Me VH 032, amine
Tocris Bioscience, part of Bio-Techne | Catalog # 7634
Amine functionalized VHL ligand for PROTAC® research
Key Product Details
Description
Amine functionalized VHL ligand for PROTAC® research
Product Description
Me VH 032, amine is a derivative of the von Hippel-Lindau (VHL) ligand, VH 032 for use as a precursor to a PROTAC® that hijacks VHL as the E3 ubiquitin ligase component. Me VH 032, amine is supplied with a primary amine functional handle, for ready conjugation to a linker/target protein ligand. Introduction of the methyl group at the benzylic position of VH 032 is associated with improved binding affinity.Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
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Usage Guidelines
This product is provided for use in onward chemistry. Suitable solvents can be used.Product Specifications
Molecular Weight
517.51
Formula
C23H32N4O3S.2HCl
Storage
Desiccate at RT
Purity
≥95% (HPLC)
Chemical Name
(4R)-3-Methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-L-prolinamide dihydrochloride
CAS Number
2504950-56-3
PubChem ID
137319712
InChI Key
YTJDUDNKHHNDRD-ARZBPYMHSA-N
SMILES
CC1=C(C2=CC=C(C=C2)[C@H](C)NC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)N)=O)O)=O)SC=N1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hu Discovery of ERD-308 as a highly potent proteolysis targeting chimera (PROTAC) degrader of estrogen receptor (ER). J.Med.Chem. 2019 PMID: 30990042
Product Specific Notices for Me VH 032, amine
For research use only
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