VH 032 amide-alkylC7-amine
Tocris Bioscience, part of Bio-Techne | Catalog # 7074
VHL ligand with alkyl linker and terminal amine for onward chemistry
Key Product Details
Description
VHL ligand with alkyl linker and terminal amine for onward chemistry
Alternative Names
(S,R,S)-AHPC-C7-NH2
Product Description
VH 032 amide-alkylC7-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines
This product is provided for use in onward chemistry. Suitable solvents can be used. This product is sold as an xHCl salt. The stoichiometry of the salt and hydration levels vary from batch to batch. It is sold in gross weight with the batch specific Molecular Weight available on the Certificate of AnalysisProduct Specifications
Formula
C30H45N5O4S.xHCl
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
(2S,4R)-1-((S)-2-(8-Aminooctanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
InChI Key
RMNLYSBBFGSMFL-QVRKWNSCSA-N
SMILES
CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCCN)=O)=O)O)=O)SC=N1.Cl.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Calculators
Dilution Calculator
Reconstitution Calculator
Product Specific Notices for VH 032 amide-alkylC7-amine
For research use only
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