14 results for "ROCK2 Small Molecules and Peptides" in Products
ROCK2 Small Molecules and Peptides
ROCK2/II (Rho-associated protein kinase 2; also Rho-kinase alpha) is a member of the AGC serine/threonine protein kinase family. ROCK2 is a downstream target of activated RhoA. Its activation results in myosin phosphorylation with subsequent muscle contraction. Human ROCK2 is 1388 amino acids (aa) in length, and appears to be present as a dimer. It contains a protein kinase domain (aa 92-354), a coiled-coil region (aa 429-1131) and a zinc-finger region (aa 1260-1315). Two isoforms show an alternate start site at M686, and a three aa substitution for the N-terminal 444 amino acids. Over aa 641-846, human ROCK2 shares 94% and 96% aa identity with mouse and canine ROCK2, respectively.
Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component
Y-27632 synthesized to cGMP guidelines
Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis
Selective Rho-kinase (ROCK) inhibitor
Inhibitor of cyclic nucleotide dependent- and Rho-kinases
Potent and selective ROCK inhibitor
Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)
Potent Rho-kinase inhibitor; vasodilator
Potent and highly selective ROCK inhibitor; orally active
Potent and highly selective ROCK inhibitor; orally active
Potent and highly selective ROCK inhibitor; orally active
Potent and selective LIMK inhibitor; antitumor
Sterile-filtered 10 mM solution of Y-27632, selective ROCK inhibitor, pre-dissolved in water
Potent and highly selective ROCK inhibitor; orally active