TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
687 results for "TIM-3" in Products
687 results for "TIM-3" in Products
TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #TIM3/3113 |
| Applications: | IHC, ELISA, MA |
![Immunohistochemistry-Paraffin: TIM-3 Antibody (TIM3/3113) - Azide and BSA Free [NBP2-79836]](https://resources.bio-techne.com/images/products/TIM-3-Antibody-TIM3-3113-Azide-and-BSA-Free-Immunohistochemistry-Paraffin-NBP2-79836-img0003.jpg "Immunohistochemistry-Paraffin: TIM-3 Antibody (TIM3/3113) - Azide and BSA Free [NBP2-79836]")
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #TIM3/3113 |
| Applications: | IHC, ELISA, MA |
![Immunohistochemistry-Paraffin: TIM-3 Antibody (TIM3/3113) [NBP2-79702]](https://resources.bio-techne.com/images/products/TIM-3-Antibody-TIM3-3113-Immunohistochemistry-Paraffin-NBP2-79702-img0003.jpg "Immunohistochemistry-Paraffin: TIM-3 Antibody (TIM3/3113) [NBP2-79702]")
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #TIM3/6863R |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #TIM3/6863R |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #TIM3/6863R |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #TIM3/6863R |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #TIM3/3113 |
| Applications: | IHC, ELISA, MA |
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #TIM3/3113 |
| Applications: | IHC, ELISA, MA |
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #TIM3/3113 |
| Applications: | IHC, ELISA, MA |
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #TIM3/6863R |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #TIM3/3113 |
| Applications: | IHC, ELISA, MA |
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #TIM3/6863R |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #TIM3/6863R |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #TIM3/6863R |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #TIM3/3113 |
| Applications: | IHC, ELISA, MA |
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #TIM3/6863R |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #TIM3/3113 |
| Applications: | IHC, ELISA, MA |
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #TIM3/3113 |
| Applications: | IHC, ELISA, MA |
| Reactivity: | Human |
| Details: | Rabbit IgG Kappa Monoclonal Clone #TIM3/6863R |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #TIM3/3113 |
| Applications: | IHC, ELISA, MA |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, CyTOF-ready, Dual ISH-IHC, +1 More |
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #344823 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2321C |
| Applications: | WB, Flow, IHC, CyTOF-ready |
| Sensitivity: | 8.75 pg/mL |
| Applications: | ELISA |
| Assay Range: | 31.3 - 2,000 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma, Urine) |
