NH2
Chemical Name: (2S,4R)-1-((S)-2-(4-Aminobutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal amine for onward chemistry

VHL ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names: (S,R,S)-AHPC-C3-COOH
Chemical Name: 5-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentanoic acid
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal acid for onward chemistry

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-phenol-C4-NH2
Chemical Name: (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-N-(2-(4-aminobutoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal amine for onward chemistry

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-phenol-C6-NH2
Chemical Name: (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-N-(2-((6-aminohexyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal amine for onward chemistry

Functionalized VHL building block for copper-free click chemistry

Chemical Name: ((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl ((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)carbamate
Purity: ≥90% (HPLC)
Functionalized VHL building block for copper-free click chemistry
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